161 results match your criteria: "Maison Blanche Hospital[Affiliation]"

Background: Results of genetic have led to off-label glibenclamide treatment in patients with neonatal diabetes (NDM) because of potassium channel mutations. No pediatric form of glibenclamide was available. Glibenclamide was designated an orphan drug designation for NDM and a suspension was developed.

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Safety of combination therapy with two bDMARDs in patients with rheumatoid arthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum

August 2019

Rheumatology Department, Maison Blanche Hospital, Reims University Hospitals, 45 Rue Cognacq-Jay, Reims 51092, France; Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, 51095 Reims, France. Electronic address:

Objectives: We performed a systematic review and meta-analysis of the current literature to assess the safety of combining two biologic disease-modifying antirheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA).

Methods: We systematically searched for controlled studies evaluating safety in patients with RA treated with two bDMARDs independently of dose-regimen. Databases used were MEDLINE (via Pubmed), EMBase, Cochrane Library, Scopus, ClinicalTrials.

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Uterus-like mass: A case report.

Eur J Obstet Gynecol Reprod Biol

February 2019

Department of Obstetrics and Gynecology, Maison Blanche Hospital, Reims-Champagne-Ardennes University, Reims, France. Electronic address:

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Threshold for a Reduction in Anticholinergic Burden to Decrease Behavioral and Psychological Symptoms of Dementia.

J Am Med Dir Assoc

February 2019

Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, France; Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, France. Electronic address:

Background: A high anticholinergic burden (AB) is associated with the occurrence of behavioral and psychological symptoms (BPSDs), which are frequent in dementia.

Objectives: Our aim was to determine the threshold for a reduction in AB that would lead to a clinically significant improvement in BPSDs (in terms of frequency, severity, and disruptiveness).

Design: A single-center prospective study.

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16p13.11 microduplication in 45 new patients: refined clinical significance and genotype-phenotype correlations.

J Med Genet

May 2020

Department of Histology Embryology and Cytogenetics, Jean Verdier Hospital; Paris 13 University, Sorbonne Paris Cité, UFR SMBH Bobigny; PROTECT, INSERM, Paris Diderot University, Bondy, France.

Article Synopsis
  • * Analysis of data from over 16,000 patients reveals key clinical features, such as speech delays, learning disabilities, and a noted increase in cardiovascular disease risk, with most duplications inherited from parents.
  • * The research suggests that 16p13.11 microduplications are likely harmful in the context of neurocognitive disorders, indicating that further cardiac evaluations are necessary and highlighting the significance of specific genetic factors like miR-484.
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Elastin is a long-lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient.

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Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?

Medicine (Baltimore)

August 2018

Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims Department of Internal Medicine and Infectious Diseases, Manchester Hospital, Charleville-Mézières Department of Dermatology, Robert Debré Hospital Laboratory of Pathology, Maison Blanche Hospital, University Hospital, Reims Department of Dermatology, Saint-Louis Hospital, Paris, France.

Rationale: Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) has rarely been reported.

Patient Concerns: We report here 2 cases of this association.

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Background: The place of disease-modifying osteoarthritis drugs (DMOADs) and intra-articular hyaluronic acid (IAHA) in the therapeutic arsenal for knee osteoarthritis (OA) remains uncertain. Indeed, these treatments have demonstrated symptomatic efficacy but no efficacy for disease modification.

Objective: This report reviews the cost effectiveness of IAHA and DMOADs used in the treatment of knee OA.

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The complement receptor 1 () gene was shown to be involved in Alzheimer's disease (AD). We previously showed that AD is associated with low density of the long CR1 isoform, CR1*2 (S). Here, we correlated phenotype data (CR1 density per erythrocyte (CR1/E), blood soluble CR1 (sCR1)) with genetic data (density/length polymorphisms) in AD patients and healthy controls.

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Background: Evaluation of health-related quality of life (HRQoL) in patients with Alzheimer's disease (AD) is necessary to ensure optimal management. Several scales for assessing HRQoL of patients with AD exist, in particular the Quality of Life in Alzheimer's Disease (QoL-AD), which includes an evaluation by the caregiver of the patient's HRQoL. The aim of this study was to identify factors associated with patient, caregiver and overall HRQoL as assessed by the QoL-AD.

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Background: Because cognitive processes decline in the earliest stages of Alzheimer's disease (AD), the driving abilities are often affected. The naturalistic driving approach is relevant to study the driving habits and behaviors in normal or critical situations in a familiar environment of participants.

Objective: This pilot study analyzed in-car video recordings of naturalistic driving in patients with early-stage AD and in healthy controls, with a special focus on tactical self-regulation behavior.

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Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression.

Parasite

January 2019

EA 7510, ESCAPE, Laboratory of Parasitology-Mycology, University of Reims Champagne-Ardenne, 51100 Reims, France - Laboratory of Parasitology-Mycology, Toxoplasmosis National Reference Center, Toxoplasma Biological Resource Center, Maison Blanche Hospital, 51100 Reims, France.

Metallopeptidases are a family of proteins with domains that remain highly conserved throughout evolution. These hydrolases require divalent metal cation(s) to activate the water molecule in order to carry out their catalytic action on peptide bonds by nucleophilic attack. Metallopeptidases from parasitic protozoa, including Toxoplasma, are investigated because of their crucial role in parasite biology.

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Background: In 2006, a local collective combating homelessness set up an 'experimental squat' in an abandoned building in Marseille, France's second largest city. They envisioned the squat as an alternative to conventional health and social services for individuals experiencing long-term homelessness and severe psychiatric disorders. Building on what they learned from the squat, some then joined a larger coalition that succeeded in convincing national government decision-makers to develop a scientific, intervention-based programme based on the Housing First model.

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Autoantibodies Associated With Connective Tissue Diseases: What Meaning for Clinicians?

