Click-designed vanilloid-triazole conjugates as dual inhibitors of AChE and Aβ aggregation.

Based on their reported neuroprotective properties, vanilloids provide a good starting point for the synthesis of anti-Alzheimer's disease (AD) agents. In this context, nine new 1,2,3-triazole conjugates of vanilloids were synthesized click chemistry. The compounds were tested for their effect on acetylcholine esterase (AChE) and amyloid-beta peptide (Aβ) aggregation.

Versisterol, a new endophytic steroid with 3CL protease inhibitory activity from (Forssk.) Vierh.

A new epoxy ergostane sterol, named versisterol, was isolated from , an endophytic fungus from . The structure of the isolated compound was deduced by means of one- and two-dimensional NMR and high-resolution mass spectrometry. The absolute stereochemistry was elucidated by NOESY analysis, and experimental and calculated time-dependent density functional theory (TD-DFT) circular dichroism spectroscopy.