1,223 results match your criteria: "Malakoplakia"

Recurrent bladder malakoplakia: A rare bladder lesion mimicking malignancy.

Bladder (San Franc)

November 2024

Department of Pathology and Laboratory Medicine, Brantford General Hospital, Brantford, Ontario N3R 1G9, Canada.

Background: Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract with the urinary bladder being the most frequently affected site. It is characterized by histiocytes containing distinct basophilic calcified inclusions called Michaelis-Gutmann bodies. It is believed to result from abnormally functioning macrophages, with inclusions representing calcifications around incompletely digested bacteria.

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Pulmonary malakoplakia due to Prescottella (Rhodococcus) soli in a renal transplant recipient: First reported case.

Eur J Microbiol Immunol (Bp)

December 2024

1Department of Microbiology, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.

Prescottella (Rhodococcus) soli is a soil-dwelling organism not previously thought to be pathogenic in humans. We discuss the case of a 78-year-old male renal transplant recipient presenting with respiratory symptoms and multiple pulmonary nodules, found to be pulmonary malakoplakia secondary to infection with Prescottella (Rhodococcus) soli. Treatment was commenced with vancomycin, meropenem and azithromycin for an induction period of two weeks and continued with indefinite oral moxifloxacin and azithromycin with significant clinical improvement.

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A rare case of prostatic malakoplakia with multidrug-resistant Escherichia coli: a case report.

BMC Infect Dis

October 2024

Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Prostatic malakoplakia is an uncommon chronic inflammatory disorder, tumor-like but non-cancerous, the diagnosis of which pivots crucially on the identification of characteristic Michaelis-Gutmann bodies within the pathological tissue. We hereby present an inaugural case report of prostatic malakoplakia concurrent with sepsis caused by multidrug-resistant Escherichia coli, verified through blood culture and metagenomic next-generation sequencing (mNGS). The pathogenesis might be associated with infections by Escherichia coli, immune system irregularities, or lysosomal dysfunction.

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[Malacoplakia of liver: report of a case].

Zhonghua Bing Li Xue Za Zhi

November 2024

Department of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

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Malakoplakia is a rare inflammatory granulomatous disease that can produce a tumor-like appearance in nearly any organ system. Imaging findings of malakoplakia overlap with malignancy and tissue sampling are typically required for definitive diagnosis. We present a case of a 66-year-old woman with a previous history of liver adenocarcinoma status post resection that subsequently developed an intensely FDG-avid retroperitoneal mass on surveillance imaging.

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Article Synopsis
  • - Malakoplakia is a rare inflammatory disease marked by specific cells and is particularly elusive when affecting the kidneys, as shown in a case involving a patient diagnosed in infancy.
  • - After 17 years, the patient experienced kidney issues leading to a diagnosis of focal segmental glomerulosclerosis (FSGS), but typical malakoplakia markers were not found in kidney biopsy samples.
  • - This case highlights that kidney damage from malakoplakia can evolve into FSGS and demonstrates how the disease can change over time, providing valuable insights into the long-term prognosis of renal parenchymal malakoplakia.
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Malakoplakia, a rare granulomatous inflammatory condition, typically manifests in the genitourinary system. Its occurrence in the gallbladder is exceptionally uncommon, posing significant diagnostic challenges. A 68-year-old male presented with recurrent epigastric pain, and a suspicious gallbladder mass was found on imaging.

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Multiparameter MRI features of prostatic malakoplakia.

Br J Radiol

January 2025

Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Article Synopsis
  • This study examined the imaging features of prostatic malakoplakia in 11 patients, all confirmed through pathology, with a median age of 62 years.
  • Results showed that lesions typically had high PI-RADS scores (4 or 5), involved the peripheral zone, and displayed various distribution patterns without infiltration into surrounding tissues.
  • Key imaging characteristics included moderate hypointensity on T2-weighted images, slightly higher signal on T1-weighted images, and specific enhancement patterns, helping to distinguish prostatic malakoplakia from cancer.
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Malakoplakia in a Transplanted Liver.

ACG Case Rep J

September 2024

Department of Gastroenterology and Hepatology, Cleveland Clinic, Weston, FL.

