2 results match your criteria: "MaineHealth Institute for Research (MHIR)[Affiliation]"
The transcriptome of acute dehydration in myeloid leukemic cells.
Postepy Biochem
May 2024
MaineHealth Institute for Research (MHIR), Scarborough, ME, USA.
Human myeloid leukemia cells (HL-60/S4) exposed to hyperosmotic stress with sucrose undergo dehydration and cell shrinkage. Interphase chromatin and mitotic chromosomes congeal, exhibiting altered phase separation (demixing) of chromatin proteins. To investigate changes in the transcriptome, we exposed HL-60/S4 cells to hyperosmotic sucrose stress (~600 milliOsmolar) for 30 and 60 minutes.
View Article and Find Full Text PDFThe Maine Cancer Genomics Initiative: Implementing a Community Cancer Genomics Program Across an Entire Rural State.
JCO Precis Oncol
May 2023
The Jackson Laboratory for Genomic Medicine, Farmington, CT.
Article Synopsis
- - The Maine Cancer Genomics Initiative (MCGI) aimed to improve genomic tumor testing access for cancer patients in rural Maine through genomic tumor boards, clinician education, and free testing services from 2016 to 2020.
- - A hub-and-spoke model was adopted for the initiative, involving a centralized genomic tumor board program, an online education module, and comprehensive testing that engaged all 19 oncology practices in Maine, with participation from 79 oncologists.
- - The initiative successfully enrolled 1610 patients, held 196 genomic tumor boards with 47 clinicians, and achieved significant improvements in clinician participation and patient enrollment in a rural setting, enhancing precision oncology accessibility.