Detection and comparison of microsatellite marker D9S1747 with clinical stages and grades of oral squamous cell carcinoma.

Background: One of the main characteristics of oral squamous cell carcinoma (OSCC) is genetic alteration in specific target regions. Allelic imbalance in tumor suppressor genes is the key event in OSCC which is associated with loss of heterozygosity mostly on chromosome 9p21 locus which includes p16 marker. p16 (D9S1747) is a microsatellite marker which detects early changes in OSCC.

Forensic application of frontal sinus measurement among the Indian population.

Aim: Studies have been done in diversified population, demonstrating the uniqueness of frontal sinus; data related to the Indian population are less. Thus, the present study was aimed to determine the frontal sinus measurement and to assess its forensic application in the Indian population.

Materials And Methods: A total of 400 individuals with Indian origin (21-30 years) were included in the study.

Pulpotomy with curcumin: Histological comparison with mineral trioxide aggregate in rats.

Context: It is important to develop new therapeutic materials that have requisite clinical actions, are safe and economical.

Aims: This study aims to histologically evaluate curcumin, an extract of turmeric (Curcuma longa) as a pulpotomy agent in rat molars and to compare it to mineral trioxide aggregate (MTA).

Settings And Design: Animal study.

Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease.

Periodontal disease is an oral inflammatory disease that destroys the tooth supporting periodontal tissues resulting in tooth loss. Porphyromonas gingivalis is a keystone pathogen that plays a significant role in periodontitis. In previous studies, resveratrol has shown significant results by targeting inflammatory and adhesive markers.

In vitro evaluation of antimicrobial property of silver nanoparticles and chlorhexidine against five different oral pathogenic bacteria.

Introduction: Numerous antimicrobial agents are used to eliminate oral biofilm. However due to emergence of multi drug resistant microorganisms, the quest to find out biologically safe and naturally available antimicrobial agents continues.

Aim: To evaluate antimicrobial efficacy of silver nano-particles against five common oral pathogenic bacteria.

Interleukin-21 and its association with chronic periodontitis.

Context: Interleukin-21 (IL-21) is a pleiotropic cytokine, well documented to contribute to the development of Th17 cells which have been shown to play an important role in the pathogenesis of periodontitis. Periodontal disease is a chronic infection of tooth-supporting tissue.

Aim: This study evaluates the saliva and serum levels of IL-21 in patients with chronic periodontitis and periodontally healthy individuals.

Detection of human papilloma virus-E6/E7 proteins of high-risk human papilloma virus in saliva and lesional tissue of oral squamous cell carcinoma patients using nested multiplex polymerase chain reaction: A comparative study.

Introduction: Human papilloma virus (HPV)-associated oral squamous cell carcinoma (OSCC) shows different biological behavior as compared to tobacco-induced OSCC. Mere presence of HPV in OSCC is of no clinical significance; however, the integration of HPV-DNA through E6/E7 gene into the host genome is important as it affects the development and progression of OSCC.

Aim: The aim of this study was to determine the presence of E6/E7 proteins of high-risk (HR) HPV (HPV16 and HPV18) in saliva as well as lesional tissue of OSCC patients and to determine the use of saliva as an alternative to tissue for E6 and E7 proteins in OSCC.

Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: evaluation.

Melanoma is the most deadly and life-threatening form of skin cancer with progressively higher rates of incidence worldwide. The objective of the present investigation is to develop and to statistically optimize and characterize curcumin (CUR) loaded ethosomes for treatment of melanoma. A two factor, three level (3) factorial design approach was employed for the optimization of ethosomes.

Efficacy of Caries Removal by Carie-Care and Erbium-doped Yttrium Aluminum Garnet Laser in Primary Molars: A Scanning Electron Microscope Study.

Aim: To compare and evaluate morphological changes and bacterial deposits in primary carious molars after caries excavation with Carie-Care, erbium-doped yttrium aluminum garnet (Er:YAG) laser, and round tungsten carbide bur.

Materials And Methods: Thirty human carious primary molars extracted for therapeutic reasons were sectioned mesiodistally. These sectioned samples were allocated into three groups (20 samples each): group I: Carie Care, group II: Er:YAG laser, and group III: round tungsten carbide bur.

Detection of antibodies against Aggregatibacter actinomycetemcomitans in serum and saliva through ELISA in periodontally healthy individuals and individuals with chronic periodontitis.

Background: Periodontitis is a persistent polymicrobial infection, which leads to chronic inflammation in the tooth supporting tissues. Aggregatibacter actinomycetemcomitans are normal commensals of oral cavity but are low in number in periodontally healthy subjects. They are one of the major pathogens aetiologically linked to periodontal disease.

Comparison of Frontozygomatic versus Sigmoid Notch Approach for Extraoral Maxillary Nerve Block Anesthesia: A Prospective Clinical Trial.

Background: With definitive indications, extraoral techniques of achieving regional nerve blocks are a boon to oral and maxillofacial surgical practice. Though less commonly practiced, since general anesthesia is more favored, certain medical conditions favor the use of regional nerve blocks over general anesthesia. To block the maxillary nerve extraorally, sigmoid notch approach and frontozygomatic approach have been previously described in the literature, but a clinical trial comparing these techniques is sparse.

Serotypes of in relation to periodontal status and assessment of leukotoxin in periodontal disease: A clinico-microbiological study.

Context: (A.a) serotypes may add some important information of the pathogenetic background of periodontal infections. A.

Identification of multiple strains of using heteroduplex polymerase chain reaction in varying severity of chronic periodontitis.

