1,017 results match your criteria: "Manchester Royal Eye Hospital[Affiliation]"

Purpose: To report national practices and recent progress in competency-based medical education (CBME) implementation in ophthalmology across European countries.

Methods: A 30-question online survey was emailed to European Union of Medical Specialists (UEMS) ophthalmology section delegates, European Board of Ophthalmology Diploma (EBOD) examiners and presidents of ophthalmology societies affiliated with UEMS/EBO.

Results: A total of 230 ophthalmologists with an average age of 54.

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Objective: This study aims to present and analyze the results of the French cohort in a European Board of Ophthalmology (EBO) survey on cataract surgical training in Europe, highlighting the particularities of French training.

Materials And Methods: A 23-question electronic questionnaire was sent to interns applying for the EBO examination from 2018 to 2022. Responses from French participants were specifically collected and analyzed.

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Introduction: Neovascular age-related macular degeneration is a global public-health concern, associated with a considerable burden to individuals, healthcare systems, and society. The objective of this study was to understand different perspectives on the challenges associated with the clinical management of neovascular age-related macular degeneration, which could elucidate measures to comprehensively improve clinical care and outcomes.

Methods: A survey was carried out of patients with neovascular age-related macular degeneration, their providers, and clinic staff in 77 clinics across 24 countries on six continents, from a diverse range of healthcare systems, settings, and reimbursement models.

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Introduction: In contrast with patients receiving therapy for retinal disease during clinical trials, those treated in routine clinical practice experience various challenges (including administrative, clinic, social, and patient-related factors) that can often result in high patient and clinic burden, and contribute to suboptimal visual outcomes. The objective of this study was to understand the challenges associated with clinical management of diabetic macular edema from the perspectives of patients, healthcare providers, and clinic staff, and identify opportunities to improve eye care for people with diabetes.

Methods: We conducted a survey of patients with diabetic macular edema, providers, and clinic staff in 78 clinics across 24 countries on six continents, representing a diverse range of individuals, healthcare systems, settings, and reimbursement models.

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Purpose: Eye rubbing is considered to play a significant role in the progression of keratoconus and of corneal ectasia following refractive surgery. To our knowledge, no tool performs an objective quantitative evaluation of eye rubbing using a device that is familiar to typical patients. We introduce here an innovative solution for objectively quantifying and preventing eye rubbing.

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Introduction: This study, part of a series, analyses the Swiss cohort from an EBO survey on cataract surgery training in Europe, focusing on Switzerland's unique program. The survey identifies two models: training all residents in surgery, and a "high-volume surgeon" model where only some learn CS post-residency.

Methods: This study analyses the survey results of Swiss participants in the EBO examinations (2018-2022) and compared them with the most important cohorts (Germany, France and Spain).

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Motivation: Genome-wide association studies (GWAS) have been remarkably successful in identifying associations between genetic variants and imaging-derived phenotypes. To date, the main focus of these analyses has been on established, clinically-used imaging features. We sought to investigate if deep learning approaches can detect more nuanced patterns of image variability.

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Background/objectives: Evaluate the mid-term outcomes of the PAUL Glaucoma Implant (PGI) in the management of uveitic glaucoma.

Subjects/methods: This was a single-centre, multi-surgeon, retrospective analysis of 50 consecutive cases of PGI for uveitic glaucoma performed between April 2019 and August 2021. Primary outcomes include: complete and qualified success (IOP ≥5 mmHg to ≤21 mmHg with ≥20% IOP reduction) or failure (IOP exceeding the success criteria, additional glaucoma procedures, no perception of light vision).

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Early versus delayed timing of vitrectomy after open-globe injury.

Cochrane Database Syst Rev

November 2024

Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

Article Synopsis
  • This protocol outlines a Cochrane Review focused on the timing of vitrectomy following open-globe injuries.
  • The main goal is to compare the effects of performing the surgery early versus later on patients' visual outcomes.
  • The review aims to provide evidence that could guide clinical decisions regarding the optimal timing for vitrectomy in such cases.
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A New "Tube-in-tube" Method to Extend Glaucoma Drainage Devices Using Paul Glaucoma Implant.

J Curr Glaucoma Pract

October 2024

Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, England, United Kingdom.

Aim And Background: To describe a novel and uncomplicated technique of elongating the tubing of a glaucoma drainage device (GDD) sourced from a segment of the tube from a Paul® Glaucoma Implant (PGI).

Surgical Technique: Conjunctival and Tenon's peritomy are performed with relaxing incisions to expose the original tube. The original tube is then removed from the anterior chamber, and the original entry site is closed.

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Retinopathy in Mucopolysaccharidoses.

Ophthalmology

November 2024

Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; School of Biological Sciences, Medicine and Health, The University of Manchester, Manchester, United Kingdom. Electronic address:

Purpose: To determine the pattern(s) of onset, variation, and progression of retinopathy in patients with Mucopolysaccharidosis (MPS).

Design: Prospective, longitudinal, observational study.

Participants: Between November 2015 and March 2023, individuals with MPS were recruited from Ophthalmology clinics at the Manchester Royal Eye Hospital, United Kingdom.

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Care pathways for the management of acute ophthalmic conditions have developed and transformed significantly over recent years, owing to a combination of legislative changes, policy implementation and the pressing requirement to redistribute increased demand away from traditional secondary care providers through collaboration with primary care. Following UK healthcare devolution in 1999, each nation has developed and implemented their own strategies for managing the growing demands on acute ophthalmology services. Local commissioning across England has seen Enhanced Service Pathways develop to provide acute eye care by primary care optometrists, with provision and access dependent upon locality.

