7,186 results match your criteria: "Malignant Tumors of the Nasal Cavity"

Sinonasal inverted papilloma (SNIP) is less malignant and usually occur in the maxillary sinus. However, cases invading the pterygopalatine fossa are extremely rare. In this article, we describe a rare case of a man in his early 60s who presented with left nasal congestion, headache, epistaxis, and facial numbness.

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The medical data of 10 patients with undifferentiated pleomorphic sarcoma (UPS) from the head and neck at Henan Cancer Hospital from January 2013 to January 2023 were retrospectively analyzed. There were 5 males and 5 females, aged (57.6±13.

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Primary head and neck lymphoid neoplasms(PHNLN) are described as a series of lymphoid system-derived neoplasms which originally arising from head and neck region. Our study is aimed to present a panoramic view of PHNLN among adolescent and young adult(AYA) patients aged from 15 to 39 years-old. The individual patient information was obtained from Surveillance, Epidemiology and End Results(SEER) database.

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Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases.

Endocr Pathol

December 2024

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China.

Epstein-Barr Virus (EBV)-positive neuroendocrine carcinoma (NEC) is a rare neoplasm with limited histopathological and therapeutic data. This report presents 22 cases of EBV-positive NEC, analyzing age distribution, morphology, and immunophenotype. The median patient age was 47 years (range: 27-67 years), with a male-to-female ratio of 17:5.

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[Application of nasal pedicle mucosal flap based on nasal blood supply in reconstruction of nasal skull base defects].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

November 2024

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Key Laboratory of Otolaryngology Major Diseases in Hunan Province, Changsha410008, China.

Article Synopsis
  • The study assessed the effectiveness of nasal pedicle tissue flap techniques for repair of skull base defects in 138 cases from March 2017 to March 2023 at a hospital in China.
  • Out of the patients, 96.4% had successful primary repairs, while 3.6% experienced complications like cerebrospinal fluid leaks.
  • Various flap techniques were utilized based on blood supply sources, with the posterior nasal septal artery being the most common, and complications were managed successfully.
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  • The study analyzes 12 cases of juvenile nasopharyngeal angiofibroma (JNA) in young males treated at a hospital between 2015 and 2020, focusing on the effectiveness of endoscopic plasma resection.
  • Preoperative imaging and selective artery embolization were performed, and patients were followed for at least 30 months to monitor outcomes.
  • Results showed clear vision, minimal bleeding, quick recovery, and no tumor recurrence, suggesting that this technique is a safe and effective treatment for JNA.
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Article Synopsis
  • A study analyzed sinonasal malignancies in Germany using data from the German Center for Cancer Registry, covering 8,332 cases from 2003 to 2015 to address gaps in cancer registries.
  • The findings showed an increase in cancer incidence, particularly among men, with a five-year overall survival rate of 63% for nasal cavity cancers, but lower rates for those in the frontal sinus.
  • The study highlighted the varying survival rates among different tumor types, emphasizing the need for improved early-stage screening due to the moderate to high mortality rates associated with sinonasal cancers, particularly for sinonasal undifferentiated carcinoma and mucosal melanoma.
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This video article aims to describe the surgical technique and effectiveness of a combined endoscopic transnasal and pre-lacrimal recess approach for paramedian V2 schwannoma.

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Seromucinous hamartoma with unique clinical and histopathological features: a case report and review of the literature.

J Med Case Rep

November 2024

Department of anatomical Pathology, Hotel Dieu de France Hospital, Saint Joseph University, Alfred Naccache Boulevard, PO Box: 166830, Ashrafieh, Beirut, Lebanon.

Background: We present this case to highlight the importance of considering seromucinous hamartoma in the differential diagnosis of nasal cavity lesions, particularly due to its rarity and potential for being mistaken for more aggressive pathologies. Seromucinous hamartoma, although benign, can exhibit clinical and histological features that overlap with those of malignant tumors, posing a diagnostic challenge. This case is especially noteworthy due to the unusual presentation of sebaceous differentiation within seromucinous hamartoma, a feature not previously documented in the literature.

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Introduction: Diffuse large B-cell Lymphoma (DLBCL) is a heterogeneous group of malignant tumors with diverse prognoses, histological appearances, and clinical symptoms. While it commonly affects lymphoid tissues, its occurrence in the nasal cavity and paranasal sinuses is rare and poses significant diagnostic challenges.

