Bioefficacy, chromatographic profiling and drug-likeness analysis of flavonoids and terpenoids as potential inhibitors of H1N1 influenza viral proteins.

Considering medicinal plants, natural products present in these plants are the best sources of medications for combating viral infection. The possible drug target against viral H1N1 influenza proteins lead to identification of selected secondary metabolites from potential plants Tinospora cordifolia, Ocimum sanctum, and Piper nigrum. On analysis of in vitro cell based antiviral activity of the selected plant extracts, an indication for a possible lead compound against neuraminidase activity was evident.

Novel environmental applications of green tea: sensing and remediation of Ag in aqueous system.

The strong fluorescence of green tea was quenched with Fe because of ligand-to-metal charge transfer and subsequent formation of magnetite (FeO) nanoparticles (heavy metal effect). Ag restored the lost fluorescence by confining iron particles (capped with Cl) with the formation of AgCl. Thus, toxic Ag was sensed in the aqueous system with a linear detection range of 10 M to 10 M and a detection limit of 4.

Pharmacokinetic model-guided enoxaparin dosing in the Neonatal ICU: Retrospective cohort study to plan for prospective feasibility trial.

Traditional milligram per kilogram (mg/kg) dosing of enoxaparin in neonates frequently fails to achieve target anti-Xa levels promptly, necessitating repeated laboratory monitoring and dose adjustments. This study investigated whether a personalized dosing strategy based on predicted individual clearance and volume of distribution could improve outcomes, comparing standard-of-care (SOC) mg/kg dosing to pharmacokinetic (PK) model-informed precision dosing (MIPD). A retrospective analysis was conducted on hospitalized neonates treated with enoxaparin at less than 44 weeks postmenstrual age from 2019 to 2022.

Patient considerations for orthodontists: A comparative study of university students in Malaysia and Taiwan.

Background/purpose: Patients' considerations when choosing an orthodontist are influenced by many factors, including background, ethnicity, and location. Accordingly, this study aimed to identify factors influencing patients' considerations when selecting an orthodontist in both Malaysia and Taiwan.

Materials And Methods: In total, 248 dental students from Taipei Medical University and 110 dental students from Manipal University College Malaysia were selected for this study.

Microplastics release from coronary catheters: Insights from catheter analysis.

Microplastics (MP) pose a significant environmental and health risk due to their pervasive presence and potential adverse effects. This study investigates the release of MP from cardiac invasive catheters, which are essential medical devices used in cardiovascular procedures. Twenty-one catheter samples from four diagnostic catheter and three guider catheter brands were analysed using a comprehensive experimental approach.

Decreased Expression of CD247 and CD4 Immune Marker Predicts Poor Prognosis in Triple Negative Breast Cancer.

Objective: Triple negative breast cancer (TNBC) is an aggressive from of breast cancer and is associated with poor prognosis. Tumor microenvironment of breast cancer consists of a wide   range of cell types, including tumor-infiltrating lymphocytes (TILs). Accumulating evidence indicate that TILs play a crucial role in cancer progression and resistance to standard chemotherapy.

UICE-MIRNet guided image enhancement for underwater object detection.

Underwater object detection is a crucial aspect of monitoring the aquaculture resources to preserve the marine ecosystem. In most cases, Low-light and scattered lighting conditions create challenges for computer vision-based underwater object detection. To address these issues, low-colorfulness and low-light image enhancement techniques are explored.

Differential Analysis of Heart Rate Variability in School Going Adolescents: Comparing Healthy Individuals with Those Experiencing Depression and Anxiety.

Background Adolescents often struggle with depression and anxiety, which can greatly affect their well-being and functioning. Early detection is crucial for timely intervention and long-term health. Objective The objective of this study is to compare heart rate variability between depressed and anxious adolescents and their healthy peers.

Iodine/DMSO-catalyzed oxidative deprotection of -tosylhydrazone for benzoic acid synthesis.

An oxidative deprotection of tosylhyrdazones has been demonstrated to afford benzoic acids using iodine and DMSO system. This efficient oxidative deprotection protocol offers exceptional functional group toleration under mild reaction conditions without any initiators or bases. Notably, the tosylhydrazone with the heteroaryl ring or with the aryl ring having base-sensitive hydroxyl and ester functional groups smoothly afforded the corresponding benzoic acid analogues under developed conditions.

The Indirect Effect of an Internet-Based Intervention on Third-Party Disability for Significant Others of Individuals with Tinnitus.

Background: This study aimed to investigate whether Internet-based cognitive behavioural therapy intervention (ICBT) for individuals with tinnitus had an indirect effect on the third-party disability noticed by significant others (SOs).

Methods: Significant Others Questionnaire (CTSOQ). Individuals with tinnitus completed standardized self-reported outcome measures for tinnitus severity, anxiety, depression, insomnia, hearing-related quality of life, tinnitus cognitions, hearing disability, and hyperacusis.

Targeted inhibition of NRF2 reduces the invasive and metastatic ability of HIP1 depleted lung cancer cells.

Background: Non-Small Cell Lung Cancer (NSCLC) presents as a highly metastatic disease with Kras and P53 as prevalent oncogenic driver mutations. Endocytosis, through its role in receptor recycling and enrichment, is important for cancer cell proliferation and metastasis. Huntingtin Interacting Protein 1 (HIP1) is a clathrin mediated endocytic adapter protein found overexpressed in different cancers.

Synergism between copper and silver nanoclusters induces fascinating structural modifications, properties, and applications.

Among the group 11 transition metal elements, Cu and Ag are widely studied due to their cost effectiveness and easy availability. However, the synergism between copper and silver is also very promising, exhibiting intriguing structures, properties, and applications. Nanoclusters, which are missing links between atoms and nanoparticles, are highly fluorescent due to their discrete energy levels.

