371 results match your criteria: "Malcom Randall VA Medical Center[Affiliation]"
Plast Surg (Oakv)
January 2024
Surgical Services, Plastic Surgery Section, Malcom Randall VA Medical Center, Gainesville, FL, USA.
Both open and endoscopic methods of carpal tunnel release are accepted treatments for carpal tunnel syndrome. The objective was to determine the endoscopic to open conversion rate of all carpal tunnel surgeries. We evaluated potential predictive factors for an increased rate of conversion.
View Article and Find Full Text PDFGait Posture
October 2024
Department of Applied Physiology & Kinesiology, University of Florida, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, USA. Electronic address:
Background: Older adults are less stable and walk slower than younger adults, both of which are associated with higher fall risk. Older adults use ankle musculature less and rely more on hip contributions for forward propulsion than younger adults, which has been suggested to be a protective walking strategy to increase stability. However, whether distal-to-proximal redistribution of propulsion and dynamic margin of stability are related has not been determined.
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Pheochromocytomas (PCCs) are tumors arising from chromaffin cells in the adrenal medulla, and paragangliomas (PGLs) are tumors derived from extra-adrenal sympathetic or parasympathetic paraganglia; these tumors are collectively referred to as PPGL cancer. Treatment for PPGL primarily involves surgical removal of the tumor, and only limited options are available for treatment of the disease once it becomes metastatic. Human carriers of the heterozygous mutations in the succinate dehydrogenase subunit B () gene are susceptible to the development of PPGL.
View Article and Find Full Text PDFJ Appl Biomech
December 2024
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Balance training paradigms have been shown to effectively reduce fall risk. Visual feedback is an important sensory mechanism for regulating postural control, promoting visual perturbations for balance training paradigms. Stroboscopic goggles, which oscillate from transparent to opaque, are a form of visual perturbation, but their effect on standing balance has not been assessed.
View Article and Find Full Text PDFBest Pract Res Clin Endocrinol Metab
December 2024
Department of Medicine, Division of Endocrinology & Metabolism, Malcom Randall VA Medical Center, University of Florida, Gainesville, FL, USA. Electronic address:
The complexity of omes - the key cellular ensembles (genome and epigenome, transcriptome, proteome, and metabolome) - is becoming increasingly understood in terms of big-data analysis, the omics. Amongst these, proteomics provides a global description of quantitative and qualitative alterations of protein expression (or protein abundance in body fluids) in response to physiologic or pathologic processes while metabolomics offers a functional portrait of the physiological state by quantifying metabolite abundances in biological samples. Here, we summarize how different techniques of proteomic and metabolic analysis can be used to define key biochemical characteristics of pheochromocytomas/paragangliomas (PPGL).
View Article and Find Full Text PDFPrim Care Diabetes
October 2024
Center for Drug Evaluation and Safety, Department of Pharmaceutical Evaluation and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Emory Global Diabetes Research Center of Woodruff Health Sciences Center, Emory University, Atlanta, GA, USA. Electronic address:
Anesth Analg
July 2024
Geriatric Research Education and Clinical Center (GRECC), Malcom Randall VA Medical Center, Gainesville, Florida.
Background: Racial disparities exist in access to health care and management of multiple health conditions including chronic pain; however, racial disparities in pre- and postoperative pain management in lower extremity amputation are not well-studied. Our objective was to examine the association between different racial and ethnic groups and prescription opioid and other analgesics use before and after lower extremity amputation. We hypothesize prescription opioid and other analgesic use among Black, Hispanic, and Native American US Medicare beneficiaries undergoing lower extremity amputations will be lower compared to White US Medicare beneficiaries.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
September 2024
Institute on Aging, University of Florida College of Medicine, Gainesville, Florida, USA.
Background: Chat Generative Pre-trained Transformer (ChatGPT) and other ChatBots have emerged as tools for interacting with information in manners resembling natural human speech. Consequently, the technology is used across various disciplines, including business, education, and even in biomedical sciences. There is a need to better understand how ChatGPT can be used to advance gerontology research.
View Article and Find Full Text PDFRes Sq
June 2024
Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.
Pilot Feasibility Stud
June 2024
Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Background: Several changes occur in the central nervous system with increasing age that contribute toward declines in mobility. Neurorehabilitation has proven effective in improving motor function though achieving sustained behavioral and neuroplastic adaptations is more challenging. While effective, rehabilitation usually follows adverse health outcomes, such as injurious falls.
View Article and Find Full Text PDFExp Brain Res
July 2024
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.
Background: Multiple sclerosis is a neurodegenerative disease that damages the myelin sheath within the central nervous system. Axonal demyelination, particularly in the corpus callosum, impacts communication between the brain's hemispheres in persons with multiple sclerosis (PwMS). Changes in interhemispheric communication may impair gait coordination which is modulated by communication across the corpus callosum to excite and inhibit specific muscle groups.
