Surgical and Nonsurgical Lines of Treatment of Reinke's Edema: A Systematic Literature Review.

Objectives: The aim of this study was to carry out a systematic review of different surgical and nonsurgical lines of treatment of Reinke's edema to identify the effectiveness and the guidelines described to use each of them.

Methods: We searched PubMed and Coherence for randomized controlled trials and case reports studies did on adult humans aged from 18 to 80 years, from January 1997 to December 2018. We included studies that treated patients with Reinke's edema by one and/or combinations of the following interventions: cold steel microlaryngeal phonosurgery, microdebrider, CO laser, photoangiolytic laser, voice therapy, Steroid and Hyaluronidase injection.