346 results match your criteria: "Marchiafava-Bignami Disease"

Marchiafava-Bignami disease (MBD) is a rare neurological disorder predominantly associated with chronic alcohol use, characterized by demyelination and necrosis of the corpus callosum. The condition often presents with cognitive dysfunction, motor deficits, and altered consciousness, which can range from mild confusion to severe stupor. Early recognition and treatment are crucial for improving outcomes.

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Marchiafava-Bignami disease (MBD) is a neuropathological condition characterized by demyelination and necrosis of the corpus callosum. This condition is commonly found in malnourished and alcoholic patients, but it is rarely observed in non-alcoholic individuals. In this case report, we describe a non-alcoholic patient who underwent two consecutive gastrointestinal surgeries.

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Marchiafava-Bignami disease is a rare neurological condition characterized by necrosis and demyelination of the corpus callosum, typically associated with chronic alcoholism and/or malnutrition. The clinical manifestations of Marchiafava-Bignami disease are diverse and often nonspecific. Diagnosis of Marchiafava-Bignami disease relies on magnetic resonance imaging findings, which reveal significant and symmetrical involvement of the corpus callosum.

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Relationship between alcohol consumption and cognitive impairment in the adult population over 60 years of age: A systematic review.

Rev Colomb Psiquiatr (Engl Ed)

November 2024

Instituto de Neuropsiquiatría y Adicciones (INAD), Centros Asistenciales Dr. Emili Mira i López (CAEMIL-Recinto Torribera), Parc de Salut Mar, Santa Coloma de Gramenet, Barcelona, Spain.

Article Synopsis
  • Alcohol consumption is linked to cognitive impairment in individuals aged 60 and older, with both excessive and moderate drinking influencing cognitive health.
  • A systematic review of studies from 2010 to 2020 identified that excessive and prolonged alcohol use can lead to serious forms of dementia and cognitive impairment, citing notable disorders like Wernicke-Korsakoff syndrome.
  • The cognitive functions most impacted by alcohol use disorder include executive functions, visuospatial skills, attention, and memory, emphasizing the risks associated with high levels of alcohol intake.
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Clinical analysis of Marchiafava-Bignami disease.

BMC Neurol

October 2024

Department of Neurology, Hebei Hospital of Xuanwu Hospital Capital Medical University, Shijiazhuang, Hebei, 050031, People's Republic of China.

Background: Marchiafava-Bignami disease (MBD) is an exceptionally rare condition, a fact that should pique the professional curiosity of medical practitioners. In recent years, case reports of this disease have been infrequent, and no comprehensive analysis or summary of the characteristics of the published cases has been conducted.

Methods: We collected the medical records of three patients treated at our hospital from March 2022 to March 2023.

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Marchiafava Bignami Disease (MBD) is a reversible neurological disorder with can be difficult to diagnose initially due to variable neurological presentations that can be seen in patients. Physicians need to consider this diagnosis as the readily available treatment of thiamine can help reverse symptoms and prevent long lasting effects. We present the case of a 52-year-old man with a history of alcohol use disorder who presented with concerns for a cerebrovascular accident.

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Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurological signs and symptoms, ranging from moderate dysarthria or mild disorientation to coma and death. We report a case of a 30-year-old, 14-week pregnant female who presented with complaints of persistent vomiting and loss of appetite.

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Marchiafava-Bignami disease (MBD) is a rare demyelinating disease associated with chronic alcohol use and/or malnutrition leading to vitamin deficiency. Clinical presentation is diverse and can range from mild neurological deficits of dysarthria and confusion to severe symptoms such as coma or even death. Diagnosis is made using imaging modalities including magnetic resonance imaging (MRI) and computed tomography (CT) with the rise in technological advances placing MRI as the most sensitive and specific imaging technology for diagnosis.

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Background: Marchiafava-Bignami disease is a rare neurological disease characterized by acquired lesions of the corpus callosum. Although the major causative etiology is chronic alcoholism, a case caused by acute alcohol intoxication has not yet been reported.

Case Presentation: A 19-year-old female with no known medical history or a history of chronic alcohol consumption was brought to the emergency department in a coma after binge alcohol consumption.

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Purpose: To detect the Marchiafava Bignami Disease (MBD) using a distinct deep learning technique.

Background: Advanced deep learning methods are becoming more crucial in contemporary medical diagnostics, particularly for detecting intricate and uncommon neurological illnesses such as MBD. This rare neurodegenerative disorder, sometimes associated with persistent alcoholism, is characterized by the loss of myelin or tissue death in the corpus callosum.

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Key Clinical Message: Marchiafava-Bignami disease, a rare condition often associated with alcoholism, shows myelin degeneration with tissue necrosis specifically in the corpus callosum. Urgent application of magnetic resonance imaging could lead to prompt diagnosis.