View Article and Find Full Text PDFbioRxiv
May 2024
Department of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.
Older adults exhibit larger individual differences in walking ability and cognitive function than young adults. Characterizing intrinsic brain connectivity differences in older adults across a wide walking performance spectrum may provide insight into the mechanisms of functional decline in some older adults and resilience in others. Thus, the objectives of this study were to: (1) determine whether young adults and high- and low-functioning older adults show group differences in brain network segregation, and (2) determine whether network segregation is associated with working memory and walking function in these groups.
View Article and Find Full Text PDFFront Aging Neurosci
May 2024
Department of Neurology, University of Florida, Gainesville, FL, United States.
Introduction: Walking in complex environments increases the cognitive demand of locomotor control; however, our understanding of the neural mechanisms contributing to walking on uneven terrain is limited. We used a novel method for altering terrain unevenness on a treadmill to investigate the association between terrain unevenness and cortical activity in the prefrontal cortex, a region known to be involved in various cognitive functions.
Methods: Prefrontal cortical activity was measured with functional near infrared spectroscopy while participants walked on a novel custom-made terrain treadmill surface across four different terrains: flat, low, medium, and high levels of unevenness.
JCI Insight
April 2024
Department of Applied Physiology and Kinesiology and.
JAMA Intern Med
June 2024
Geriatric Research Education and Clinical Center, Malcom Randall VA Medical Center, Gainesville, Florida.
J Neurophysiol
May 2024
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom.
The neural pathways that contribute to force production in humans are currently poorly understood, as the relative roles of the corticospinal tract and brainstem pathways, such as the reticulospinal tract (RST), vary substantially across species. Using functional magnetic resonance imaging (fMRI), we aimed to measure activation in the pontine reticular nuclei (PRN) during different submaximal handgrip contractions to determine the potential role of the PRN in force modulation. Thirteen neurologically intact participants (age: 28 ± 6 yr) performed unilateral handgrip contractions at 25%, 50%, 75% of maximum voluntary contraction during brain scans.
View Article and Find Full Text PDFSci Rep
March 2024
Department of Pediatrics, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610-0296, USA.
Neonatal Encephalopathy (NE) is a major cause of lifelong disability and neurological complications in affected infants. Identifying novel diagnostic biomarkers in this population may assist in predicting MRI injury and differentiate neonates with NE from those with low-cord pH or healthy neonates and may help clinicians make real-time decisions. To compare the microRNA (miRNA) profiles between neonates with NE, healthy controls, and neonates with low cord pH.
View Article and Find Full Text PDFExp Gerontol
May 2024
Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL, USA; Department of Neurology, University of Florida, Gainesville, FL, USA.
Walking performance and cognitive function demonstrate strong associations in older adults, with both declining with advancing age. Walking requires the use of cognitive resources, particularly in complex environments like stepping over obstacles. A commonly implemented approach for measuring the cognitive control of walking is a dual-task walking assessment, in which walking is combined with a second task.
View Article and Find Full Text PDFNeurology
April 2024
From the Neurology Service and the Brain Rehabilitation Research Center, Malcom Randall VA Medical Center; Department of Neurology, University of Florida College of Medicine, Gainesville, FL.
Molecules
March 2024
Center for Neurotrauma, MultiOmics and Biomarkers (CNMB), Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10-100 nucleotides in length. Their targets, often with specificity and high affinity, range from ions and small molecules to proteins and other biological molecules as well as larger systems, including cells, tissues, and animals. Aptamers often rival conventional antibodies with improved performance, due to aptamers' unique biophysical and biochemical properties, including small size, synthetic accessibility, facile modification, low production cost, and low immunogenicity.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
April 2024
Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA 30310-1458, (USA). Department of Emergency Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.
Pathological hyperphosphorylation and aggregation of microtubule-associated Tau protein contribute to Alzheimer's Disease (AD) and other related tauopathies. Currently, no cure exists for Alzheimer's Disease. Aptamers offer significant potential as next-generation therapeutics in biotechnology and the treatment of neurological disorders.
View Article and Find Full Text PDFPerfusion
February 2024
Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, Florida, USA.
Eur J Clin Invest
May 2024
Department of Physiological Sciences, University of Florida, Gainesville, Florida, USA.
J Am Med Inform Assoc
April 2024
Cardiology Section, Medical Service, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, United States.
Objectives: We conducted an implementation planning process during the pilot phase of a pragmatic trial, which tests an intervention guided by artificial intelligence (AI) analytics sourced from noninvasive monitoring data in heart failure patients (LINK-HF2).
Materials And Methods: A mixed-method analysis was conducted at 2 pilot sites. Interviews were conducted with 12 of 27 enrolled patients and with 13 participating clinicians.
World J Gastroenterol
January 2024
Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida Shands Children's Hospital, Gainesville, FL 32608, United States.
Background: Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous system. Calcium-sensing receptor (CaSR) inhibits both actions. The latter has been well documented but not .
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