6 results match your criteria: "Malaghan Institute of Medical Research Wellington New Zealand.[Affiliation]"
Objectives: Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to myelin sheaths. While all current disease-modifying treatments (DMTs) are very effective at reducing relapses, they do not slow the progression of the disease, and there is little evidence that these treatments are able to repair or remyelinate damaged axons. Recent evidence suggests that activating kappa opioid receptors (KORs) has a beneficial effect on the progression of MS, and this study investigates the effects of KOR agonists treatment in combination with two current DMTs.
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- Metastasis is a major cause of death in breast cancer, especially for those with triple-negative breast cancer (TNBC), and current vaccines have not been effective, highlighting the need for new treatments.
- Researchers developed conjugate vaccines that link a glycolipid, which activates NKT cells, to breast cancer-related peptides to stimulate an immune response.
- These vaccines showed promise by enhancing T-cell responses, delaying primary tumor growth, and preventing lung metastasis in breast cancer models, suggesting they could be valuable as supportive therapies for high-risk patients.
Self-adjuvanting vaccines consisting of peptide epitopes conjugated to immune adjuvants are a powerful way of generating antigen-specific immune responses. We previously showed that a -derived peptide conjugated to a rearranged form of α-galactosylceramide (α-GalCer) could stimulate liver-resident memory T (T) cells that were effective killers of liver-stage ANKA (Pba)-infected cells. To investigate if similar or even superior T responses can be induced by modifying the α-GalCer adjuvant, we created new conjugate vaccine cadidates by attaching an immunogenic -derived peptide antigen to 6″-substituted α-GalCer analogues.
View Article and Find Full Text PDFObjectives: Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to the myelin sheath, resulting in physical and cognitive disability. There is currently no cure for MS, and finding effective treatments to prevent disease progression has been challenging. Recent evidence suggests that activating kappa opioid receptors (KOR) has a beneficial effect on the progression of MS.
View Article and Find Full Text PDFCostimulatory signals are required to achieve robust chimeric antigen receptor (CAR) T cell expansion, function, persistence and antitumor activity. These can be provided by incorporating intracellular signalling domains from one or more T cell costimulatory molecules, such as CD28 or 4-1BB, into the CAR. The selection and positioning of costimulatory domains within a CAR construct influence CAR T cell function and fate, and clinical experience of autologous anti-CD19 CAR T cell therapies suggests that costimulatory domains have differential impacts on CAR T cell kinetics, cytotoxic function and potentially safety profile.
View Article and Find Full Text PDFA feasibility study: association between gut microbiota enterotype and antibody response to seasonal trivalent influenza vaccine in adults.
Clin Transl Immunology
March 2018
High-Value Nutrition National Science Challenge Wellington New Zealand.
Objective: We investigated the potential feasibility of a randomized controlled trial of a nutritional intervention that may alter human gut microbiota and support immune defence against respiratory tract infection in adults (Proposed Study).
Methods: In total, 125 healthy adults aged 18-64 participated in a 6-month study that measured antibody response to the seasonal trivalent influenza vaccine. We assessed completion rates, procedure adherence rates and the influence of possible exclusion criteria on potential recruitment into the Proposed Study.