129 results match your criteria: "Majocchi Granuloma"

Article Synopsis
  • Majocchi's granuloma is a dermatological condition where dermatophytes invade deeper skin layers, often triggered by trauma or excessive use of topical corticosteroids.
  • A 57-year-old man experienced itchy skin lesions on his right ankle after using over-the-counter steroids, leading to the diagnosis of Majocchi's granuloma evidenced by clinical and histopathological findings.
  • The patient was treated with oral terbinafine and topical luliconazole, resulting in resolution of lesions within three weeks, though he was advised to continue treatment for two months.
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Article Synopsis
  • - Majocchi's granuloma is a rare fungal skin condition caused mainly by the fungus Trichophyton rubrum and is often linked to the use of topical steroids and weakened immune systems.
  • - Symptoms typically include a rash with nodules, pustules, and scaling around hair follicles, which can be diagnosed through clinical exams and lab tests.
  • - Treatment involves using systemic terbinafine along with topical antifungal medications for effective management.
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Article Synopsis
  • Herpes zoster (HZ) is caused by the reactivation of the varicella-zoster virus (VZV) and is rarely seen occurring alongside fungal infections.
  • The occurrence of HZ at the site of a deep fungal infection has not been documented previously.
  • The text discusses a unique case involving a 45-year-old male who had a Majocchi granuloma superinfected with disseminated herpes zoster.
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Widespread form of Majocchi's granuloma in a kidney transplant recipient.

CEN Case Rep

December 2024

Department of Nephrology, Erciyes University Medical Faculty, Köşk Distinct, Dede Efendi Street, 38039, Melikgazi, Kayseri, Turkey.

Article Synopsis
  • Kidney transplantation is the preferred treatment for kidney failure as it leads to longer survival and improved quality of life, but recipients face a higher risk of infections due to immunosuppression.
  • A rare case of Majocchi's granuloma, a type of fungal skin infection, occurred in a young kidney transplant recipient who was heavily immunosuppressed following acute rejection.
  • The condition spread across the patient's extremities, and after diagnosis through skin biopsy and tissue culture, it was effectively treated with oral terbinafine, highlighting the importance of monitoring for opportunistic infections in transplant patients.
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Article Synopsis
  • - A 32-year-old woman experienced itchy, painful skin lesions in the vulva and on her shins for 2 months, initially treated with corticosteroids and vancomycin without success.
  • - Biopsies revealed Majocchi's granuloma, an infection caused by fungal infiltration in hair follicles, confirmed through growth in tissue culture and further analysis; the patient had recently adopted a guinea pig with similar skin issues.
  • - After being prescribed terbinafine and ketoconazole cream, she showed significant improvement, and after 6 months of treatment, her skin remained clear for 4 months after stopping antifungals; her guinea pig was also treated successfully by a veterinarian.
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Article Synopsis
  • Fungal infections, often mistaken for conditions like eczema or psoriasis, can be difficult to identify and might be improperly treated with topical corticosteroids, leading to a condition called tinea incognita.
  • A 54-year-old man experienced a painful rash in the genitoinguinal area that was initially treated unsuccessfully with various topical antifungals and antibiotics.
  • Ultimately diagnosed with Majocchi's granuloma after thorough examination and histopathology, the patient successfully improved with a 16-week course of itraconazole, highlighting the need for awareness of such infections among non-specialist doctors.
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Majocchi's granuloma-A multicenter retrospective cohort study.

JAAD Int

December 2023

Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota.

Article Synopsis
  • - Majocchi's granuloma (MG) is a rare fungal infection predominantly affecting hair follicles, often linked to previous use of immunosuppressants and corticosteroids, with case data coming from past reports due to its uncommon nature.
  • - A study analyzed 147 adult patients over 30 years, revealing a median patient age of 55.6 years, with most patients being male, and Trichophyton species identified as the primary cause of MG.
  • - Treatment typically involved a median duration of 31.5 days, primarily using oral terbinafine, leading to a successful clinical resolution in 96.6% of patients, although accurate diagnosis usually requires histopathologic confirmation.
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Article Synopsis
  • Deep dermatophytosis is a serious skin infection caused by fungi called Dermatophytes, which can lead to various complications, including deeper skin issues and widespread infections.
  • A case report details a 23-year-old man with scarring alopecia and subcutaneous abscesses, diagnosed with a severe form of dermatophytosis caused by Trichophyton Rubrum.
  • The patient had a mutation in the CARD9 gene, a risk factor identified in the Mediterranean, and after surgery to drain the abscesses and antifungal treatment, he recovered well.
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What Percentage of Hairs Are Infected in Biopsies of Fungal Folliculitis?

