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Meta-Analytic Operation of Threshold-independent Filtering (MOTiF) reveals sub-threshold genomic robustness in trisomy: The Jörmungandr Effect.
Biochem Biophys Res Commun
December 2024
Manning College of Information and Computer Sciences University of Massachusetts, Amherst Amherst, MA 01003-9264, USA. Electronic address:
Article Synopsis
- Trisomy, a type of abnormal chromosome count linked to cancer, shows varied cellular effects due to differences in thresholds used in research.
- To address these discrepancies, the researchers introduced a method called MOTiF, which analyzes data without relying on predetermined thresholds and uncovers the underlying mechanisms influencing gene expression.
- Applying MOTiF to human colonic cells revealed a consistent decrease in gene expression linked to a structural genomic change, named the Jörmungandr Effect, suggesting a potential adaptive response to the extra chromosome, although further research is needed to confirm this effect.