Case Presentation: The authors present a case of a 53-year-old man with a history of testicular non-Hodgkin lymphoma treated 5 months prior.

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Solitary fibrous tumors (SFTs) are mesenchymal neoplasms associated with the characteristic gene fusion. They frequently occur in extra-thoracic sites and are not uncommon in the head and neck (HN) region. Myxoid SFT is a rare morphological subtype of SFT, the features of which overlap with those of other myxoid-appearing tumors, making the diagnosis challenging.

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Purpose: The purpose of this study was to evaluate the additional value of dynamic contrast-enhanced (DCE) MRI and diffusion weighted MRI (DWI) in differentiation between inflammatory myofibroblastic tumor (IMT) and squamous cell carcinoma (SCC) in the sinonasal cavity.

Methods: Patients with pathologically proven IMT and SCC in the sinonasal region were enrolled in this retrospective study. All participants underwent conventional MRI and dynamic contrast-enhanced MRI, while a subset of them performed DWI.

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Background: Inverted papilloma is a benign epithelial tumour located in the sinonasal tract with a high recurrence rate and a potential of malignant transformation. From 2017, patients with IP were included in our fast-track regime similar to head and neck cancer patients, including follow-up at 2, 6, 12, 18 and 24 months after surgery, then yearly for a total of 5 years.

Aims/objectives: This study aims to compare the recurrence rate and malignant transformation of patients with IP treated at a university centre following the implementation of a fast-track regime including a close follow-up.

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Spindle Cell Neoplasms Unique to the Sinonasal Tract.

Surg Pathol Clin

December 2024

Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 445 Great Circle Road, Office 1959, Nashville, TN 37228, USA.

Article Synopsis
  • - The spindle cell neoplasms encompass three main types: sinonasal tract angiofibroma (STA), glomangiopericytoma (GPC), and biphenotypic sinonasal sarcoma (BSNS), which share similarities in their clinical and biological features.
  • - Sinonasal tract angiofibroma (STA) is characterized by a collagen-rich, vascular stroma often linked to hormonal changes.
  • - Glomangiopericytoma (GPC) has a distinct appearance with a consistent ovular shape and shows Beta-catenin accumulation, while biphenotypic sinonasal sarcoma (BSNS) displays characteristics resembling neural tissue and co-expresses S100 and smooth muscle markers along with
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Sinonasal Adenocarcinomas: An Update.

Surg Pathol Clin

December 2024

Department of Translational Research, Section of Pathology, University of Pisa 56124, Italy. Electronic address:

Among sinonasal malignancies, adenocarcinomas account for the second most common entity after squamous cell carcinoma. They span a wide spectrum of neoplasms with heterogeneous features including intestinal-type adenocarcinoma (ITAC), non-intestinal-type adenocarcinomas (non-ITACs), and salivary-type adenocarcinomas. ITAC basically mirrors the histopathological aspects of gastrointestinal counterparts, showing variable tubulo-papillary, colonic, and mixed patterns with mucin production in 20% to 25% of cases.

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Olfactory Neuroblastoma and Olfactory Carcinoma: A Practical Review.

