The Added Value of Apparent Diffusion Coefficient and Histogram Analysis in Assessing Treatment Response of Locally Advanced Cervical Cancer.

Objective: The aim of the study is to assess the diagnostic performance of quantitative analysis of diffusion-weighted imaging in assessing treatment response in cervical cancer patients.

Methods: A retrospective analysis was done for 50 patients with locally advanced cervical cancer who received concurrent chemoradiotherapy and underwent magnetic resonance imaging and diffusion-weighted imaging. Treatment response was classified into 4 categories according to RECIST criteria 6 months after therapy completion.

Anti-hepatocellular carcinoma activities of novel hydrazone derivatives downregulation of interleukin-6.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related morbidity worldwide. Sorafenib is a first-line drug for the treatment of HCC, however, it is reported to cause serious adverse effects and may lead to resistance in many patients. In this study, 20 hydrazone derivatives incorporating triazoles, pyrazolone, pyrrole, pyrrolidine, imidazoline, quinazoline, and oxadiazine moieties were designed, synthesized, and characterized.

Introduction to the Young African Researchers collection.

Abisola O. Egbedina, Jairus L. Lamola, Mina Shawky Adly, and Stephen O.

Expression of concern: Effectiveness of some novel heterocyclic compounds as corrosion inhibitors for carbon steel in 1 M HCl using practical and theoretical methods.

Expression of concern for 'Effectiveness of some novel heterocyclic compounds as corrosion inhibitors for carbon steel in 1 M HCl using practical and theoretical methods' by Abd El-Aziz S. Fouda , , 2021, , 19294-19309, https://doi.org/10.

Expression of concern: Experimental and surface morphological studies of corrosion inhibition on carbon steel in HCl solution using some new hydrazide derivatives.

Expression of concern for 'Experimental and surface morphological studies of corrosion inhibition on carbon steel in HCl solution using some new hydrazide derivatives' by Abd El-Aziz S. Fouda , , 2021, , 13497-13512, https://doi.org/10.

12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29.

Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate network of cellular and molecular mechanisms. This study sought to explore the mechanisms by investigating the role of 12-hydroxyeicosatetraenoic acid (12-HETE), its receptor GPR31, and microRNA (miR-29) in the context of DR, specifically focusing on their impact on Müller glial cells. We found that 12-HETE activates Müller cells (MCs), elevates glutamate production, and induces inflammatory and oxidative responses, all of which are instrumental in DR progression.

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review.

Nanocomposite hydrogel biomaterials represent an exciting Frontier in biomedicine, offering solutions to longstanding challenges. These hydrogels are derived from various biopolymers, including fibrin, silk fibroin, collagen, keratin, gelatin, chitosan, hyaluronic acid, alginate, carrageenan, and cellulose. While these biopolymers possess inherent biocompatibility and renewability, they often suffer from poor mechanical properties and rapid degradation.

Smart biomaterials for enhancing cancer therapy by overcoming tumor hypoxia: a review.

Hypoxia is a distinctive feature of most solid tumors due to insufficient oxygen supply of the abnormal vasculature, which cannot work with the demands of the fast proliferation of cancer cells. One of the main obstacles to limiting the efficacy of cancer medicines is tumor hypoxia. Thus, oxygen is a vital parameter for controlling the efficacy of different types of cancer therapy, such as chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy (IT), and radiotherapy (RT).

Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP-HO nanofibers, characterization, and bio-evaluation tests.

Released oxygen plays a critical role in reducing destructive tumor behavior. This study aims to utilize decomposed hydrogen peroxide as an oxygen source by conjugating it with polyvinylpyrrolidone (PVP). PVP-hydrogen peroxide complex (PHP) composed of different ratios of (PVP : HO) (0.

Effectiveness of some novel heterocyclic compounds as corrosion inhibitors for carbon steel in 1 M HCl using practical and theoretical methods.

Corrosion of carbon steel is a major problem that destroys assists of industries and world steel installations; the importance of this work is to introduce new heterocyclic compounds as effective and low-cost corrosion inhibitors. Three compounds of carbohydrazide derivatives, namely: 5-amino-'-((2-methoxynaphthalen-1-yl)methylene)isoxazole-4-carbohydrazide (H4), 2,4-diamino-'-((2-methoxy-naphthalene-1-yl)methylene) pyrimidine-5-carbohydrazide (H5) and '-((2-methoxynaphthalen-1-yl)methylene)-7,7-dimethyl-2,5-dioxo-4,5,6,7,8,8-hexahydro-2-chromene-3-carbohydrazide (H6) were used to examine the efficacy of corrosion of carbon steel in 1 M hydrochloric acid solution. This corrosion efficacy was detected by utilizing various methods including electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), weight loss measurements (WL), surface morphology analyses by atomic force microscopy (AFM), quantum chemical computations based on density functional theory (DFT) and molecular dynamics (MD) simulation.

Chitosan nanocomposites with CdSe/ZnS quantum dots and porphyrin.

Water-soluble nanocomposites based on CdSe/ZnS quantum dots (QDs) and hydrophobic tetraphenylporphyrin (TPP) molecules passivated by chitosan (CS) have been formed. Magnetic circular dichroism (MCD) spectra evidence TPP presence in both monomeric and agglomerated forms in the nanocomposites. The nanocomposites demonstrate more pronounced singlet oxygen generation compared to free TPP in CS at the same concentration due to the intracomplex Förster resonance energy transfer (FRET) with a 45% average efficiency.