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Patient preferences for ocular hypertension monitoring: a discrete choice experiment.

BMJ Open Ophthalmol

October 2024

Health Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.

Background/aims: To elicit the preferences and calculate the willingness to pay (WTP) of patients with ocular hypertension (OHT) for eye monitoring services in the UK.

Methods: Patients with OHT aged at least 18 years recruited from four NHS ophthalmology departments were included in the study. Patients' preferences and WTP for an OHT monitoring service in the National Health Service were elicited using a discrete choice experiment (DCE) within a postal survey based on six attributes: (1) how OHT monitoring is organised, (2) monitoring frequency, (3) travel time from home, (4) use of a risk calculator for conversion to glaucoma, (5) risk of developing glaucoma in the next 10 years and (6) cost of monitoring.

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Purpose: To design and build a new disease registry to track the natural history and outcomes of approved gene therapy in patients with inherited retinal diseases (IRDs).

Methods: A core committee of 6 members was convened to oversee the construction of the FIRB! module. A further 11 experts formed a steering committee, which discussed disease classification and variables to form minimum datasets via a consensus approach.

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Purpose: Socioeconomic deprivation is associated with an increased incidence of sight-loss. To inform potential developments in eyecare, General Ophthalmic Service (GOS) sight-testing activity was explored in relation to deprivation for GOS contractors submitting National Health Service (NHS) claims in England.

Methods: Data on NHS sight-test claims for the financial year 2022-2023 were sought from NHS England (NHSE), including number of sight-tests by GOS contractors, their unique Organisation Data Service codes and postcodes and age-bands of patients accessing sight-testing.

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Article Synopsis
  • A pilot study evaluated the safety and effectiveness of the Primary Eyecare Glaucoma Service (PEGS) for low-risk glaucoma patients treated in primary care optometry.
  • Out of 98 patients, 93.8% remained suitable for primary care monitoring, with only 4.9% needing referral back to secondary care, and a high agreement rate of 97.8% was found between primary and secondary care management plans.
  • Patient satisfaction was 100%, optometrists felt confident in their care role, and the service significantly reduced carbon emissions by lowering patient travel distance compared to hospital visits.
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Article Synopsis
  • * Analyzed data from 207 eyes over two years showed no significant differences in visual acuity, intraocular pressure, or glaucoma medication use between the two groups, though more cataracts were noted in optometrist-treated eyes.
  • * Overall, the study concluded that both optometrists and ophthalmologists have similar SLT treatment outcomes, but ophthalmologist-treated eyes had higher medication use and lower rates of subsequent surgery.
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Purpose: The purpose of this study was to examine the direct impact on carbon emissions attributed to the use of fluorinated gases in endothelial keratoplasty (EK) procedures using gas tamponade and to evaluate the respective carbon footprint of different gas delivery systems used in EK procedures.

Methods: In this retrospective, single-center environmental impact study, all corneal procedures using fluorinated gases between January 2021 and January 2024 at the Royal Liverpool University Hospital were reviewed and included. The CO2 equivalent emissions were calculated based on the mass of each fluorinated gas used, following the guidelines of the Intergovernmental Panel on Climate Change.

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Article Synopsis
  • The study examined the incidence and patterns of reactivation in patients with neovascular age-related macular degeneration (nAMD) after successful treatment with anti-VEGF therapy.
  • It included 286 patients, primarily female and receiving aflibercept, with an average of 17.79 injections over approximately 39 months; 32.2% of patients experienced reactivation within the study period.
  • Significant findings showed that a majority (73.9%) of reactivations occurred within three years, and 39.1% were asymptomatic, highlighting the need for ongoing monitoring post-treatment.
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The co-occurrence of genetic variants in the TYR and OCA2 genes confers susceptibility to albinism.

Nat Commun

September 2024

Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Article Synopsis
  • * Researchers analyzed data from over 1,100 individuals with albinism to investigate the combined effects of two specific genetic variants, showing that their presence together significantly increases the likelihood of an albinism diagnosis.
  • * Findings from various cohorts suggest that this combination of variants not only leads to an increased diagnosis rate but also correlates with changes in visual acuity and retinal thickness, paving the way for further research into genetic interactions in Mendelian disorders.
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Temporary Keratoprosthesis and Primary Corneal Graft for Ocular Trauma: A Systematic Review and Meta-Analysis.

Am J Ophthalmol

December 2024

Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust (P.S., R.J.B.), Birmingham, UK; Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine (R.J.B.), Birmingham, UK; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham (R.J.B.), Birmingham, UK. Electronic address:

Article Synopsis
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Putative retina metal/metalloid-binding proteins: molecular functions, biological processes and retina disease associations.

Metallomics

October 2024

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Rm A.3034a Michael-Smith Building, Oxford Road, Manchester M13 9PT, UK.

The mammalian retina contains high amounts of metals/metalloid-selenium. Their dyshomeostases are associated with certain retinal diseases. We carried out this bioinformatics study to identify the relationships between putative retinal metal/selenium binding proteins, their molecular functions, and biological processes.

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Purpose: To evaluate the performance of a disease activity (DA) model developed to detect DA in participants with neovascular age-related macular degeneration (nAMD).

Design: Post hoc analysis.

Participants: Patient dataset from the phase III HAWK and HARRIER (H&H) studies.

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