Surg Pathol Clin

December 2024

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Article Synopsis
  • The sinonasal tract includes two main tumor types with neuroectodermal differentiation: Olfactory neuroblastoma (ONB) and the newly-recognized Olfactory carcinoma (OC).
  • ONB is characterized as a keratin-negative tumor with a lobulated structure, while OC is keratin-positive and often has well-formed glands present.
  • The review aims to clarify the clinical and diagnostic features of ONB and OC, and how they can be differentiated from other similar tumors in the sinonasal area.
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Article Synopsis
  • - A 13-year-old girl diagnosed with SIADH (Syndrome of Inappropriate Antidiuretic Hormone) after restrictive eating had normal initial brain MRIs, later revealing olfactory neuroblastoma (ONB) 2.5 years post-diagnosis.
  • - Initial treatments for SIADH included fluid restriction, which was somewhat effective, but the condition recurred post-surgery for ONB, indicating persistence of SIADH even after successful tumor removal.
  • - The case emphasizes the need for healthcare providers to consider the possibility of ONB when evaluating children with unexplained SIADH, recommending earlier imaging and endoscopy if no clear cause is found.
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Article Synopsis
  • - The study focuses on the mucosal epithelium in the head and neck, where nicotine from tobacco smoke may influence the behavior of head and neck squamous carcinoma (HNSC) cells through nicotinic acetylcholine receptors (nAChRs), particularly CHRNA5.
  • - Various assays (CCK-8, wound healing, Transwell, and clonogenic) were conducted to evaluate the impact of nicotine on cell proliferation, migration, and invasion, revealing that nicotine promotes these processes through CHRNA5.
  • - Results indicated that knocking down CHRNA5 reduces tumor cell activity, suggesting a regulatory interaction with CES1 and linking the CHRNA5 signaling to the MEK/ERK pathway, which
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Article Synopsis
  • The Uninostril Endonasal Transsphenoidal approach preserves nasal anatomy, allowing for normal breathing and fewer nasal complications post-surgery, while providing simplified access and preserving the other nostril for potential use.
  • It is particularly suitable for certain types of pituitary adenomas and focuses on proper patient positioning to facilitate optimal tumor removal and minimize bleeding.
  • However, this technique does face challenges like a limited field of view and potential difficulties in instrument maneuverability, which may necessitate converting to the Bi-nostril approach if complications arise.
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Article Synopsis
  • - The article examines a rare case of ameloblastoma found in a 74-year-old man, impacting the right maxilla, maxillary sinus, and nasal cavity, initially misdiagnosed as squamous cell carcinoma.
  • - A biopsy revealed uncertain origins for the tumor's multiple histologic patterns, leading to a confirmed diagnosis after surgical resection, highlighting challenges in clinical classification based on WHO's 2022 guidelines.
  • - The literature review of 45 similar cases showed that maxillary ameloblastoma often invades crucial structures, with common extensions to the nasal cavity and orbit, and emphasizes the difficulty in differentiating between primary sinonasal and gnathic origins.
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Pediatric non-nasopharyngeal head and neck squamous cell carcinoma: Analysis of the Surveillance, Epidemiology, and End Results (SEER) program with review of the literature.

Int J Pediatr Otorhinolaryngol

November 2024

Louisiana State University Health Sciences Center, Department of Otolaryngology-Head and Neck Surgery, New Orleans, LA, USA; Children's Hospital of New Orleans, Division of Otolaryngology, New Orleans, LA, USA. Electronic address:

Article Synopsis
  • Head and neck squamous cell carcinoma (HNSCC) is rare in pediatric patients compared to adults, where other tumors like lymphomas are more common; the disease's association with the human papillomavirus raises concerns about its prevalence and impact on children's health.
  • This study examined data from the National Cancer Institute’s SEER database to analyze the incidence, characteristics, treatments, and survival rates of pediatric HNSCC cases from 1973 to 2019, identifying 292 cases primarily affecting males and older children.
  • Results showed that nasopharynx is the most common site for HNSCC in children, with a notable overall 5-year survival rate of 83.6%, and the disease tends to be more
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Article Synopsis
  • * Using propensity score matching, the results compared survival outcomes between 96 patients treated with ENI and 53 who were not, revealing significant improvements in overall survival (OS), progression-free survival (PFS), and locoregional relapse-free survival (LRFS) for those receiving ENI.
  • * The study concludes that ENI appears to reduce regional failure rates and should be considered in treatment planning for locally advanced node-negative ENB patients, particularly those classified as
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Endoscopic endonasal extradural posterior clinoidectomy: A key maneuver to access the retrosellar and upper retroclival area.

J Clin Neurosci

November 2024

Department of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Article Synopsis
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Diagnostic Utility of Canine C-Reactive Protein, Haptoglobin, and 25-Hydroxyvitamin-D in Dogs with Nasal Cavity Disease.

Animals (Basel)

October 2024

Ear, Nose and Throat Unit, Small Animal Department, Faculty of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.

Article Synopsis
  • The study examined the diagnostic value of canine C-reactive protein (c-CRP), haptoglobin (HPT), and 25-hydroxyvitamin-D (25(OH)D) in 55 dogs with nasal cavity disease (ND), focusing on differentiating between malignant and benign conditions.
  • Out of the initial dogs, 17 were excluded due to systemic diseases or steroid treatments, resulting in 25 dogs with malignant ND and 30 with benign ND.
  • The findings revealed that while c-CRP levels were higher in ND dogs compared to controls, no significant differences were observed in HPT levels, and lower 25(OH)D levels were noted in malignant cases; overall, the serum markers
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