Dermatopathology (Basel)

April 2023

Departments of Dermatology and Pathology, Geisinger Medical Center, Danville, PA 17821, USA.

Article Synopsis
  • Fungal folliculitis encompasses conditions like tinea capitis and Majocchi granuloma and can vary greatly in appearance, with biopsies helping to differentiate it from similar issues.
  • A study examined 72 biopsy cases to determine the proportion of infected hairs, finding that on average 54.2% were infected, but results varied based on the biopsy location.
  • The study warns that when biopsies contain very few hairs, there's a higher risk of misdiagnosing fungal folliculitis, as missing infected hairs can result in false negatives.
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Facial Majocchi's granuloma.

IDCases

April 2023

Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN, USA.

Article Synopsis
  • Majocchi's granuloma (MG) is a rare type of skin infection that occurs in hair follicles, usually caused by dermatophytes (a group of fungi).
  • The condition is specifically identified as a form of deep fungal folliculitis, which means it affects deeper layers of the skin and hair follicles.
  • This report highlights a specific case involving MG that appeared on the face, showcasing the condition's impact on facial skin.
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Histopathology in the Diagnosis of Tinea Capitis: When to Do, How to Interpret?

Mycopathologia

October 2023

Department of Dermatology, Faculty of Medicine, Adana Dr. Turgut Noyan Application and Research Center, Başkent University, Adana, Turkey.

The diagnosis of tinea capitis is usually made by clinical signs and direct microscopic examination. Early diagnosis of this dermatophytic infection, which may cause permanent hair loss if not treated appropriately, is very crucial. In recent years, the use of dermoscopy has helped with early diagnosis.

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Article Synopsis
  • Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare condition that can affect multiple systems, including causing eosinophilic myocarditis, which impacts the heart.
  • A 67-year-old woman presented with breathing difficulties, a history of asthma, and tests indicated heart dysfunction, elevated troponin levels, and peripheral eosinophilia.
  • Imaging techniques ruled out coronary heart disease but revealed lung issues, and a biopsy confirmed inflammation in the heart, leading to treatment with corticosteroids and heart failure medications.
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Article Synopsis
  • The review discusses inflammatory tinea, a rare group of fungal skin and hair infections, focusing on its causes, symptoms, diagnosis, and treatment options, including specific conditions like Majocchi's granuloma and Hadida's disease.
  • New classifications of dermatophytes identify nine genera, with recent research showing that inflammatory tinea can lead to weakened antifungal immune responses in affected individuals.
  • Understanding the impaired immune responses is crucial for effective diagnosis and treatment of these conditions, emphasizing the need for healthcare professionals to recognize these immunological aspects.
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Article Synopsis
  • Trichophyton rubrum, a fungus causing skin infections, can occasionally lead to deeper tissue problems like granulomas, and few cases have shown genetic evidence for self-infection.
  • Researchers aimed to identify genetic changes in T. rubrum due to autoinoculation by analyzing strains collected from different body sites in a case of Majocchi's granuloma.
  • Whole-genome sequencing revealed notable genetic differences between the isolates, suggesting adaptation to distinct environments and proposing a theory on how the fungus adjusts for deeper tissue invasion based on the unique conditions of each site.
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ALA-PDT successfully treated Majocchi's granuloma by directly killing Trichophyton tonsurans and recruiting T lymphocytes.

Photodiagnosis Photodyn Ther

September 2021

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Baode Road 1278, Shanghai, 200443, China. Electronic address:

Article Synopsis
  • - Majocchi's granuloma (MG) is a persistent skin infection possibly caused by the fungus Trichophyton tonsurans, commonly treated with antifungal drugs, which show limited success and high relapse rates.
  • - A case study used ALA-PDT (Aminolevulinic Acid Photodynamic Therapy) on a patient with recurrent MG, finding that three treatments led to the complete resolution of the lesions and fungi.
  • - Both in vitro and in vivo studies confirm that ALA-PDT effectively inhibits T. tonsurans growth by damaging fungal cell structures and activating the immune response (specifically CD4+ T cells).
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Majocchi's granuloma caused by after facial injection with hyaluronic acid: A case report.

World J Clin Cases

September 2020

Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.

Article Synopsis
  • Increasing popularity of facial cosmetic procedures has led to complications, particularly infections, with this case highlighting Majocchi's granuloma (MG) resulting from hyaluronic acid injections.
  • A 37-year-old woman experienced red papules and abscesses on her face two months after the injection, which were diagnosed as MG and treated with antifungals.
  • The patient's treatment switched from terbinafine to itraconazole after testing showed better efficacy, leading to significant improvement and no recurrence.
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