2,526 results match your criteria: "Malignant Tumors of the Base of Tongue"

A systematic review of the clinicopathological characteristics of oral leiomyomatous hamartoma.

World J Surg Oncol

December 2024

Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India.

Background: Oral leiomyomatous hamartoma (OLH) corresponds to an abnormal, benign and disorganized overgrowth of mature smooth muscle tissue, which can develop in any site where this tissue is found in healthy conditions. The present systematic review aimed to analyze the clinicopathological characteristics of OLH.

Materials And Methods: The protocol of this study was constructed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in the Open Science Framework (OSF): OSF.

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Article Synopsis
  • Trans-oral robotic surgery (TORS) and trans-oral laser microsurgery (TLM) are effective methods for identifying unknown primary cancers in the head and neck area, with a focus on tonsillectomy techniques.
  • A systematic review found that 65% of patients had their primary tumors identified using TORS and TLM, with better results from TLM compared to TORS, especially for HPV-related tumors.
  • Complications were relatively low, with nasogastric/gastrostomy issues occurring in 6% of cases, and hospitalization varied between 1 to over 7 days.
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Objective: The aim of this study was to investigate whether the base of the tongue harbours a transformation zone (TZ), i.e., an initiation site for papillomavirus infection, analogous to that in the uterine cervix by examining the histological structure of Von Ebner's gland ducts in the vallate papillae.

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Purpose: Adenoid cystic carcinoma (AdCC) of the head and neck harbors MYB/MYBL1::NFIB fusions in around 60% of cases, with unfavorable long-term survival due to frequent recurrences and metastases, currently lacking effective targeted therapy. The study aims to identify actionable alterations and to elucidate the molecular underpinnings of MYB/MYBL1::NFIB-negative AdCC using a large targeted RNA sequencing panel.

Methods And Results: We retrospectively searched our MSK-Solid Fusion clinical sequencing database for head and neck AdCC sequenced between 2016 and 2023.

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Malignant Salivary Gland Neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: An Unusual Case with Literature Review.

Head Neck Pathol

November 2024

Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.

Article Synopsis
  • The study discusses challenges in classifying salivary gland malignancies due to their similar features, highlighting the usefulness of molecular phenotyping, particularly through next-generation sequencing (NGS).
  • A case of a young female with a salivary gland tumor at the tongue base was presented, revealing an EWSR1::BEND2 gene fusion through RNA-based NGS, which is a rare finding in this type of cancer.
  • The findings suggest that the EWSR1::BEND2 fusion may play a significant role in the development of salivary gland tumors, indicating that RNA-based NGS is crucial for accurate diagnosis and understanding of this rare malignancy.
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A case report on lingual schwannoma.

S Afr J Surg

October 2024

Division of Otorhinolaryngology, University of Cape Town, South Africa.

Schwannomas are benign tumours of peripheral nerves originating in the nerve sheaths. Only 1% are reported in the oral cavity. We report a 24-year-old female who presented with a 10-year history of a mass at the base of the tongue with associated odynodysphagia, referred otalgia and loss of weight.

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Cavernous Hemangioma of the Tongue Base: A Rare Case.

Cureus

September 2024

Otolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.

Article Synopsis
  • * Cavernous hemangiomas, though rare in locations like the tongue base, pose diagnostic challenges and potential complications such as bleeding, as highlighted by a case involving a Malay man with a year-long history of globus sensation.
  • * Initial imaging suggested a venolymphatic malformation, but after excision, histological analysis confirmed it as a cavernous hemangioma, illustrating the importance of careful diagnosis and surgical management.
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Article Synopsis
  • - The study aimed to assess whether it is possible to protect the structures involved in swallowing and aspiration (DARS) during radiation therapy for head and neck cancer, while still effectively treating the tumors.
  • - Researchers outlined specific target areas and dose limits for DARS in 35 patients, finding that the average dose received by these critical structures varied depending on the type of cancer and the size of the tumor volume.
  • - Results indicated that sparing DARS was more difficult for patients with oropharyngeal cancers compared to laryngopharyngeal cancers, but it was achievable when the tumor volume was less than 150 cc or in patients with no or only one affected lymph node.
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Article Synopsis
  • - MiNENs (mixed neuroendocrine and non-neuroendocrine neoplasms) are rare, aggressive tumors that include both neuroendocrine and non-neuroendocrine components, commonly found in the gastrointestinal tract and associated with a poor prognosis.
  • - A case study of a 69-year-old male with a history of tongue cancer pointed to the presence of a MiNEN in the oropharynx, which was discovered after experiencing odynophagia (painful swallowing). Biopsy revealed features of poorly differentiated neuroendocrine carcinoma.
  • - Following surgery and a successful recovery, the patient has shown no signs of recurrence after one year, marking the first documented case of MiNEN in
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Malignant salivary gland tumors of the tongue: A multicenter REFCOR study.