Experimental and surface morphological studies of corrosion inhibition on carbon steel in HCl solution using some new hydrazide derivatives.

The corrosion inhibition of C-steel in 1 M HCl was assessed using three newly synthesized hydrazide derivatives (H1, H2 and H3) using weight loss (WL), potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) techniques. Also, the adsorption of these compounds was confirmed using several techniques such as atomic force microscopy (AFM), Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). High inhibition efficiencies were obtained resulting from the constitution of the protective layer on the C-steel surface, which increased with increasing concentration and temperature and reached 91.

Mandibular symphysis dimensions in different sagittal and vertical skeletal relationships.

Background: The aim of this cross-sectional study was to compare the dimensions of mandibular symphysis (MS) between gender and the different sagittal and vertical skeletal relationships.

Material And Methods: Pre-treatment records of orthodontic patients were divided according to gender, sagittal (Class I, II and III) and vertical (decreased, average and increased mandibular plane [MP] angle) skeletal relationships. Measurements of MS parameters were performed on lateral cephalograms using IMAGEJ software.

Optical and dielectric characteristics of polyethylene oxide/sodium alginate-modified gold nanocomposites.

Films of polyethylene oxide and sodium alginate polymer blend (50/50 wt%) embedded with different quantities of Au nanoparticles with size 3-32 nm were made using the casting process. The nanocomposite films were examined by XRD analysis, FT-IR spectroscopy, TEM, UV/vis spectroscopy, and AC conductivity and dielectric parameter measurements. The XRD spectra revealed the amorphous nature of the prepared films (PEO/SA-Au NPs).

Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration.

Disruption of retinal pigment epithelial (RPE) barrier integrity and RPE migration are hallmark features in neovascular age-related macular degeneration (nAMD), but the underlying causes and pathophysiology are not completely well-defined. Herein, we aimed to evaluate the effect of bone morphogenetic proteins (BMPs) on the barrier function and migration of RPE. In particular, we investigated the role of BMP2 and BMP4 in these processes as our analysis of RNA-sequencing (seq) data from human donor eyes demonstrated that they are highly differentially expressed BMP members in macular RPE/choroid versus macular retina.

Prognostic value of CD25/CD123 pattern of expression in acute myeloid leukemia patients with normal cytogenetic.

This study was designed to assess the significance of interleukin-2 receptor (CD25) and inteleukin-3 receptor (CD123) expression in cytogenetically normal acute myeloid leukemia (CN-AML) patients. The current study includes 80 CN-AML (≤ 60 years) before the start of therapy. Blast cells expression for CD25 and CD123 were identified by flowcytometry in fresh bone marrow samples.

Case report; meta-synchronous triple malignancy in primary diagnosed CML patient.

The diagnosis of different types of cancer in a single patient has been appeared in the field in some case reports involving different categories of cancer types either appeared at the same time (synchronous) or subsequently (meta-synchronous). The aim of this report is to present this interesting case of male patient who was under treatment of CML then T-lymphoblastic lymphoma and HCC discovered subsequently. CML, Lymphoma and HCC are arising from different lines of cells with different biology and cytogenetic criteria.

Prevalence of inducible laryngeal obstruction among patients diagnosed as bronchial asthma.

Introduction: Inducible laryngeal obstruction (ILO) is an important cause of a variety of respiratory symptoms and can mimic bronchial asthma (BA). This study was planned to measure the prevalence of ILO among patients diagnosed with BA and to detect its effect on BA control and severity.

Material And Methods: Patients aged 18 years or older who were previously diagnosed with BA were enrolled.

Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: Correlation between Androgen Receptor Expression and Pathological Response.

Background: There is growing evidence that the response to chemotherapy may be affected by Androgen Receptor (AR) expression suggesting that triple-negative breast cancers (TNBC) AR+ and quadruple negative breast cancer (QNBC) subtypes may have different diseases behavior.

Methodology: We retrospectively estimated the predictive value of the AR expression in stage II and stage III TNBC patients treated with neoadjuvant chemotherapy (NAC) and correlated with the rate of pathological response (pCR).

Results: Of 89 TNBC patients, 29 patients (32.

Xeno-free trans-differentiation of adipose tissue-derived mesenchymal stem cells into glial and neuronal cells.

Mesenchymal stem cells (MSCs) are undifferentiated cells that have the ability of self-renewal and trans-differentiation into other cell types. They hold out hope for finding a cure for many diseases. Nevertheless, there are still some obstacles that limit their clinical transplantation.

An international perspective on hospitalized patients with viral community-acquired pneumonia.

Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.

Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP.

A Novel Combination of C-Reactive Protein and Vascular Endothelial Growth Factor in Differential Diagnosis of Ascites.

Background And Aims: Ascites with unknown cause remains a diagnostic challenge, which needs novel noninvasive biomarkers for the precise diagnosis. We aimed to evaluate the ascitic fluid and serum C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) as diagnostic markers in the differential diagnosis of malignant and benign ascites.

Methods: In this prospective work, 315 consecutive patients with ascites were studied.

Effect of different doses of monosodium glutamate on the thyroid follicular cells of adult male albino rats: a histological study.

Monosodium glutamate (MSG) is a major flavor enhancer used as a food additive. The present study investigates the effects of different doses of MSG on the morphometric and histological changes of the thyroid gland. 28 male albino rats were used.

Erratum to: caustic ingestion management: world society of emergency surgery preliminary survey of expert opinion.

[This corrects the article DOI: 10.1186/s13017-015-0043-4.].