Production of Egg Yolk Antibody (IgY) Against O1: Protective Effect in Mice.

Background: Cholera is an acute intestinal infection caused by (). The development of antibodies against specific may have a therapeutic effect. In the present research, we investigated the protective effect of egg yolk Immunoglobulin (IgY), which was produced by immunizing hens with formaldehyde-killed O1 and subsequently the isolated IgY was orally administrated to the O1 infected mice for evaluation of its immunizing capability.

The use of simple structural parameters of organic compounds to assess their PUF-air partition coefficients.

A novel approach is introduced for the reliable prediction of PUF-air partition coefficients of organic compounds, which can determine the environmental fate of organic compounds during interactions with air, soil, and water. The biggest accessible measured data of PUF-air partition coefficients for 170 chemicals are used to develop and test the novel model. In comparison to available quantitative structure-property relationship (QSPR) methods for the prediction of PUF-air partition coefficients that need complex descriptors, the here used descriptors are simpler.

Preparation of transparent hard GPTMS-AlO thin films on a polycarbonate substrate.

Using polycarbonate (PC) due to its incredible properties as a suitable replacement for inorganic glasses has been increasing. Nevertheless, the low hardness limits its applications in more industries. Hence, it requires to be coated with hard anti-scratch optical coatings to overcome these limitations.

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (FAKHRAVAC®) in healthy adults aged 18-55 years: Randomized, double-blind, placebo-controlled, phase I clinical trial.

Background: The FAKHRAVAC®, an inactivated SARS-CoV-2 vaccine, was assessed for safety and immunogenicity.

Methods And Findings: In this double-blind, placebo-controlled, phase I trial, we randomly assigned 135 healthy adults between 18 and 55 to receive vaccine strengths of 5 or 10 μg/dose or placebo (adjuvant only) in 0-14 or 0-21 schedules. This trial was conducted in a single center in a community setting.

Synthesis of silver nanoparticles for use in conductive inks by chemical reduction method.

In this study, the chemical reduction method was applied to synthesize silver nanoparticles used to prepare conductive inks. The two variables of polyvinylpyrrolidone (PVP)- mole in the 0.01-0.

Investigating the relationship between mechanical properties and residual stress in the laser cladding process of Inconel 625 superalloy.

In the present study, the tensile strength, fracture surface, hardness, and amount of residual stress in Inconel 625 super alloy cladded with direct metal deposition (DLD) process in the states before and after stress relief was studied. Residual stresses on the cladding layer surface were determined via XRD method. According to results, the yield strength of Am sample increased by 10% compared to thecast sample (reference sample).

Foliar co-application of zinc oxide and copper oxide nanoparticles promotes phytochemicals and essential oil production in dragonhead (Dracocephalum moldavica).

Individual nanoparticle application has been documented to promote plant production; however, whether co-application of two nanoparticles (NPs) is more sustainable and significantly promotes plant production is unclear. Herein, foliar co-applications of two NPs or their conventional fertilizer forms on the growth, micronutrient (copper and zinc) enrichment, primary productivity, and essential oil (EO) production in a medicinal annual, dragonhead (Dracocephalum moldavica L.), were investigated.

Cobalt-based metal-organic framework-functionalized graphene oxide modified electrode as a new electrochemical sensing platform for detection of free chlorine in aqueous solution.

This work reports the profit of using a MOF compound for developing a sensitive electrochemical sensor to free chlorine detection in an aqueous solution. Co-MOF and FGO composites were synthesized and combined with the carbon paste (CP) to prepare an efficient electrochemical sensor with high sensing ability. The fabricated Co-MOF and FGO composites were characterized by SEM, EDX, FT-IR, and XRD techniques.

Chemical/photochemical functionalization of polyethylene terephthalate fabric: effects on mechanical properties and bonding to nitrile rubber.

The aim of this work is to compare the effects of chemical and photochemical functionalization on the mechanical properties of PET fabric and its adhesion to nitrile rubber (NBR). The photochemical functionalization was performed by UV irradiation of PET fabric in the presence of glutaric acid peroxide at a temperature of 60 °C for different exposure times (i.e.

Safety and efficacy of the FAKHRAVAC compared with BBIBP-Corv2 against SARS-CoV-2 in adults: a non-inferiority multi-center trial.

Background: We compared Fakhravac and BBIBP-Corv2 vaccines in a phase III trial.

Method: We conducted a multicenter, parallel-group, active-control, non-inferiority clinical trial with pragmatic considerations assessing the safety and efficacy of Fakhravac and BBIBP-Corv2 vaccines. We started with two randomized double-blind arms and added two non-randomized open-label arms (based on participant preference) because of slow recruitment.

Investigating four algorithms for material discrimination in a simulated dual-energy radiography system.

In the present work, a dual-energy X-ray radiography system was simulated using MCNPX code. Then, material discrimination curves for graphite, aluminum, steel, and lead materials were obtained using four algorithms, including log-log, R-T, r-θ, and α-α. The results show that R-T, r-θ, and α-α algorithms have better performance.

Pre-polymerization process simulation, synthesis and investigation the properties of dipicolinic acid molecularly imprinted polymers.