Article Synopsis
  • Malakoplakia is a rare condition that typically affects the urinary bladder, but there have been only 8 reported cases involving the liver, with this being the first in a transplanted liver.
  • A 63-year-old man with a history of liver transplantation presented with fever, chills, and abdominal pain, leading to imaging that revealed persistent microabscesses in his liver despite antibiotic treatment.
  • Surgical intervention involved a hepatectomy to remove the affected segment, and the examination of tissue samples confirmed the presence of malakoplakia.
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  • * A case study is presented involving a 61-year-old male who developed quadriparesis and gait issues after liver transplant and antibiotic treatment for Escherichia coli, leading to suspicion of spinal cord malakoplakia.
  • * Malakoplakia can mimic malignant tumors in its clinical and radiologic presentation, posing challenges in diagnosis and treatment due to its spinal cord location, highlighting the need for differential diagnosis for intramedullary masses.
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Article Synopsis
  • * The condition commonly affects the urinary tract and gastrointestinal tract, particularly the colon and rectum, and is seldom seen in children.
  • * Treatment involves using specific antibiotics that target macrophages and cholinergic agents to enhance the immune response, with a reported case in a pediatric leukemia patient highlighting its rarity.
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Article Synopsis
  • - Malakoplakia is a rare type of inflammation mainly seen in the urinary bladders of dogs, with only one previous case reported in the colon.
  • - A 5-month-old spayed female French Bulldog was diagnosed with colonic malakoplakia after showing symptoms like chronic diarrhea and blood in feces, which did not improve with initial treatments.
  • - The dog showed significant recovery after 8 months of treatment with enrofloxacin, with noticeable progress after just 2 months.
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Article Synopsis
  • - A 61-year-old man experienced progressive left-sided weakness, leading to an MRI that revealed a 1.3-cm enhancing mass in the cervical spinal cord, raising concerns for malignancy.
  • - An 18F-FDG PET/CT scan showed a hypermetabolic mass but no signs of cancer or metastasis.
  • - After a subtotal excision of the mass and histopathological examination, it was determined to be malakoplakia, highlighting the critical role of accurate diagnostic procedures.
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Malakoplakia Involving the Maxilla: A Case Report and a Review of the Literature.

Head Neck Pathol

June 2024

Division of Dental and Oral Medicine, New York-Presbyterian/Queens, Flushing, New York, USA.

Article Synopsis
  • Malakoplakia is a rare inflammatory disorder mainly seen in immunocompromised patients, characterized by an inability of macrophages to effectively kill bacteria.
  • Although it usually occurs in the genitourinary and gastrointestinal regions, this report highlights a rare case where malakoplakia affected the maxilla and maxillary alveolar ridge mucosa, marking a unique instance of oral cavity involvement.
  • Diagnostic stains revealed specific patterns indicating malakoplakia without evidence of microbial infection, emphasizing the need for clinicians and pathologists to consider this condition when evaluating lesions in immunosuppressed patients.
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Article Synopsis
  • Malakoplakia is a rare disease that causes chronic inflammation, usually in the urogenital organs, and can be diagnosed by looking for special bodies called Michaelis-Gutmann bodies.
  • In this case, a patient was wrongly diagnosed with advanced ovarian cancer but actually had malakoplakia along with an ovarian tumor that created a connection to her skin.
  • After surgery to remove the problematic tissue, she took antibiotics for six months and showed no signs of the disease coming back after two years.
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Article Synopsis
  • - Malacoplakia is a rare chronic disease affecting mainly the gastrointestinal and urinary tracts, particularly in immunocompromised patients, and seldom involves the female reproductive tract; a case report details a 56-year-old woman's experience with cervical and vaginal malacoplakia post-thymectomy.
  • - The patient had recurrent vaginal bleeding, and colposcopy revealed alterations in the cervical pattern suggestive of cervical cancer, while tissue examination showed macrophage aggregation and specific body formations.
  • - Treatment included surgical resection of lesions and antibiotic vaginal lavage, emphasizing a new approach to managing genital malacoplakia in patients with underlying health conditions.
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Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with genitourinary, gastrointestinal, or cutaneous manifestations in immunocompromised or, less commonly, immunocompetent hosts. We describe a case of renal malakoplakia in a young, otherwise healthy patient presenting with nephromegaly and sepsis following an E.

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Article Synopsis
  • Malakoplakia is a rare inflammatory disease primarily affecting the urinary tract.
  • The case presented involves a breast cancer patient who developed diffuse large B-cell lymphoma and was undergoing RCHOP therapy.
  • During her treatment, a PET/CT scan revealed bilateral renal malakoplakia, which was successfully treated with prolonged antibiotic therapy.
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  • The case describes a 34-year-old HIV-positive female experiencing significant vaginal discharge, leading to the discovery of intense plasma cell inflammation in her cervix, which is a rare condition.
  • The study highlights findings from this case, including results from Pap Smear and biopsy, and provides a comparison of similar cases to help differentiate between similar cervical lesions.
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Article Synopsis
  • Malakoplakia is a rare inflammatory disease, primarily affecting the urinary bladder, caused by histiocytes that struggle to kill bacteria.
  • It is characterized by distinct histological features, including sheets of histiocytes and Michaelis-Gutmann bodies, which have a unique target-like appearance.
  • The case study discusses a 60-year-old woman with postmenopausal bleeding and pelvic infections, ultimately diagnosed with endometrial malakoplakia following a surgical procedure.
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Article Synopsis
  • - Prostatic malakoplakia (PMP) is a rare inflammatory condition that can be misdiagnosed through imaging, leading to unnecessary biopsies; this study aimed to summarize the imaging features of PMP in five patients.
  • - All patients, aged 58 to 74 years, underwent ultrasound-guided prostate biopsies which confirmed PMP and excluded prostate cancer; imaging showed high signal lesions on T1-weighted MRI and abnormal prostate morphology on ultrasound.
  • - While PSA levels, MRI, and ultrasound aren't specific indicators of PMP, a history of co-infections could aid in accurate diagnosis and prevent unnecessary biopsies.
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