Abstract: A 66-year-old male with habitual alcohol drink complained acute deterioration of left-side muscle weakness as initial presentation.

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Among the various manifestations of COVID-19, the neurological implications of SARS-CoV-2 infection are of significant concern. Marchiafava-Bignami disease (MBD), a neurodegenerative disorder, exhibits a clinical spectrum ranging from mild progressive dementia in its chronic form to states of acute coma and varied mortality rates. Acute MBD primarily occurs in chronic alcoholics and malnourished individuals and is characterized by sudden loss of consciousness, seizures, confusion, and psychosis.

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Article Synopsis
  • Marchiafava-Bignami disease is a rare condition causing damage in the central nervous system, specifically leading to demyelination and necrosis.
  • A 60-year-old Japanese man with this disease experienced oromandibular dystonia after taking a low dose of olanzapine, but his symptoms resolved when the medication was stopped.
  • The case highlights how demyelinating lesions in the corpus callosum may play a role in dystonia, suggesting a more complex interaction between brain structures than previously understood.
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Marchiafava-Bignami disease: why not Marchiafava-Bignami-Carducci disease?

Neurol Sci

May 2024

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

The Marchiafava-Bignami disease has a curious backstory, namely, the publication in 1898 of the Contribution to the Study of Nonsuppurative Encephalitis (Carducci A in Riv Psicol Psichiat Neuropat 8-9:125-135, 1898), in which the neo-graduate Agostino Carducci described the disease that the pathologists Ettore Marchiafava and Amico Bignami would report 5 years later.

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Hand knob sign in Marchiafava-Bignami disease and Wernicke's encephalopathy.

Neurol Sci

June 2024

Department of Neurology, Chiba Rosai Hospital, 2-16 Tatsumidai-Higashi, Ichihara-shi, Chiba, 290-0003, Japan.

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Clinico-radiologic subtypes and therapeutic observation of acute Marchiafava-Bignami disease.

Sci Rep

October 2023

Department of Medical Imaging, Affiliated Hospital of Yangzhou University, No. 368, Hanjiang Middle Road, Hanjiang District, Yangzhou, 225100, China.

We aimed to investigate the clinico-radiologic features of acute Marchiafava-Bignami disease (MBD) and its evolutionary process after effective treatment through subgroup comparison. The clinical and MRI data of 23 patients with acute MBD were retrospectively analyzed and divided into type A (12 cases, with entire callosal involvement) and type B (11 cases, with focal callosal involvement). The clinical assessments and MRI findings (before and after treatment) were compared between the two subtypes.

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Marchiafava-Bignami disease (MBD) is a very rare disorder characterized by demyelination and necrosis of the corpus callosum. A 53-year-old male was transported to the emergency room with impaired consciousness. On his arrival, he was quite emaciated.

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Marchiafava-Bignami disease (MBD) is a metabolic disease of the nervous system. It mainly involves the Corpus callosum, but the handknob area is rarely involved. This article reports a MBD case involving the bilateral handknob area.

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Marchiafava-Bignami disease: Case presentation and radiological imaging.

Radiol Case Rep

November 2023

Advanced Radiology Services, P.C.3264 North Evergreen Drive NE, Grand Rapids, MI 49525 United States.

Marchiafava-Bignami disease (MBD) is a rare vitamin B deficiency classically associated with alcoholism. MBD damages the corpus callosum and presents with nonspecific neurological symptoms. Radiological imaging is critical for diagnosing MBD and commencing subsequent treatment, which often consists of vitamin B supplementation.

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Objective: Most patients with Marchiafava-Bignami disease (MBD) had unfavorable prognosis, with disability or death. We aimed to determine the risk factors of early unfavorable prognosis of MBD, and to develop a predictive nomogram for early unfavorable prognosis of MBD.

Methods: MBD patients admitted to our hospital between 1 January 2013 and 31 December 2021 were included.

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Analysis of 21 Patients With Alcoholic Marchiafava-Bignami Disease in Chongqing, China.

Can J Neurol Sci

July 2024

Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Objective: This study aimed to investigate the characteristics and prognosis of patients with alcoholic Marchiafava-Bignami disease (MBD), a rare neurological disorder commonly associated with chronic alcoholism, in Chongqing, China.

Methods: We conducted a retrospective analysis of clinical data from 21 alcoholic MBD patients treated at the First Affiliated Hospital of Chongqing University between 2012 and 2022.

Results: The study included 21 patients with alcoholic MBD who had a mean age of 59 ± 9.

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Marchiafava Bignami disease (MBD) is a neurological disorder characterized by myelin degeneration and tissue necrosis within the central nervous system. This condition predominantly afflicts individuals with chronic alcohol abuse and malnutrition. The most distinctive pathological feature of MBD is the necrotic degeneration specifically observed in the corpus callosum; however, emerging evidence also indicates the potential involvement of other brain regions.

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