Multi-target directed ligands inspired natural products as an effective approach for the treatment of complex chronic health disorders.

Complex diseases involve multifaceted etiological components, which limit the effectiveness of conventional targeted therapies. Therefore, standard medicinal treatments often face significant challenges and failures when addressing these disease conditions. Furthermore, the growing interest in multidrug resistance (MDR), the occurrence of adverse drug reactions related to use traditional approaches, and the limited clinical efficacy of single-target drug therapy have increased the demand for innovative drug treatments.

High-Throughput Microarray Approaches for Predicting the Stability of Drug-Polymer Solid Dispersions.

Amorphous solid dispersions (ASDs) offer a well-recognized strategy to improve the effective solubility and, hence, bioavailability of poorly soluble drugs. In this study, we developed an extensive library of a significant number of solid dispersion formulations using a library of chemically diverse drugs combined with a water-soluble polymer (polyvinylpyrrolidone vinyl acetate, PVPVA) at different loadings. These formulations were printed as microarrays of solid dispersion formulations, utilizing minimal material amounts (nanograms).

Association between FTO gene polymorphism and obesity in down syndrome children.

Unlabelled: Children with Down syndrome (DS) have a higher incidence of overweight and obesity compared to typically developing peers. The fat mass and obesity-associated gene (FTO) is one of the early identified genes linked to obesity in various populations. To date, the FTO rs17817449 gene polymorphism has not been investigated in overweight/obese-DS (ODS) individuals.

The Feasibility of Measuring Central Blood Pressure with Bedside Echocardiography: An Observational Cross-Sectional Study.

Rationale And Objectives: Central arterial blood pressure (CBP) is considered a more valuable prognostic marker of major cardiovascular diseases than peripheral blood pressure. Non-invasive evaluation of central aortic pressure by Doppler echocardiography is a hopeful tool, avoiding many complications of invasive catheter strategy and diminishing time and costs.

Methods: A total of 118 patients were referred for elective cardiac catheterization at the Cardiovascular Medicine Department, Mansoura University.

Effectiveness of clear aligner versus removable inclined plane in treatment of anterior crossbite in mixed dentition: A randomized clinical trial.

Background: This study aimed to compare the efficacy of clear aligners and removable inclined planes (RIP) in management of anterior crossbite in late mixed dentition patients using a 3D digital model.

Materials And Methods: Twenty-four patients with functional anterior crossbite, aged 8 to 12 years old, were randomly assigned to two parallel groups: the clear aligner (CA) group with a mean age of 10.74 ± 1.

Decorin alleviates non-alcoholic fatty liver disease in rats with polycystic ovary syndrome.

Endocrine multisystem defect polycystic ovary syndrome (PCOS) causes hyperandrogenism and infertility. Half of PCOS women have (non-alcoholic fatty liver disease) NAFLD, which increases metabolic disease risk. We tested decorin's effect on NAFLD and related processes in PCOS.

The Implications for Clinical Practice of Circulating miR144-3p and miR190a-5p as Promising Diagnostic Biomarkers for Thyroid Nodule Differentiation.

Background And Aims: Thyroid cancer, a prevalent endocrine malignancy, often presents as thyroid nodules, whose benign or malignant nature is challenging to determine. This study aims to identify circulating miRNA panels that may distinguish between benign nodules, papillary thyroid cancer, and normal thyroid conditions, building on extensive research into miRNAs as potential thyroid cancer biomarkers.

Materials And Methods: As a cross-sectional case-control study the study revealed the quantification of the 17-miRNA panel was evaluated using qRT-PCR method on 60 blood samples, comprising 25 patients diagnosed with PTC, 24 patients with benign lesions, and 11 healthy controls.

Comparison between the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and their combination on mortality in maintenance dialysis patients: a systematic review and meta-analysis.

Introduction: Patients undergoing maintenance dialysis have a higher mortality rate compared to the general population. It is known that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have protective effects on the kidney; however, few studies have directly compared their impact on mortality in patients undergoing dialysis. This study aims to evaluate the effectiveness of ACEIs, ARBs, or their combination in reducing all-cause and cardiovascular mortality in maintenance dialysis patients.

