3 results match your criteria: "Manchester Institute of Biotechnology University of Manchester Manchester UK.[Affiliation]"
Genetic erosion in domesticated barley and a hypothesis of a North African centre of diversity.
Ecol Evol
August 2024
Department of Earth and Environmental Sciences, Manchester Institute of Biotechnology University of Manchester Manchester UK.
Article Synopsis
- Barley is important in the Neolithic transition in West Asia, and new genomics data reveal it was genetically diverse and unique compared to modern types.
- The study used chloroplast genomes and private variant analysis to uncover links between ancient barley and current crops in North Africa and Ethiopia/Eritrea.
- The researchers suggest that a larger North African barley population existed in the past but suffered genetic erosion due to desertification, impacting the diversity seen in modern barley.
The authors explore opportunities, challenges, and strategies to translate and responsibly scale innovative biobased technologies to build more sustainable bioeconomies. The pandemic and other recent disruptions increased exposure to issues of resilience and regional imbalance, highlighting a need for production and consumption regimes centred more on local biobased resources and dispersed production. The authors review potential biobased technology strategies and identify promising and feasible options for the United Kingdom.
View Article and Find Full Text PDFExtracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools, circumventing many of the limitations associated with cell-based therapies. Epigenetic regulation through histone deacetylase (HDAC) inhibition has been shown to increase differentiation capacity. Therefore, this study aimed to investigate the potential of augmenting osteoblast epigenetic functionality using the HDAC inhibitor Trichostatin A (TSA) to enhance the therapeutic efficacy of osteoblast-derived EVs for bone regeneration.
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