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Background: Understanding the genetics underlying the heritable subphenotypes of sickle cell anemia, specific to each population, would be prognostically useful and could inform personalized therapeutics.The objective of this study was to describe the genetic modulators of sickle cell disease in a cohort of pediatric patients followed up in Mayotte.

Methods: This retrospective cohort study analyzed clinical and biological data, collected between January12007 and December 312017, in children younger than 18 years.

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