Int J Cancer

January 2025

Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.

Article Synopsis
  • Salivary carcinomas of minor salivary glands, particularly in the tongue, are rare tumors that may require surgery and/or (chemo-)radiotherapy for treatment.
  • A study involving 103 patients diagnosed between 2009 and 2018 found that the most common types were adenoid cystic and mucoepidermoid carcinomas, with surgery being the primary treatment for most cases.
  • Results indicated that 5-year overall survival was 84.7%, while event-free survival was lower at 38.6%; nonsurgical treatment, alcohol use, and tumor location negatively impacted event-free survival, while nodal positivity was a key factor affecting overall survival.
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Article Synopsis
  • The study focused on assessing the use of ulnar artery flaps for repairing soft tissue defects in the oral and maxillofacial regions, involving 12 patients treated between June 2021 and July 2023.
  • Most patients were male (11 out of 12), with ages averaging 54.8, and the majority had squamous cell carcinoma, leading to various defects in the tongue and buccal areas.
  • Post-surgery, there were no vascular crises, all flaps successfully survived, and most donor site wounds healed well, indicating the effectiveness of this surgical approach.
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[Indications and early experience with transoral robotic surgery].

Magy Onkol

September 2024

Klinikai Központ, Pécsi Tudományegyetem, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Pécs, Hungary.

Recently, organ preservation has gained importance for head and neck malignancies. The negative consequences of the therapies can be reduced without compromising the survival and the quality of life. Accordingly, transoral robotic surgery (TORS) is gaining ground internationally.

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Background: Herein, we evaluated the attributable fraction (AF) of human papillomavirus (HPV)-mediated (HPV+) oropharyngeal carcinomas (OPCs) in Greece over a recent calendar period.

Patients And Methods: ORPHEAS, a retrospective, observational, multicenter, cross-sectional study with prospective recruitment, included adult patients with OPC in 2017-2022, each of them with a high-quality, treatment-naïve tumor specimen. The primary endpoint was the HPV-AF, defined as combined positivity for p16 (p16) overexpression and HPV DNA presence by central laboratory testing, among included patients.

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Article Synopsis
  • * A 65-year-old male patient presented with symptoms like tongue fasciculations and dysarthria, leading to the discovery of a tumor near his vagus nerve through imaging.
  • * Management of skull base paragangliomas varies individually, with the decision made in this case to observe the tumor rather than proceed with immediate treatment.
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Mucoepidermoid carcinoma arising from minor salivary glands at the base of the tongue is rare. Surgical excision of the tumours remains the primary treatment of choice. The prognosis of this tumour depends on optimum clearance of the disease surgically, clinical staging and histopathological grading.

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Background: Common treatments for head and neck cancer (radiation and chemotherapy) can lead to dysphagia; tongue exercise is a common intervention. This study aimed to assess swallow biomechanics and bolus kinematics using a well-established rat model of radiation or chemoradiation treatment to the tongue base, with or without tongue exercise intervention.

Methods: Pre- and post-treatment videofluoroscopy was conducted on 32 male Sprague-Dawley rats treated with radiation/chemoradiation and exercise/no exercise.

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Article Synopsis
  • The study aimed to evaluate the significance of high-risk HPV testing in patients with unknown primary carcinoma but secondary metastasis to the neck, focusing on those who underwent surgical procedures for identification of the primary site.
  • Conducted at a tertiary care center over one year, the study included patients with proven squamous cell carcinoma in the neck and involved various surgical and testing methods, including tonsillectomy and HPV RNA/DNA analysis.
  • Results showed very low positivity rates for p16 (5.56% in tonsils, 0% in tongue, 2.78% in lymph nodes) and undetectable HPV DNA in tissues and blood, suggesting that detailed high-risk HPV analysis may not be crucial in this specific patient population
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FUS::CREM fusion is a distinct primary driver in rare neoplasms of the head and neck and other anatomic sites. Herein, we describe the clinicopathological, imaging, and molecular features of a malignant epithelioid mesenchymal neoplasm harboring FUS::CREM fusion, arising in the tongue of a 46-year-old male. Clinically, the patient presented with a left upper neck mass.

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Purpose: Radiomics is an emerging field that utilizes quantitative features extracted from medical images to predict clinically meaningful outcomes. Validating findings is crucial to assess radiomics applicability. We aimed to validate previously published magnetic resonance imaging (MRI) radiomics models to predict oncological outcomes in oral tongue squamous cell carcinoma (OTSCC).

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