Efficacy and safety of tenapanor vs placebo in treating CKD patients on dialysis and with hyperphosphatemia: a systematic review and meta-analysis of 2251 patients.

Background: Hyperphosphatemia is common in chronic kidney disease (CKD) patients, especially patients on hemodialysis. Tenapanor is a novel drug with fewer side effects and high compliance compared to traditional phosphate binders. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of tenapanor.

Safety and efficacy of dasotraline for patients with attention deficit/hyperactivity disorder: a systematic review and meta-analysis of 1594 patients including GRADE qualifications.

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder. It is one of the most common mental disorders in youth worldwide characterized by persistent overactivity and impulsivity/inattention symptoms associated with social and academic impairment. dasotraline has been suggested to play a pivotal role as a serotonin, norepinephrine, and dopamine reuptake inhibitor.

Novel therapeutic target for diabetic kidney disease through downregulation of miRNA-192-5p and miRNA-21-5p by celastrol: implication of autophagy, oxidative stress, and fibrosis.

One of the most common microvascular effects of diabetes mellitus (DM) that may result in end-stage renal failure is diabetic kidney disease (DKD). Current treatments carry a substantial residual risk of disease progression regardless of treatment. By modulating various molecular targets, pentacyclic triterpenoid celastrol has been found to possess curative properties in the treatment of diabetes and other inflammatory diseases.

Comparative analysis of laparoscopic, retro-muscular, and open mesh repair techniques for ventral and incisional hernias: a comprehensive review and meta-analysis.

Ventral hernias are abnormalities in anterior abdominal wall occurring due to an incision or are congenital. This comprehensive review and meta-analysis aim to objectively compare laparoscopic to retro-muscular or any other mesh repair approach to manage ventral incisional hernia. To identify studies that managed ventral incisional hernia using laparoscopic, open, or retro-muscular mesh repair techniques, a comprehensive literature search was performed.

Facile synthesis of novel nanocomposite composed of CoO, MgO, and MgBO for malachite green dye decontamination from aqueous media.

Malachite green is a hazardous chemical that poses serious threats to aquatic ecosystems due to its toxicity and persistence in the environment. Additionally, it is harmful to human health, recognized as a carcinogenic and mutagenic agent that can cause long-term adverse effects. Hence, in this study, malachite green dye was efficiently removed from aqueous media using CoO/MgO/MgBO novel nanocomposites, known as CBM600 and CBM800.

Tailoring nursing interventions to empower patients: personal coping strategies and self-management in type 2 diabetes care.

Background: Diabetes is one of the most common chronic diseases that severely reduce a patient's quality of life. Effective self-care and management are critical for maintaining blood glucose levels and preventing complications.

Aim: This study evaluates the effectiveness of a structured diabetes self-management education program on patients' self-management behaviors, empowerment, and activation levels.

Effect of using heart of date palm as a new source of protein, carbohydrates, and bioactive compounds on the characterization of low-fat camel milk ice cream.

The heart of the date palm is a nutrient-rich vegetable found at the center of palm trees, abundant in protein and dietary fiber, primarily made up of carbohydrates. Preliminary studies indicate that the heart of the date palm possesses healing properties, exhibiting potent cytotoxic effects against HepG2 cells, suggesting its potential in cancer treatment. A low-fat ice cream was created using camel milk, enriched with varying amounts of heart of date palm-4 %, 8 %, and 12 % of the mix-as a source of bioactive compounds, protein, and carbohydrates.

Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Unlabelled: Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. We hypothesize that MEVs cross host cellular barriers and deliver their cargoes of bioactive compounds to the brain.

Cannabidiol Suppresses Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence through Modulating Tryptophan Catabolism.

Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive phenotype of prostate cancer (PC). Tryptophan oxidative catabolism by indoleamine 2,3-dioxygenase-1 (IDO1) cleaves the indole ring to kynurenine (Kyn), an endogenous ligand for the aryl hydrocarbon receptor (AhR), which activates multiple tumorigenesis pathways. The IDO1-Kyn-AhR axis is aberrantly dysregulated in mCRPC.

