397 results match your criteria: "Maranon University Hospital[Affiliation]"

Article Synopsis
  • - Multi-criteria decision analysis (MCDA) was used to improve clinical decisions for biological therapies in psoriasis, highlighting bimekizumab's effectiveness over various treatment options.
  • - The EVIDEM framework helped assess the therapies, with expert opinions translating into a model that evaluated the drug's benefits and consistency in scoring.
  • - Bimekizumab demonstrated significant therapeutic advantages, offering better patient outcomes while maintaining safety, making it a strong choice for moderate-to-severe psoriasis compared to other treatments.
View Article and Find Full Text PDF

In this manuscript, we briefly report on the Spanish health care system and the current situation of Thoracic Surgery in the country. Our surgical speciality is approached in terms of national spread of thoracic units, education, technological development, and other relevant aspects. Thoracic Surgery national workforce is also reviewed and compared to sister specialities.

View Article and Find Full Text PDF

Background: The WHO ordinal severity scale has been used to predict mortality and guide trials in COVID-19. However, it has its limitations.

Objective: The present study aims to compare three classificatory and predictive models: the WHO ordinal severity scale, the model based on inflammation grades, and the hybrid model.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to understand how inflammation affects the response to ocrelizumab treatment in patients with primary-progressive multiple sclerosis (PPMS).
  • Researchers followed 69 patients, looking at those with and without gadolinium-enhancing lesions on MRI, finding that over 60% achieved "no evidence of disease activity" (NEDA) after one year.
  • The results suggested that in patients with Gd+ lesions, a low rate of inflammatory B cells and decreased serum neurofilament levels were significant, while in Gd- patients, NEDA was associated with changes in other immune cells and increased serum IgA levels.
View Article and Find Full Text PDF

Objective: To study the impact of neoadjuvant therapies on postoperative complications and mortality among non-small-cell lung cancer (NSCLC) patients subjected to anatomic lung resection and included in the Spanish cohort of the video-assisted thoracic surgery (GE-VATS) multicenter database.

Methods: The study included a total of 3085 patients from 33 centers between December 2016 and March 2018. We performed a comparative analysis of the complications and mortality in patients who received neoadjuvant therapies (n = 263) versus those who did not (n = 2822).

View Article and Find Full Text PDF

Objective: Lung ultrasound is a useful tool for diagnosis and follow-up of diseases in critically ill neonates. Its use is increasingly widespread thanks to its advantages over other imaging tests and the rapidly growing body of evidence to support it, and "point-of-care ultrasound" (POCUS) has become a key component in neonatal guidelines. The objective of this special article is to present the foundations and the established diagnostic and therapeutic applications of lung ultrasonography as well as introducing new applications.

View Article and Find Full Text PDF

Background: This study aimed to assess observer variability and describe renal resistive index (RRI) and pulsatility index (PI) before and after onset of continuous kidney replacement therapy (CKRT). A secondary objective was to correlate Doppler ultrasound findings with those from direct measurement of renal blood flow (RBF).

Methods: This is a prospective observational study in hemodynamically stable Maryland piglets with and without acute kidney injury (AKI) and in hemodynamically unstable critically ill children requiring CKRT.

View Article and Find Full Text PDF

Evidence suggests that pregnant women are at a higher risk of complications compared to the general population when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the reasons that lead them to need intensive care are not clear. This is a prospective multicenter study of SARS-CoV-2 positive pregnant women, registered by the Spanish Obstetric Emergency Group, with the objective to define the characteristics of the mothers who were admitted to the Intensive Care Unit (ICU) and to investigate the causes and risk factors for ICU admission. A total of 1347 infected pregnant women were registered and analyzed, of whom, 35 (2.

View Article and Find Full Text PDF

Background: Oncological outcomes of self-expanding metallic stent used as a bridge to surgery in potential curative patients with left-sided colonic cancer obstruction remain unclear. The aim of this study was to investigate perioperative and mid-term oncological outcomes of 2 of the currently most commonly performed treatments in left-sided colonic cancer obstruction.

Methods: This is a retrospective multicenter study including patients with left-sided colonic cancer obstruction treated with curative intent between 2013 and 2017.

View Article and Find Full Text PDF

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic autoinflammatory bone disease characterised by noninfective inflammation of bones. Diagnostic approach is challenging and requires exclusion of other causes such as malignancies or infections. Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are usually applied as first-line therapy in CRMO patients; however, some cases require more intensive therapy with second-line agents to control disease activity.

View Article and Find Full Text PDF

Background: Antimicrobial defined daily dose (DDD), a standardized metric to assess antimicrobial consumption in adult population, has limitations hampering its use in neonatal patients. This study proposes an alternative DDD design applicable for neonates.

Methods: Neonates (<1 month-old) from 6 Spanish hospitals during a 12-months period were included.

