Computational Elucidation of Hub Genes and Pathways Correlated with the Development of 5-Fluorouracil Resistance in HCT 116 Colorectal Carcinoma Cell Line.

Colorectal cancer (CRC) is the third most deadly cancer diagnosed in both men and women. 5-Fluorouracil (5-FU) treatment frequently causes the CRC cells to become chemoresistance, which has a negative impact on prognosis. Using bioinformatic techniques, this work describes important genes and biological pathways linked to 5-FU resistance in CRC cells.

Development and Validation of Rabies Health Education Module (RaHEM) for Dog Owners in Kelantan, Malaysia: An ADDIE Model.

Background: Rabies is a preventable yet deadly public health threat. Despite the availability of effective vaccines for both humans and animals, the persistence of rabies-related fatalities underscores the need for enhanced public education strategies. This study aimed to develop and validate a Rabies Health Education Module delivered via a Massive Open Online Course, targeting adult dog owners in Kelantan, Malaysia.

A comprehensive review of factors affecting growth and secondary metabolites in hydroponically grown medicinal plants.

Optimizing environmental factors can significantly increase the growth and secondary metabolite synthesis of hydroponically grown medicinal plants. This approach can help increase the quality and quantity of pharmacologically important metabolites to enhance therapeutic needs. Medicinal plants are key therapeutic sources for treating various ailments.

Key informants' views on the benefits, planning and implementation of workplace oral health promotion programme.

This study aimed to explore key informants' views on the potential benefits of workplace oral health promotion (WOHP) among the aged care workforce and identified factors associated with the planning and implementation of such activities. The study interviewed members of key organizations associated with the aged care workforce, including oral health and health professionals, government and non-governmental organizations, aged care providers, unions and other worker support organizations in semi-structured interviews. Interviews were audio-recorded, transcribed verbatim and analysed thematically.

Review of the potential of bioactive compounds in seaweed to reduce histamine formation in fish and fish products.

The formation of histamine in food is influenced by temperature, and histamine growth can be inhibited by maintaining a cold chain. However, simply relying on temperature control is insufficient, as certain bacteria can produce the enzyme histidine decarboxylase even at temperatures below 5°C. To address this issue, various methods, such as modified atmosphere packaging, high hydrostatic pressure, and irradiation, have been developed to control histamine in fishery products.

Water impact analysis due to coal-electricity generation using the life cycle assessment method: a case study in Malaysia.

Coal power plants adversely impact air pollution, but they also pose a risk to our water sources. Discharge wastewater from power plants may degrade the quality of nearby water bodies. This study evaluates the potential water-related environmental impacts of electricity generation at an ultra-supercritical coal power plant in Malaysia using the life cycle assessment method.

Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, activity and computational studies.

Background: Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

Methods: Five Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

Impaired Resting State Functional Connectivity in CADASIL Mutant Mice.

Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most prevalent monogenic inherited cause of cerebral small-vessel disease. Despite its prevalence, there is currently no proven therapy to prevent or reverse the progression of the disease. This study aimed to characterize the functional integrity of long white matter tracts in CADASIL transgenic mice, both with and without focal white matter lesions in the corpus callosum added on, utilizing optical resting-state functional connectivity imaging alongside behavioral examinations.

Microlearning beyond boundaries: A systematic review and a novel framework for improving learning outcomes.

Microlearning has become increasingly popular not only in education sector but also in corporate sector in recent years. However, its definition and didactics conceptualization, integration into instruction design, and effects on learning outcomes remain largely underexplored in terms of synthesized findings. Consequently, challenges persist in clarifying microlearning definition, and didactics, and designing effective microlearning instruction to yield improved learning outcomes.

The use of cannabidiol as adjunctive therapy in adult patients with drug-resistant epilepsy: a systematic review and meta-analysis.

Background: Highly purified cannabidiol (CBD), recently approved for various neurological disorders, is explored as a potential therapeutic avenue for drug-resistant epilepsy (DRE) among adult people with epilepsy (PWE) in this systematic review and meta-analysis.

Objectives: To conduct an extensive literature review and meta-analysis of CBD use for DRE in adult PWE.

Design: Systematic review and meta-analysis.

Local envenomation by green pit viper complicated with airway obstruction.

Snake-related injury (SRI) is one of the most common medical emergencies encountered in tropical countries such as Malaysia. The majority of snake bites are nonvenomous, while the less common venomous snakebite can cause major disability or even death. There are 16 pit viper species documented in Malaysia which can be categorized based on their habitat.

CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation.

Introduction: Owing to its high prevalence, colossal potential of chemoresistance, metastasis, and relapse, breast cancer (BC) is the second leading cause of cancer-related fatalities in women. Several treatments (eg, chemotherapy, surgery, radiations, hormonal therapy, etc.) are conventionally prescribed for the treatment of BC; however, these are associated with serious systemic aftermaths.

Therapeutic Dilemma of a Juxtapapillary Retinal Capillary Hemangioma.

A juxtapapillary retinal capillary hemangioma (JRCH) is a rare vascular hamartoma located on the optic nerve head or adjacent region. While often associated with von Hippel-Lindau (VHL) disease, JRCHs can also occur as an isolated condition, presenting unique therapeutic challenges and risks of visual impairment. We report a case of a 50-year-old Malay gentleman with diabetes mellitus who presented with a non-progressive superior visual field defect in his left eye for three months.

