71 results match your criteria: "Manchester hospital[Affiliation]"

Postoperative stoma education is an essential aspect of care for all types of stoma formation because having a stoma impacts on every aspect of a person's life. This critical review of the literature explores stoma patients' needs and wants; postoperative education care guidelines; the role of ward link nurses; and care pathways. The findings from this review demonstrate that there is no national standard postoperative stoma care pathway, yet such pathways are a cost-effective means to improve patient outcomes and care.

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Factors affecting shared decision-making concerning menopausal hormone therapy.

Ann N Y Acad Sci

August 2024

Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

Menopausal hormone therapy (MHT) is an effective treatment for menopause-related symptoms. Menopause management guidelines recommend a personalized approach to menopause care, including MHT use. Decision-making around menopause care is a complex, iterative process influenced by multiple factors framed by perspectives from both women and healthcare providers (HCPs).

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  • CD4+ T cells are crucial for the immune system, but their exact function is not fully understood, particularly the role of the CD4 protein itself.
  • Researchers studied seven patients with a rare genetic condition causing CD4 deficiency, leading to various infections, and found that these individuals lacked CD4+ T cells but had alternative T cell populations that could still mount immune responses.
  • While the patients showed compensatory immune responses against many pathogens, CD4 remains essential for protection against specific infections like human papillomavirus and Whipple's disease.
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Smart match: revolutionizing organ allocation through artificial intelligence.

Front Artif Intell

February 2024

Department of Renal Transplant and General Surgery, Manchester Royal Infirmary, University Manchester Hospital NHS Foundation Trust, Manchester, United Kingdom.

In this transformative era of organ transplantation, integrating Smart Match and artificial intelligence (AI) emerges as a pivotal advancement, revolutionizing organ allocation processes. Smart Match employs AI algorithms, enhancing organ matching precision and optimizing transplantation outcomes. Leveraging machine learning addresses complexities in donor-recipient pairing, immunosuppression management, and post-operative care, promising to minimize waitlist mortality and improve patient wellbeing.

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  • - The integrated care pathways for atopic dermatitis (AD-ICPs) serve to connect existing treatment guidelines and expert insights into a structured plan that caters to different levels of AD severity and healthcare resources across various countries.
  • - Developed by the GA LEN ADCARE network and other stakeholders in 2020-2021, the AD-ICPs detail diagnostics, treatment options, and emphasize the roles of pharmacologists and other contributors in managing AD, particularly in pediatric cases.
  • - The initiative aims to enhance AD management through a multidisciplinary approach that addresses urgent needs like better access to care, specialist training, educational programs, and personalized treatments, ultimately leading to improved patient outcomes.
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  • * This study aimed to analyze the effectiveness and safety of DOACs specifically in obese patients with AF, using a thorough literature review which included 11 studies with over 144,500 patients.
  • * The findings revealed that apixaban was the most effective and safest DOAC for preventing strokes and major bleeding, outperforming rivaroxaban, dabigatran, and warfarin in this patient group.
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Background There are limited studies analyzing cutaneous lupus erythematosus (CLE) hospitalizations. In this study, we aimed to analyze baseline demographics of systemic lupus erythematosus (SLE) and CLE patients, identify the most common reasons for hospitalizations, and find out the hospitalization outcomes.  Materials and methods We performed the analysis using the National (Nationwide) Inpatient Sample (NIS) database between 2016 and 2019.

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Biopsies taken from the gastrointestinal tract (GIT) comprise a significant percentage of the pathologists' routine work. The variable histology and normal components of each organ along the GIT, as well as the different ways of responding to injury among these organs, can cause morphological changes that could result in potential diagnostic pitfalls. Herein, we review the pathological conditions of the GIT that could cause these diagnostic pitfalls.

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Background and objective Over the past few decades, new infectious diseases have emerged, and these have played a key role in changing behavior and lifestyle in all age groups. More recently, with the emergence of the coronavirus disease 2019 (COVID-19) pandemic, governments around the world have made unprecedented efforts to contain the epidemic by implementing quarantine measures, social distancing, and isolating infected individuals. Social behavioral adaptations (e.

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Introduction Communication is the exchange of information through speaking, writing, and other mediums. Speech is the expression of thoughts in spoken words. Language is the principal method that humans use for relaying information; consisting of words conveyed by speech, writing, or gestures.

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Learning from hospital deaths.

Med Leg J

March 2023

North Manchester Hospital, Manchester Foundation Trust, UK.