View Article and Find Full Text PDF

Unlabelled: To establish the ability of somatosensory-evoked potentials (SEPs) to detect neurological damage in neonatal patients with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). Retrospective study including 84 neonates ≥ 36 weeks of gestational age with HIE and TH with SEPs performed in the first 14 days of life. SEPs from the median nerve were performed after completion of TH.

View Article and Find Full Text PDF

Recent evidence confirms the risks of discontinuity of care when young people make a transition from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS), although robust data are still sparse. We aimed to identify when and how patients get lost to care during transition by tracking care pathways and identifying factors which influence dropping out of care during transition. This is a retrospective observational study of 760 patients who reached the transition age boundary within 12 months before transition time and being treated at CAMHS for at least during preceding 18 months.

View Article and Find Full Text PDF
Article Synopsis
  • This document is a collaborative effort by three Spanish medical organizations focused on addressing sternal wound infections following surgery.
  • A diverse group of specialists, including surgeons, microbiologists, and internal medicine doctors, has come together to formulate this consensus.
  • The aim is to create evidence-based guidelines for preventing, diagnosing, and managing post-surgical mediastinitis, ultimately improving patient care and outcomes.
View Article and Find Full Text PDF

Unlabelled: Neonatal pneumothorax (NP) is a potentially life-threatening condition. Lung ultrasound (LUS) has shown higher sensitivity and specificity in diagnosis compared to x-rays, but evidence regarding its usefulness in complex NP is lacking. We report four neonates suffering from cardiac or esophageal malformations who developed lateral and/or posterior pneumothoraces, in which LUS helped, making NP diagnosis and management easier and faster.

View Article and Find Full Text PDF

We present a case of a 10-year-old male with Staphylococcus aureus mitral endocarditis who was initially misdiagnosed with multisystem inflammatory syndrome associated with coronavirus disease 2019, with eventual fatal outcome due to brain hemorrhage after cardiac intervention. Our case differs from recent studies, in which microbleeds did not increase the risk of hemorrhagic stroke or global mortality risk.

View Article and Find Full Text PDF

Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson's classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results.

View Article and Find Full Text PDF

Relationships between social withdrawal and facial emotion recognition in neuropsychiatric disorders.

Prog Neuropsychopharmacol Biol Psychiatry

March 2022

Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden University, The Netherlands; Amsterdam UMC, Vrije Universiteit and GGZ inGeest Research & Innovation, The Netherlands; Gregorio Marañon University Hospital, Spain.

Background: Emotion recognition constitutes a pivotal process of social cognition. It involves decoding social cues (e.g.

View Article and Find Full Text PDF
Article Synopsis
  • Youth with vertically acquired HIV (YWVH) show immune abnormalities despite being on antiretroviral treatment (ART), especially with heightened T-cell activation and exhaustion levels.
  • A study comparing YWVH to HIV-negative youth found strong correlations between immune activation markers and the CD4/CD8 ratio, suggesting this ratio may help in tracking disease progression.
  • Overall, ART appears to only partially restore normal immune function in YWVH, emphasizing the need for ongoing monitoring and adaptation of treatment strategies.
View Article and Find Full Text PDF
Article Synopsis
  • Research aimed to compare COVID-19 impacts between older adults in long-term care facilities (LTCF) and those living in the community, focusing on clinical and epidemiological differences, hospital management, and outcomes.
  • Among hospitalized patients aged 75 and older, LTCF residents were found to be older, more likely to have functional dependence, comorbidities, and dementia, and had shorter symptom durations than community-dwelling peers.
  • Key mortality risk factors for LTCF residents included severe functional dependence and hypoxia; however, after adjusting for other factors, their in-hospital mortality rate was lower than initially observed.
View Article and Find Full Text PDF

GEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was to analyze the characteristics and the impact of perinatal risk factors on BPD severity.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on adults with congenital heart disease (ACHD), who often suffer from heart failure (HF) due to past surgeries and require better treatment data to improve their care.
  • Researchers will collect data from a multi-country register, the ARTORIA-R, identifying ACHD patients listed for heart transplantation from 1989-2020, using both retrospective and prospective methods.
  • The goal is to track outcomes like clinical worsening, death on the waiting list, and overall mortality after transplantation to enhance understanding and management of advanced heart failure in this population.
View Article and Find Full Text PDF

Background: Distal minimally invasive metatarsal osteotomies have become increasingly popular. This technique requires fluoroscopic control, but recently, an ultrasound-guided procedure has been described. The aim of this anatomical study was to assess the quality safety of ultrasound-guided minimally invasive metatarsal osteotomies.

View Article and Find Full Text PDF

Background: Approximately 15% of patients infected by SARS-CoV-2 develop a distress syndrome secondary to a host hyperinflammatory response induced by a cytokine storm. Myelosuppression is associated with a higher risk of infections and mortality. There are data to support methods of management for neutropenia and COVID-19.

View Article and Find Full Text PDF