Molecularly imprinted polymers (MIPs) have attracted much attention in recent years due to their structure predictability, recognition specificity, and universal application, as well as robustness, simplicity, and cheapness. In this study, firstly, the pre-polymerization process of molecularly imprinted polymer of dipicolinic acid (DPA) was simulated by molecular dynamics. Then, the appropriate functional monomer molecule for printing was selected and its intermolecular bond with the DPA molecule was evaluated.

Bacterial cellulose-based composites as vehicles for dermal and transdermal drug delivery: A review.

In recent years, a significant amount of drugs have been taken orally, which are not as effective as desired. To solve this problem, bacterial cellulose-based dermal/transdermal drug delivery systems (BC-DDSs) with unique properties such as cell compatibility, hemocompatibility, tunable mechanical properties, and the ability to encapsulate various therapeutic agents with the controlled release have been introduced. A BC-dermal/transdermal DDS reduces first-pass metabolism and systematic side effects while improving patient compliance and dosage effectiveness by controlling drug release through the skin.

Experimental comparison between NbO- and TiO-based photoconductive and photogating GFET UV detector.

In the present study, by adding graphene to a photoconductive photodetector with a niobium pentoxide (NbO) absorber layer and exploiting the photogating effect, the responsivity of the photodetector is significantly improved. In this photodetector, the NbO layer detects the light, and the graphene improves the responsivity based on the photogating effect. The photocurrent and the percentage ratio of the photocurrent to dark current of the NbO photogating photodetector are compared with those of the corresponding photoconductive photodetector.

Comprehensive review on biosynthesis of hyaluronic acid with different molecular weights and its biomedical applications.

Hyaluronic acid (HA), an anionic and nonsulfated glycosaminoglycan, is the main structural component of various tissues and plays an important role in various biological processes. Given the promising properties of HA, such as high cellular compatibility, moisture retention, antiaging, proper interaction with cells, and CD44 targeting, HA can be widely used extensively in drug delivery, tissue engineering, wound healing, and cancer therapy. HA can obtain from animal tissues and microbial fermentation, but its applications depend on its molecular weight.

The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats.

In everyday life, electrical devices are the primary sources of extremely low-frequency electromagnetic fields (ELF-EMF), and the human body may be a great conductor of these fields. We chose alpha band power, especially at 10 Hz frequency, due to its prior beneficial role in memory. The purpose was to clarify whether there is a relationship between ELF-EMF exposure and cognitive deficits in rats, clinical signs, behavioral analysis, and the impact of ELF-EMF during different times of exposure on neuroplasticity via the expression of BDNF.

Effects of 2.45 GHz Non-Ionizing Radiation on Anxiety-Like Behavior, Gene Expression, and Corticosterone Level in Male Rats.

The effects of short-term and long-term exposures to 2.45 GHz radiofrequency electromagnetic radiation (RF-EMR) on anxiety-like behavior, corticosterone level, and gene expression were investigated. The goal of this study was to explore the effect of electromagnetic fields of 2.

The Effect of 2.45 GHz Electromagnetic Fields on Fear Memory Extinction in Male Rats.

Fear memories are influenced by psychological and environmental variables. We evaluated the effect of 2.45 GHz microwave radiation on rats' fear learning and memory ability to determine the potential risks.

The Zebrafish Model as a New Discovery Path for Medicinal Plants in the Treatment of Parkinson's Disease.

Parkinson's disease (PD) is one of the most frequent degenerative central nervous system disorders affecting older adults. Dopaminergic neuron failure in the substantia nigra is a pathological sign connected with the motor shortfall of PD. Due to their low teratogenic and adverse effect potential, medicinal herbs have emerged as a promising therapy option for preventing and curing PD and other neurodegenerative disorders.

αSiC - βSiC - graphene composites.

In this study, the mechanical properties of the pressureless sintered samples of α-SiC based composite containing 0-3 wt.% graphene and 0-15 wt.% nano β-SiC were investigated.

Addressing global food insecurity: Soil-applied zinc oxide nanoparticles promote yield attributes and seed nutrient quality in Glycine max L.

Consumed globally, oilseeds serve as a major source of proteins and oils in human and animal nutrition, supporting global food security. Zinc (Zn) is an essential micronutrient critical for oil and protein synthesis in plants. In this study, we synthesized three distinct sized zinc oxide nanoparticles (nZnO: 38 nm = S [small], 59 nm = M [medium], and > 500 nm = L [large], and assessed the potential effects of varied particle sizes and concentrations (0, 50, 100, 200, and 500 mg/kg-soil) on seed yield attributes, nutrient quality and oil and protein yield in soybean (Glycine max L.

Influence of functional groups in chemical reactivity and optoelectronic properties of novel glycidyl nitrate copolymers (GNCOP): a DFT study.

Introduction: Nowadays, propulsion materials are receiving increased attention as an important component in electric motors. So, awareness of their chemical reactivity and geometric and electronic structures can help to make materials with higher quality and efficiency. In this study, we have proposed novel glycidyl nitrate copolymers (GNCOPs) and meta-substituted derivatives as propulsion materials.

Exploring the experience of developing COVID-19 vaccines in Iran.

Widespread public vaccination is one of the effective mechanisms to ensure the health and prevent deaths in societies. The coronavirus disease 2019 (COVID-19) vaccine is a stark instance in this regard. Vaccine development is a complex process requiring firm-level capabilities, various infrastructures, long-term planning, and stable and efficient policies.