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Objective: To elucidate the neural mechanisms of depression.

Background: Despite extensive study, the neurophysiology of the brain's state(s) corresponding to depression remains uncertain.

Methods: HMPAO single photon emission computed tomographic (SPECT) scans were obtained from eight adults diagnosed with major depression resistant to medication (average age 51 years; 4 men) before and immediately after 10 days of 20 Hz repetitive transcranial magnetic stimulation (rTMS) (2000 stimuli/daily 30' treatment).

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