Innovative localized surface plasmon resonance sensing technique for a green spectrofluorimetric assay of ketoprofen, paracetamol and chlorzoxazone in pharmaceutical preparations and biological fluids.

A green, quick and sensitive spectrofluorimetric technique was investigated and validated for the assay of three different drugs namely, ketoprofen (KPN), paracetamol (PAR), and chlorzoxazone (CLX). The method is based on fluorescence quenching of the fluorescence probe, silver nanoparticles (SNPs). The fluorescence quenching of SNPs may be attributed to the complexation between each of the studied drugs with SNPs.