Front Immunol

May 2019

Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debré Hospital, Reims, France.

Connective tissue diseases (CTDs) such as systemic lupus erythematosus, systemic sclerosis, myositis, Sjögren's syndrome, and rheumatoid arthritis are systemic diseases which are often associated with a challenge in diagnosis. Autoantibodies (AAbs) can be detected in these diseases and help clinicians in their diagnosis. Actually, pathophysiology of these diseases is associated with the presence of antinuclear antibodies.

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This paper is a qualitative analysis of the effects of , a support framework, on recovery trajectories of people with long-term homelessness and severe psychiatric disorders during 24 months in a Housing First-type program in France. A comprehensive methodology based on grounded theory was used to construct an interview guide, conduct multiple interviews with 35 Housing First participants sampled for heterogeneity, and produce memos on their trajectories before and after entering the program based on interview information. Thematic analysis of a representative subsample ( = 13) of memos identified 12 objective factors and 6 subjective factors key to the recovery process.

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Background: Little is known about xeroderma pigmentosum (XP) in Himalayan countries.

Objective: To describe clinical characteristics of XP in Nepal and investigate its genetic bases.

Methods: This study was carried out on all consecutive patients referred for XP to a Nepalese tertiary referral centre in 2014-2015.

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We assessed prognostic factors in relation to OS from progression in recurrent glioblastomas. Retrospective multicentric study enrolling 407 (training set) and 370 (external validation set) adult patients with a recurrent supratentorial glioblastoma treated by surgical resection and standard combined chemoradiotherapy as first-line treatment. Four complementary multivariate prognostic models were evaluated: Cox proportional hazards regression modeling, single-tree recursive partitioning, random survival forest, conditional random forest.

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Objective: The aim was to evaluate the incidence of serious infusion-related reactions (SIRRs) in RA treated by non-TNF-targeted biologics.

Methods: We analysed data from three independent prospective registers, namely autoimmunity and rituximab, Orencia (abatacept) and RA (ORA) and Registry RoAcTEmra (tocilizumab), promoted by the French Society of Rheumatology and including patients with RA. SIRRs were defined by an occurrence during or within 24 h of an infusion and requiring discontinuation of treatment.

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Association between hidradenitis suppurativa and spondyloarthritis.

Joint Bone Spine

October 2018

Rheumatology Department, Maison-Blanche Hospital, Reims University Hospitals, 51092 Reims, France; Rheumatology Department, Le-Mans Hospital, 72037 Le Mans, France.

Article Synopsis
  • The study aimed to explore whether there is a link between hidrosadenitis suppurativa (a skin condition) and spondyloarthritis (a type of arthritis) by comparing patients with the skin condition to healthy volunteers.
  • Researchers conducted a cross-sectional study at a tertiary care center and found that 28.2% of patients with hidrosadenitis suppurativa had spondyloarthritis, compared to only 2.6% in the control group.
  • The findings suggest a significant association between hidrosadenitis suppurativa and an increased risk of spondyloarthritis, highlighting the need for monitoring patients with the skin condition for related joint symptoms.
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Background And Aim: To improve the diagnostic work-up of patients with diverse neurological diseases, we have elaborated specific clinical and CSF neurotransmitter patterns.

Methods: Neurotransmitter determinations in CSF from 1200 patients revealed abnormal values in 228 (19%) cases. In 54/228 (24%) patients, a final diagnosis was identified.

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Reduction of the Anticholinergic Burden Makes It Possible to Decrease Behavioral and Psychological Symptoms of Dementia.

Am J Geriatr Psychiatry

March 2018

Departments of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, France; Faculty of MedicineEA 3797, University of Reims Champagne-Ardenne, Reims, France.

Objective: The aim of this study was to evaluate the impact of a reduction of the anticholinergic burden (AB) on the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) and their repercussions on the care team (occupational disruptiveness).

Methods: In this prospective, single-center study in an acute care unit for Alzheimer disease (AD) and related disorders, 125 elderly subjects (mean age: 84.4 years) with dementia presented with BPSD.

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Screening for frailty in community-dwelling elderly subjects: Predictive validity of the modified SEGA instrument.

Arch Gerontol Geriatr

November 2017

University of Reims Champagne-Ardenne, Faculty of Medicine, E.A 3797, Reims, F-51095, France; Reims Teaching Hospitals, Maison Blanche Hospital, Department of Geriatrics and Internal Medicine, Reims, F-51092, France.

Aims: To study the capacity of the SEGAm instrument to predict loss of independence among elderly community-dwelling subjects.

Methods: The study was performed in four French departments (Ardennes, Marne, Meurthe-et-Moselle, Meuse). Subjects aged 65 years or more, living at home, who could read and understand French, with a degree of autonomy corresponding to groups 5 or 6 in the AGGIR autonomy evaluation scale were included.

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New techniques in interventional neuroradiology: Should we really randomize the first patient?

J Neuroradiol

September 2017

Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797 Reims, France; Department of Research and Public Health, University hospitals of Reims, Robert Debré Hospital, Reims, France.

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Is functional mobility an independent mortality risk factor in subjects with dementia?

Maturitas

September 2017

Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, F-51092, France; Department of Research and Public Health, Reims University Hospitals, Robert Debré Hospital, Reims, F-51092, France.

Objective: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia.

Study Design: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible.

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(Diptera: Ceratopogonidae) serve as vectors of several mammalian and avian diseases, including bluetongue, Schmallenberg, African horse sickness, avian malaria and Oropouche. Host preference investigations are necessary to assess the transmission routes of vector-borne diseases and to inform mitigation strategies. A recent study examining the main sensory structures (palps and antennae) of species suggests that they be classified as ornithophilic or mammalophilic according to their feeding habits.

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