Aim: Research has demonstrated that there are multiple strains of Porphyromonas gingivalis with varying potency to cause periodontal disease. The current study aims at using heteroduplex polymerase chain reaction (PCR) to detect the strain diversity of P. gingivalis in periodontitis lesions of varying severity in a sample of the Indian population.

Antimicrobial Efficacy of Octenidine Hydrochloride and Calcium Hydroxide with and Without a Carrier: A Broth Dilution Analysis.

Background: An efficient antimicrobial agent action is required for a predetermined time period for absolute elimination of root canal microbes. Till date, there is limited or no data on the antimicrobial effect of octenidine as an intracanal medicament with chitosan (CTS) as a carrier against and .

Aim: The aim of this microbiological study was to compare the antimicrobial efficacy of octenidine hydrochloride (OHC) and calcium hydroxide (Ca[OH]) as intracanal medicaments, both independently and along with CTS as a carrier molecule against the common resistant endodontic pathogens.

Evaluation of peripheral neutrophil functions in aggressive periodontitis patients and their family members in Indian population: An assessment of neutrophil chemotaxis, phagocytosis, and microbicidal activity.

Background: Association of neutrophil function abnormalities with localized aggressive periodontitis (LAP) has been reported in Indian population. There are no published studies on the familial aggregation of aggressive periodontitis (AP) and neutrophil function abnormalities associated with it in Indian population. The present study aimed to assess neutrophil chemotaxis, phagocytosis, and microbicidal activity in AP patients and their family members of Indian origin, who may or may not be suffering from AP.

Profiling of Serotypes B and C and the genotypes in periodontal health and disease.

Background: A. actinomycetemcomitans is prevalent in periodontitis but is found in some periodontally healthy individuals as well. Certain serotypes of the organism have shown to determine severity of the disease.

Synthesis, crystal structure and biological properties of a cis-dichloridobis(diimine)copper(II) complex.

The mechanisms of interaction of inorganic complexes with DNA are important in the design and development of new metal-based drug molecules. The limitations of cis-platin have encouraged the design and development of new metal-based target-specific anticancer drugs having reduced side effects. The complex cis-dichloridobis(1,2,5-thiadiazolo[3,4-f][1,10]phenanthroline-κN,N)copper(II), [CuCl(CHNS)], has been synthesized and characterized.

Antimicrobial activity of root canal irrigants against biofilm forming pathogens- An study.

Aims: The aim of the study was to check the antimicrobial activity of the 5% Sodium hypochlorite, 2% Chlorhexidine, 0.10% Octenidine (OCT), and 2% Silver Zeolite (SZ) at different time intervals against a single species biofilm of , , and model prepared on a nitrocellulose membrane.

Settings And Design: nitrocellulose biofilm model was used to check antibacterial efficacy of root canal irrigants.

Design and Synthesis of Some Novel Fluorobenzimidazoles Substituted with Structural Motifs Present in Physiologically Active Natural Products for Antitubercular Activity.

Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, H-NMR, C-NMR, Mass, and elemental analysis.

Effect of Mixed with Tissue Conditioners in Varying Doses on Colonization and Inhibition of : An Study.

Aims And Objectives: The study was conducted to evaluate the Colonization & Inhibition of Candida albicans in selected commercially available denture lining materials material by mixing them with varying concentrations and doses of tea tree oil.

Materials And Methods: Five test discs of 10mm diameter and 1.5mm thickness were prepared using commercially available soft denture lining materials (Viscogel and GC-soft).

Synthesis, structural characterization and biological properties of phosphorescent iridium(III) complexes.

Two phosphorescent cyclometalated iridium(III)-triptycenyl-1,10-phenanthroline complexes [Ir(ppy)(tpt-phen)] (1) and [Ir(bhq)(tpt-phen)] (2) {ppy=2-phenylpyridine, bhq=Benzo[h]quinoline, tpt-phen=triptycenyl-1,10-phenanthroline} have been synthesized and structurally characterized. The structure of complex 2 has been studied by single crystal X-ray crystallography. The photophysical properties of complexes in a different solvent have also been investigated.

Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial.

Aims And Objective: The aim of this study was to evaluate and compare the effect of chlorhexidine (CHX) chip and turmeric chip as a local drug delivery (LDD) agent in the treatment of patients with chronic periodontitis.

Materials And Methods: A total of 120 sites with pocket depths 5-8 mm were chosen as a split mouth design at 3 sites in the same patient. Selected sites were randomly divided into three groups to receive CHX chip in addition to scaling and root planing (SRP) in group A, turmeric chip in addition to SRP in group B, and SRP only in group C.

Evaluation of Surface Microhardness Following Chemical and Microwave Disinfection of Commercially Available Acrylic Resin Denture Teeth.

Introduction: Denture disinfection is an indispensable procedure for preventing cross contamination and the maintenance of a healthy oral mucosa in patients rehabilitated with removable dental prosthesis. Nevertheless, they are known to cause changes in the physical and mechanical properties of denture base resins and acrylic resin denture teeth following immersion of a denture in a suitable chemical disinfectant solution or by undergoing microwave irradiation. One such mechanical property indicator for artificial tooth materials is hardness.

A comprehensive study of worldwide selfie-related accidental mortality: a growing problem of the modern society.

Since Oxford dictionary has described 'Selfie', selfie deaths have received a fair amount of coverage but the extent of the problem and the data behind it have not been appropriately explored. The aim of our study is to obtain epidemiological characteristics of selfie-related mortality worldwide with the objective of providing an insight to 'Why selfie', 'Why risky', 'Psychological basis' and 'measures of control.' Despite thousands of web pages, very few scientific articles are available in medical journals.