Questionnaire-Based Study on the Knowledge of Cervical Cancer and Attitude and Perception Toward Self-Sampling Method of Screening, Among Women in Sikkim, India.

Background: Cervical cancer (CC) is the second most common cancer among women in India and in Sikkim. Screening helps in prevention and early detection of the disease; however, pelvic examination for smear collection is not preferred by many. Self-sampling method can be a good alternative for collection of smears, thus increasing screening uptake.

Anatomical and Developmental Abnormalities of Ureters and Renal Pelvis Existing with Accessory Renal Arteries: Cadaveric Study.

Background: Anatomical and developmental variations of ureters and renal pelvis have been observed frequently during routine human cadaveric dissection and surgical practice; however, their coexistence with accessory or aberrant renal arteries is exceptionally rare. Accordingly, this study was designed to evaluate the prevalence of anatomical and developmental abnormalities of ureters and renal pelvis existing with accessory renal arteries in human cadavers.

Materials And Methods: This study was carried out on 50 human cadavers including dissected specimens (25 males and 25 females) the kidneys, renal pelvis, and ureters along with their arteries were exposed and the anomalous abnormalities of the renal pelvis and ureters existing with accessory renal arteries were observed.

Rational design of Boerhavia diffusa derived CoFeO-Carbon dots@Boehmite platform for photocatalysis and ultra trace monitoring of hazardous pesticide and UO ions.

In view of exploiting natural resources for designing of effectual materials in favor of detection and obliteration of water pollutants, a fluorescent nanomaterial (CDBHCF) based on biomass derived carbon dots (CDs) was constructed. The CDs and cobalt ferrite (CF) particles were anchored on boehmite (BH) which served as a support material for CDs. The CDBHCF nanocomposite was prepared via facile hydrothermal treatment for selective recognition of Methyl parathion (MP) pesticide and uranyl ions (UO).

Acceleration of ion phase-space holes due to interactions with ion solitons in a wave-guided plasma.

Ion phase-space holes are solitary kinetic structures found in the ion phase-space of collision-less plasmas, and are nonlinear solutions to the Vlasov-Poisson equations, identified as Bernstein-Greene-Kruskal (BGK) modes. In this study, interactions between an ion phase-space hole and a travelling ion KdV soliton is presented. This interaction, which is simulated in a fully ionised highly magnetised plasma within a cylindrical wave-guide, exhibits acceleration and deacceleration of the ion hole, depending on its mode of collision with the travelling ion soliton.

Chaperone in breast examination: a comprehensive systematic review of patient and clinician perspectives, and documentation.

Background: The General Medical Council (GMC) has made it mandatory to have a chaperone present during intimate examinations, including breast exams, highlighting the importance of medicolegal protection for both patients and clinicians.

Aims: The use of chaperones during breast examinations is logical, especially in an increasingly litigious society. This review aims to summarize current information regarding patients' and clinicians' perspectives on chaperone use in breast examination.

Amniotic membrane graft (AMG) for persistent epithelial defects following infective corneal ulcers and keratitis - A systematic review.

Management of nonhealing corneal ulcers is challenging as it can lead to complications such as melting, descemetocele, and perforation, which can be prevented by amniotic membrane graft (AMG). The absence of any review (English language) on AMG for corneal ulcers prompted us to conduct this review. We looked for clinical trials (randomized and controlled) on the effect of AMG combined with other treatments, through various search engines utilizing the terms amniotic membrane and corneal ulcer.

Effects of Yoga on Stress in Pregnant Women.

During pregnancy, a woman's body undergoes physiological and metabolic changes to nourish the developing fetus. Every woman experiences pregnancy-related stress differently, with symptoms and difficulties ranging from mild to severe. However, various therapies are available to help reduce stress levels.

Developing a digital data platform for surveillance of food and water-borne pathogens in North East India: insight for public health advocacy.

Robust digital infrastructure is vital and the need of the hour, especially in the healthcare sector, for real-time data generation, analysis, and quick decision-making. Food- and water-borne illnesses represent a prominent cause of morbidity and mortality worldwide. India, a developing nation with diverse cultures and food practices, poses a high risk of food-borne diseases and outbreaks, yet is often underreported and ineffectively researched.

Comprehending the risk of foodborne and waterborne disease outbreaks: Current situation and control measures with Special reference to the Indian Scenario.

Background: Foodborne and waterborne diseases and outbreaks are a neglected public health issue worldwide. In developing countries, diarrheal disease caused by foodborne and waterborne infections is a major cause of ill health. There is a lack of information on foodborne pathogens, their transmission routes, outbreaks, and related mortalities, due to the absence of a robust disease surveillance system and adequately equipped laboratories.

Integrating the quintuple helix approach into atmospheric microplastics management policies for planetary health preservation.

Microplastic pollution has become a major global environmental issue, negatively impacting terrestrial and aquatic ecosystems as well as human health. Tackling this complex problem necessitates a multidisciplinary approach and collaboration among diverse stakeholders. Within this context, the Quintuple Helix framework, which highlights the involvement of academia, government, industry, civil society, and the environment, provides a comprehensive and inclusive perspective for formulating effective policies to manage atmospheric microplastics.

Fungal Peptidomelanin: A Novel Biopolymer for the Chelation of Heavy Metals.

Melanin is an amorphous, highly heterogeneous polymer found across all kingdoms of life. Although the properties of melanin can greatly vary, most forms are insoluble and strongly absorb light, appearing dark brown to black. Here, we describe a water-soluble form of melanin (peptidomelanin) secreted by the spores of (strain: melanoliber) during germination.