29 results match your criteria: "Mannheim Cancer Center MCC[Affiliation]"
Prognostic Significance of Bone Metastasis in Soft Tissue Sarcoma Patients Receiving Palliative Systemic Therapy: An Explorative, Retrospective Pooled Analysis of the EORTC-Soft Tissue and Bone Sarcoma Group (STBSG) Database.
Sarcoma
April 2022
Sarcoma Unit, Mannheim University Medical Center, Mannheim Cancer Center (MCC), University of Heidelberg, Mannheim, Germany.
Background: Soft-tissue sarcomas (STS) constitute a rare group of heterogeneous mesenchymal tumours containing more than 100 histologic subtypes. Here, we investigate whether, and if so, to what extent, skeletal metastases affect the outcome of patients with advanced or metastatic disease.
Materials And Methods: Selected patients participated in five clinical trials of EORTC-STBSG.
Preferential translation of p53 target genes.
RNA Biol
April 2022
Division of Biochemistry Mannheim Institute for Innate Immunoscience (MI3) and Mannheim Cancer Center (MCC), Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.
The transcription factor p53 exerts its tumour suppressive effect through transcriptional activation of numerous target genes controlling cell cycle arrest, apoptosis, cellular senescence and DNA repair. In addition, there is evidence that p53 influences the translation of specific mRNAs, including translational inhibition of ribosomal protein synthesis and translational activation of MDM2. A challenge in the analysis of translational control is that changes in mRNA abundance exert a kinetic (passive) effect on ribosome densities.
View Article and Find Full Text PDFGlobal Patient Involvement in Sarcoma Care-A Collaborative Initiative of the Connective Tissue Oncology Society (CTOS) & Sarcoma Patients EuroNet (SPAEN).
Cancers (Basel)
February 2022
Department of Radiotherapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Sarcomas are a grouping of rare cancers with a wide variety of histological types that are difficult to diagnose and treat. This leads to many varying challenges not only for sarcoma patients, but also for doctors, researchers, and caregivers. Patient advocacy groups have an important role to play in rare cancers such as sarcomas, especially in collaboration with experts and their medical societies.
View Article and Find Full Text PDFNeglected geriatric assessment and overtreatment of older patients with pancreatic cancer - Results from a prospective phase IV clinical trial.
J Geriatr Oncol
June 2022
Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Mannheim Cancer Center (MCC), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:
Article Synopsis
- Older patients with metastatic pancreatic cancer may face higher toxicity from aggressive chemotherapy, and using geriatric assessments (GA) can help tailor their treatment plans.
- A multicenter trial categorized patients into three groups (Go-Go, Slow-Go, Frail) based on GA scores to guide therapy decisions; however, recruitment issues led to early trial termination with only 32 participants.
- The findings showed a significant mismatch between treatment assigned and patients' GA categories, which may indicate overtreatment, highlighting the need for better alignment between clinical evaluations and geriatric assessments in managing this patient population.