346 results match your criteria: "Marchiafava-Bignami Disease"
Neurol India
January 2020
Department of Radiology and Imaging, Holy Family Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
Neurocase
August 2018
d Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center, Gainesville , FL , USA.
With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial damage can also exhibit spatial neglect. The goal of this report is to learn the role of the splenium of the corpus callosum in mediating visuospatial attention.
View Article and Find Full Text PDFNeurol Sci
February 2019
Department of Neurology, The Affiliated Hospital of Jiujiang University, No.57 Xunyang East Rode, Xunyang District, Jiujiang, 332000, Jiangxi Province, People's Republic of China.
Case Rep Neurol
August 2018
Department of Rehabilitation Medicine, Fukui General Hospital, Fukui City, Japan.
We report a 68-year-old right-handed female who was admitted to our hospital complaining chiefly of incontinence and decreased activity. Her brain images showed characteristics of Marchiafava-Bignami disease, such as symmetrical abnormal signals localized in the corpus callosum. The patient had no drinking habits.
View Article and Find Full Text PDFIndian J Psychol Med
January 2018
Department of Psychiatry, Jamaica Hospital Center, Jamaica, New York, USA.
J Investig Med High Impact Case Rep
June 2018
Augusta University, Augusta, GA, USA.
We describe a rare case of nonalcoholic Marchiafava-Bignami disease (MBD) in the setting of malnourishment after gastric bypass. A 44-year-old nonalcoholic Caucasian woman with malnutrition after gastric bypass presented with 2 weeks of weakness. The patient acutely became stuporous.
View Article and Find Full Text PDFActa Neurol Belg
June 2019
Department of Neurology, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.
Background: Marchiafava-Bignami disease (MBD) is a neurological degenerative disorder with a pathognomonic hallmark of symmetric demyelination in the corpus callosum (CC). Most reported cases were chronic alcoholics and some showed cortical lesions related to poor clinical prognosis. Herein we report a case of a chronic alcoholic who presented with confusion and generalized weakness.
View Article and Find Full Text PDFQJM
October 2018
Department of Neurology, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki-city, Okayama, Japan.
Neurocase
February 2018
c Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center, Gainesville , FL , USA.
Apraxic agraphia can be caused by left hemispheric cerebral lesions in the area that contains the spatial representations of the movements required to write, from a lesion in, or connections to, the frontal premotor cortex that converts these spatial representations to motor programs (Exner's area). A right-handed woman with Marchiafava Bignami disease and lesions of the genu and splenium of her corpus callosum had apraxic agraphia without ideomotor apraxia of her left. A disconnection of Exner's area in the left hemisphere from the right hemisphere's premotor and motor areas may have led to her inability to write with her left hand.
View Article and Find Full Text PDFMedicine (Baltimore)
February 2018
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Pediatrics, E-Da Dachang Hospital Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Program in Translational Medicine, Kaohsiung Medical University and Academia Sinica Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Rationale: Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation.
View Article and Find Full Text PDFMedicine (Baltimore)
February 2018
Department of Neurology, Shengjing Hospital of China Medical University, Heping District, Shenyang, Liaoning, People's Republic of China.
Marchiafava-Bignami disease (MBD) is a rare neurological disease usually associated with chronic alcoholism and characterized by demyelination and necrosis. Our aims were to describe the clinicoradiological features and identify factors that may affect the prognosis of patients with MBD.We examined clinical manifestations, laboratory results, and neuroradiological features of 9 patients with MBD.
View Article and Find Full Text PDFMarchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors.
View Article and Find Full Text PDFNeurol India
June 2019
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Med Hypotheses
July 2017
Helios-Klinikum Pirna, Struppener Straβe 13, D-01796 Pirna, Saxony, Germany. Electronic address:
Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue edema can be the cause of demyelinating lesions. Even though brain edema occurs in the whole brain, the authors assume that the characteristically focal appearance of demyelinated lesions, for instance of multiple sclerosis plaques, are attributable to anatomical and structural characteristics of the brain.
View Article and Find Full Text PDFAnn Neurosci
May 2017
Interna de Medicina, Universidad de los Andes de Chile, Santiago, Chile.
The Marchiafava-Bignami disease, characterized by demyelination and necrosis of the corpus callosum, has typically been associated with chronic alcohol intake, and clinically has various symptoms and signs. However, several cases have been reported without alcohol association, and these - according to several publications - have some common points, such as preference for female, related to malnutrition, and radiological involvement of the splenium of the corpus callosum. We report a case of a patient with the characteristics described above and whose clinical manifestation was Athetosis.
View Article and Find Full Text PDFNeurol India
July 2019
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
J Assoc Physicians India
March 2017
Professor & Unit Head, Department of Medicine, RNT Medical College, Udaipur, Rajasthan.
Marchiafava-Bignami Disease (MBD) is a progressive neurological disease, characterized by corpus callosal demyelination and necrosis and subsequent atrophy. It is usually seen in the context of alcoholism and malnutrition. Clinical diagnosis of this disease is quite challenging due to various presentations but a high degree of suspicion often leads to the correct diagnosis with help of neuroimaging.
View Article and Find Full Text PDFNeurology
April 2017
From the Departments of Neurology (Z.S., N.A., B.R., M.H.) and Pathology (L.S.), Rutgers New Jersey Medical School, Newark, NJ.
Eur J Clin Nutr
May 2017
Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on.
View Article and Find Full Text PDFJ Med Imaging Radiat Oncol
August 2017
Neuroradiology and Neurointerventional Service, Department of Radiology, Beaumont Hospital, Beaumont, Ireland.
Alcohol is one of the most commonly abused substances worldwide. It results in a wide range of diseases and disorders affecting many organ systems. Alcohol-related nutritional deficiencies and electrolyte disturbance leave chronic abusers at risk of a range of demyelinating conditions to which the radiologist and clinician should always be alert.
View Article and Find Full Text PDFBMJ Case Rep
November 2016
James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK.
A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement.
View Article and Find Full Text PDFJ Assoc Physicians India
November 2016
Professor, Dept. of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.
Marchiafava Bignami disease (MBD) is a rare and devastating complication of chronic alcoholism. Degeneration of the corpus callosum is the hallmark feature of MBD. Early diagnosis of MBD by its typical "Sandwich Sign" on magnetic resonance imaging (MRI).
View Article and Find Full Text PDFRadiologia
April 2018
Área Clínica de Imagen Médica, Hospital Universitario y Politécnico La Fe, Valencia, España.
Recreational drug abuse represents a serious public health problem. Neuroimaging traditionally played a secondary role in this scenario, where it was limited to detecting acute vascular events. However, thanks to advances in knowledge about disease and in morphological and functional imaging techniques, radiologists have now become very important in the diagnosis of acute and chronic neurological complications of recreational drug abuse.
View Article and Find Full Text PDFCase Rep Neurol Med
September 2016
Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives. The aim of this article is to represent the first reported case with cooccurrence of two rare alcohol related complications. Case Report.
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