Current guidelines and regulations require trusts to take full responsibility for deaths within their premises. Higher than expected deaths indicate poor standards of care or negligence. NHS Trusts need to put systems in place to ensure that they learn and extrapolate risk factors through in-depth review of care provided to patients prior to their deaths, curb and ultimately diminish relative mortality through improved practices, and improve care and safety for the whole organisation.

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Quantitative histologic evaluation reveals different degree of liver atrophy in cachectic and starved dogs.

J Vet Diagn Invest

November 2022

Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Cases of neglect in dogs are among the forensic cases submitted most commonly for postmortem examination. Starvation is a form of primary protein-energy malnutrition in which the availability of food is severely restricted or absent; cachexia is a form of protein-energy malnutrition secondary to progressive metabolic derangement during chronic diseases. Despite both conditions leading to an emaciated appearance of the cadaver, discrimination between the two is crucial in forensic cases.

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Colonic biopsies comprise large portion of pathologists' daily work. Within various pathological entities, there are histological ranges and variations. Unawareness of all of these variabilities might lead to misdiagnosis by an inexperienced pathologist and, accordingly, to mismanagement.

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Eosinophilia during Hantavirus infection: a cohort study.

Infect Dis (Lond)

April 2022

Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Reims, France.

Background: There are emerging eosinophil-related considerations concerning viral infections. The role of eosinophils has poorly been evaluated during Hantavirus infection.

Methods: The aim of this study was to determine the prevalence of eosinophilia (defined as an eosinophil count above 500 cells/mm) during haemorrhagic fever with renal syndrome (HFRS) in a large cohort of patients, and to identify factors associated with eosinophilia.

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Bone and joint infections caused by Clostridium perfringens: a case series.

Eur J Clin Microbiol Infect Dis

October 2021

Department of Internal Medicine and Infectious Diseases, Reims Teaching Hospitals, Avenue du Général Koenig, 51092, Reims, France.

The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused by Clostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients with C.

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The objective of this study was to evaluate the clinical outcomes and safety of clindamycin combination antibiotherapy for the treatment of erythromycin-resistant, lincosamide-susceptible bone and joint infections caused by Staphylococcus spp. Between January 2010 and September 2018, 46 patients with Staphylococcus spp. erythromycin-resistant, lincosamide-susceptible bone and joint infections were treated with clindamycin combination antibiotherapy for 6 to 12 weeks.

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The management of rectal cancer is a major undertaking. There are currently multiple treatment modalities with variable degrees of complications. Radiotherapy (RT) is one of the more frequently used modalities either on its own or more frequently with chemotherapy mostly before the definitive surgery.

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We present a case of a 79-year-old male with a Salmonella enteritidis prosthetic knee joint infection preceded by an episode of profuse diarrhea. The infection was treated with ceftriaxone antibacterial chemotherapy, and an arthroscopic knee joint washout. The initial treatment failed to eradicate the Salmonella infection.

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Background: Short duration of post-amputation antibiotic therapy (2-5 days) is recommended in patients with diabetic foot osteomyelitis after total resection of infected bone tissue.

Objective: To evaluate the long-term effectiveness of short-duration post-amputation antibiotic therapy in diabetic patients with total resection of osteomyelitis assessed by sterile bone bacteriological samples obtained from the resection margin.

Methods: The endpoint was the absence of osteomyelitis relapse at 6 months, defined as recurrence of osteomyelitis with the need for surgical revision and/or new bone antibiotic therapy.

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The number of women studying in medical schools is increasing, and the relative proportion of female consultants in surgical and leadership roles is lagging behind, relatively, and so a new drive for promoting and supporting women in surgery has evolved. A part of this was the creation of the Society of Women in Oral and Maxillofacial Surgery. This short communication gives proceedings of the inaugural conference of SWiMS and discusses the need for greater promotion of women in the speciality (and the profession at large) and how the society has addressed the need for resilience and community in surgical training and beyond.

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Article Synopsis
  • - The study analyzed blood pressure control in 336 pediatric renal transplant patients, revealing a high prevalence of hypertension post-transplant, with 84% affected at discharge and 77% at three years later, despite substantial use of antihypertensive medications.
  • - Younger patients, especially those transplanted before age 5, showed consistently high systolic blood pressure but received less treatment over time, while factors like male sex, higher BMI, and high cyclosporine A levels were linked to elevated blood pressure.
  • - The findings highlight inadequate blood pressure management in this cohort and suggest that specific groups, like young children and older girls, may require targeted monitoring and treatment strategies to improve outcomes.
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