Evaluation of modified essay questions (MEQs) as an assessment tool in third-year medical students' modular summative assessment.

Aim: Whether case-based modified essay questions (MEQs) are crucial to summative assessment in medical curriculum is still debatable. The current study aimed to evaluate third-year medical students' performance in case-based MEQs and multiple-choice questions (MCQs) in summative assessment in the endocrine module.

Methods: Students' scores in mid and final module MEQs and MCQs were analyzed over four successive years from 2018/2019 to 2021/2022, where comparisons were made between students' scores in MEQs and MCQs, and between scores of students of different categories.

Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment.

This study explores an eco-friendly approach to mitigate risks associated with organophosphorus insecticides, particularly Chlorpyrifos, by synthesizing silver nanoparticles (AgNPs) using Psidium guajava leaf extract and preparing a nanocomposite (AgNPs/S18) with Chlorpyrifos pesticide. The green-synthesized AgNPs and AgNPs/S18 nanocomposite were characterized using various analytical techniques, confirming the successful synthesis of AgNPs with an average size of 37 nm and forming a stable nanocomposite. Antibacterial assays demonstrated significant activity against Staphylococcus aureus, with AgNPs showing an 87.

Assessing caregiver stress and resource needs in pediatric cancer care.

Background: Caregivers of pediatric cancer patients often face significant stress and emotional strain, which can negatively impact their well-being and the quality of care provided to their children. Understanding the socio-demographic factors influencing caregiver stress and identifying the specific needs and resources required by caregivers are crucial for improving support systems in pediatric cancer care.

Aim Of The Study: This study aimed to analyze the levels of caregiver stress and their resource needs within pediatric cancer care.

Satisfaction of academic medical staff with integrated medical curriculum: an exploratory multinational survey.

Background: The adoption of integrated curricula in medical schools has grown globally, emphasizing the need to understand academic medical staff satisfaction as a crucial factor influencing successful implementation.

Aim: This study aimed to assess satisfaction levels among academic medical staff with integrated medical curricula, identifying socio-demographic and work-related predictors of dissatisfaction.

Methods: A cross-sectional, online multinational survey was conducted from December 2023 to April 2024 among 525 academic medical staff.

Bonding super translucent multilayered monolithic zirconia to different foundation materials: an invitro study.

Background: The objective of this study was to investigate the effect of bonded substrate, zirconia surface conditioning and the interaction between them on the shear bond strength of monolithic zirconia.

Methods: Forty-eight monolithic zirconia discs were CAD-CAM fabricated and divided into two groups according to surface treatment either as milled and universal primer application (Monobond N, Ivoclar-Vivadent) (P) or sandblasting then universal primer application (Monobond N) (SP). Each main group was further divided into three test groups according to the bonded substrate: dentin (DSP, DP), composite (CSP, CP) or resin modified glass ionomer (RMGI) (GSP, GP).

Comparative efficacy, safety, and oncological outcomes of percutaneous thermal and chemical ablation modalities for recurrent metastatic cervical lymphadenopathy from thyroid cancer.

Background: Thermal and chemical ablation techniques may consolidate recurrent metastatic cervical lymph nodes as alternatives to repeat neck dissection in thyroid cancer patients. This meta-analysis aims to compare the efficacy and safety across modalities.

Methods: Four databases were searched for studies on radiofrequency (RFA), microwave (MWA), laser (LA), and ethanol ablation (EA) treating metastatic cervical nodes from thyroid cancer.

Development and internal validation of El-Shazly-Buchholz's nomogram to predict postoperative complications after PCNL: A multicenter study.

Introduction: A model to predict the risk of surgical complications following percutaneous nephrolithotomy (PCNL) could be a useful tool to guide clinical decision-making. The aim of this study was to develop a simple and widely applicable stratification tool to be used for patient counseling, surgical planning, evaluation of outcomes, and academic reporting.

Methods: Data of patients who underwent PCNL were retrieved from the database of the collaborating centers including demographics of patients, characteristics of their stones and urinary tracts, and perioperative data.