: identification and characterization of plant-conserved microRNA in Rafflesiaceae.

Rafflesiaceae is a family of endangered plants whose members are solely parasitic to the tropical grape vine (Vitaceae). Currently, the genetics of their crosstalk with the host remains unexplored. In this study, we use homology-based approaches to characterize micro-RNAs (miRNAs) expressed by and from published omics data.

Attribution theory of poverty and beliefs about charity in Malaysia: an inter-ethnic comparison.

Introduction: Malaysia as an ethnically diverse country has a history of interethnic inequality and poverty which led to the development of different views about the existence of poverty. Among these ethnic groups, some sympathize with the poor and help them through different charity organizations. However, these charity organizations are mostly unaware of the target donors that can aid their charity funds.

Effects of music training on executive functions in preschool children aged 3-6 years: systematic review and meta-analysis.

Background: Executive functions is a crucial ability in the early development of preschool children. While numerous studies have found that music training has a favorable effect on children's executive functions, there is a lack of a consistent perspective on this topic, particularly with regard to the dose-response relationship.

Methods: Systematic searches were conducted of Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure.

Pre-clinical acute oral toxicity and subacute neurotoxicity risk assessments on sprague dawley rats treated with single dose or repeated doses of flavonoid-enriched fraction extracted from leaves.

possesses promising flavonoid secondary metabolites. However, translation of these compounds into clinical practice for neurological disease treatment is halted as the toxicity and safety profile of the plant extracts are yet to be determined. This study was conducted to assess the acute oral toxicity and subacute neurotoxicity that could be imposed by the flavonoid-enriched fraction (FEF) extracted from leaves, by strictly following the procedures set in Organization for Economic Co-operation and Development (OECD) Guidelines No.

Highly efficient removal of per- and polyfluoroalkyl substances by extrusion-regenerated aminated polyurethane sponges.

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic compounds widely detected in the environments. Due to their chemical stability, physical adsorption has emerged as one of the most promising techniques for remediating PFAS-containing wastewater, while some newly synthesized functional absorbents in powder form suffer from separation issues. Inspired by mussel biology, we have successfully synthesized a porous spongy absorbent termed aminated polyurethane (PU-PDA-PANI) with over 99.

Risk of stroke associated with proton pump inhibitor use among individuals with and without pre-existing cardiovascular diseases: a systematic review and meta-analysis.

Background: Proton pump inhibitors (PPIs) are commonly used for managing gastroesophageal disorders but concerns about their potential association with increased stroke risk have emerged, especially among patients with pre-existing cardiovascular conditions such as acute coronary syndrome (ACS). This systematic review and meta-analysis aim to assess the risk of stroke associated with PPI use, stratified by the presence or absence of pre-existing CVD.

Methods: This review was conducted following the PRISMA guidelines and included studies up to March 2024 from PubMed, Embase, and Web of Science.

Cannabis consumption and risk of asthma: a systematic review and meta-analysis.

Background: Cannabis is the third most widely used psychoactive substance globally, and its consumption has been increasing, particularly with the growing trend of legalization for medicinal and recreational use. Recent studies have raised concerns about the potential impact of cannabis on respiratory health, specifically the risk of asthma, a significant public health concern. This systematic review aimed to consolidate research on the association between cannabis use and the risk of asthma.

Inpatient versus outpatient diagnosis of heart failure across the spectrum of ejection fraction: a population cohort study.

Background: Early heart failure (HF) diagnosis is crucial to ensure that optimal guideline-directed medical therapy (GDMT) is administered to reduce morbidity and mortality. Limited access to echocardiography could lead to a later diagnosis for patients, for example, during an HF hospitalisation (hHF). This study aimed to compare the incidence and outcomes of inpatient versus outpatient diagnosis of HF.

Epidemiological analysis of reported acute glyphosate poisoning in Malaysia: identifying risk factors and high-risk groups (2006-2023).

Objective: Glyphosate is widely used in Malaysian agriculture but poses a significant under-reported public health concern due to poisoning. This paper aims to study the epidemiology of glyphosate poisoning in Malaysia, assessing severity, identifying risk factors, and high-risk groups.

Setting: All glyphosate-related data of the Malaysia National Poison Centre from 2006 to 2023.

Latest clinical frontiers related to autism diagnostic strategies.

The diagnosis of autism is currently based on the developmental history, direct observation of behavior, and reported symptoms, supplemented by rating scales/interviews/structured observational evaluations-which is influenced by the clinician's knowledge and experience-with no established diagnostic biomarkers. A growing body of research has been conducted over the past decades to improve diagnostic accuracy. Here, we provide an overview of the current diagnostic assessment process as well as of recent and ongoing developments to support diagnosis in terms of genetic evaluation, telemedicine, digital technologies, use of machine learning/artificial intelligence, and research on candidate diagnostic biomarkers.

Biolubricants from waste cooking oil: A review of extraction technologies, conversion techniques, and performance enhancement using natural antioxidants.

Effective management of agricultural and industrial by-products is essential for promoting circular economic practices and enhancing environmental sustainability. Agri-food wastes and waste cooking oil (WCO) represent two abundant residual streams with significant potential for sustainable biolubricant production. Valorizing biomass and WCO aligns with Sustainable Development Goal (SDG) 7, as it improves energy efficiency through enhanced lubricant performance and reduced energy loss.