Evaluation of magnetic hyperthermia, drug delivery and biocompatibility (bone cell adhesion and zebrafish assays) of trace element co-doped hydroxyapatite combined with Mn-Zn ferrite for bone tissue applications.

The treatment and regeneration of bone defects, especially tumor-induced defects, is an issue in clinical practice and remains a major challenge for bone substitute material invention. In this research, a composite material of biomimetic bone-like apatite based on trace element co-doped apatite (Ca M (PO)(CO)(OH); M = trace elements of Mg, Fe, Zn, Mn, Cu, Ni, Mo, Sr and BO ; THA)-integrated-biocompatible magnetic Mn-Zn ferrite ((Mn, Zn)FeO nanoparticles, BioMags) called THAiBioMags was prepared a co-precipitation method. Its characteristics, , physical properties, hyperthermia performance, ion/drug delivery, were investigated using osteoblasts (bone-forming cells) and using zebrafish.

Correction: Effects of alcohols as sacrificial reagents on a copper-doped sodium dititanate nanosheets/graphene oxide photocatalyst in CO photoreduction.

[This corrects the article DOI: 10.1039/D4RA04585H.].

Effects of alcohols as sacrificial reagents on a copper-doped sodium dititanate nanosheets/graphene oxide photocatalyst in CO photoreduction.

Carbon dioxide (CO) photoreduction is an intriguing approach that converts CO into high-value substances with the assistance of a photocatalyst. Key to effective photoreduction is to promote the interaction of photo-induced holes and a sacrificial reagent (SCR), separating the holes from photoelectrons and enhancing the rate of the subsequent product generation. Methanol, ethanol, isopropanol, and water SCRs were tested for their ability to assist a copper-doped sodium dititanate nanosheets/graphene oxide heterostructure (CTGN) in CO photoreduction.

Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection.

This study involved designing, synthesizing, and evaluating the protective potential of compounds on microglial cells (BV-2 cells) and neurons (SH-SY5Y cells) against cell death induced by Aβ. It aimed to identify biologically specific activities associated with anti-Aβ aggregation and understand their role in oxidative stress initiation and modulation of proinflammatory cytokine expression. Actively designed compounds CE5, CA5, PE5, and PA5 showed protective effects on BV-2 and SH-SY5Y cells, with cell viability ranging from 60.

Development and evaluation of ursolic acid-loaded poly(lactic--glycolic acid) nanoparticles in cholangiocarcinoma.

Cholangiocarcinoma (CCA), an epithelial biliary tract malignancy, is a significant health concern in the Greater Mekong Subregion, particularly in northeastern Thailand. Prior to the development of advanced stages, CCA is typically asymptomatic, thereby limiting treatment options and chemotherapeutic effectiveness. Ursolic acid (UA), a triterpenoid derived from plants, was previously discovered to inhibit CCA cell growth through induction of apoptosis.

Preparation and evaluation of a niosomal delivery system containing extract and study of its anti- activity.

extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety of bioactive components. GME has proven its anti- effectiveness. In this investigation, a GME-loaded niosome was developed to increase its potential therapeutic efficacy.

Investigation on the physical properties and biocompatibility of zirconia-alumina-silicate@diopside composite materials and its toxicity study in embryonic zebrafish.

Bioceramic materials have a wide range of applications in the biomedical field, such as in the repair of bone defects and dental surgery. Silicate-based bioceramics have attracted biomedical researchers' interest due to their bioactivity and biodegradability. In this study, extended the scope of ZAS utilization in bone tissue engineering by introducing calcium-magnesium-silicate (diopside, CMS) as an interface material aim to develop a machinable bioceramic composite (ZASCMS) by the sol-gel method.

An irreversible paper-based profluorescent nitroxide probe for the selective detection of ascorbic acid.

Ascorbic acid (AA) or vitamin C plays multiple crucial roles, particularly as an antioxidant. This essentially biologically active molecule was selectively detected over other reductants by the synthesized profluorescent nitroxide probe ProN6 a switch-on method. After either a hydrogen atom or single electron transfer from AA to nitroxide, the resulting diamagnetic hydroxylamine was rapidly cyclized to form a fluorescent -acylalkoxyamine.

ALA-A2 Is a Novel Anticancer Peptide Inspired by Alpha-Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation.

Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However, traditional laboratory screening to find and identify novel ACPs from hundreds to thousands of peptides is costly and time consuming. Here, a sequential procedure is applied to identify candidate ACPs from a computer-generated peptide library inspired by alpha-lactalbumin, a milk protein with known anticancer properties.

Rapid detection of cancer DNA in human blood using cysteamine-capped AuNPs and a machine learning-enabled smartphone.

DNA methylation occurs when a methyl group is added to a cytosine (C) residue's fifth carbon atom, forming 5-methylcytosine (5-mC). Cancer genomes have a distinct methylation landscape (Methylscape), which could be used as a universal cancer biomarker. This study developed a simple, low-cost, and straightforward Methylscape sensing platform using cysteamine-decorated gold nanoparticles (Cyst/AuNPs), in which the sensing principle is based on methylation-dependent DNA solvation.

Riboflavin-citrate conjugate multicore SPIONs with enhanced magnetic responses and cellular uptake in breast cancer cells.

Breast cancer accounts for up to 10% of the newly diagnosed cancer cases worldwide, making it the most common cancer found in women. The use of superparamagnetic iron oxide nanoparticles (SPIONs) has been beneficial in the advancement of contrast agents and magnetic hyperthermia (MH) for the diagnosis and treatment of cancers. To achieve delivery of SPIONs to cancer cells, surface functionalization with specific ligands are required.

Dual determination of nitrite and iron by a single greener sequential injection spectrophotometric system employing a simple single aqueous extract from Linn. serving as a natural reagent.

Dual determination of nitrite and iron was proposed by using a single greener sequential injection (SI) spectrophotometric system employing a simple single aqueous extract from Linn. The extract served as a natural reagent to replace -(1-naphthyl)ethylenediamine (NED) of the Griess reagent with nitrite and 1,10-phenanthroline with iron. The color products possessed analytical wavelengths at 430 and 560 nm, respectively.

Fabrication of biocompatible magneto-fluorescence nanoparticles as a platform for fluorescent sensor and magnetic hyperthermia applications.

Multifunctional nanoparticles with special magnetic and optical properties have been attracting a great deal of attention due to their important applications in the bioanalytical and biomedical fields. In this study, we report the fabrication of biocompatible magneto-fluorescence nanoparticles consisting of carbon dots (CDots) and silica-coated cobalt-manganese nanoferrites (CoMnFeO) (CoMnF@Si@CDots) (MagSiCDots) by a facile hydrothermal method. The as-prepared MagSiCDots have a particle size of 100-120 nm and show a negative zeta potential of -35.

A model of modified -iodobenzylguanidine conjugated gold nanoparticles for neuroblastoma treatment.

Iodine-131 -iodobenzylguanidine (I-IBG) has been utilized as a standard treatment to minimize adverse side effects by targeting therapies to bind to the norepinephrine transporter (NET) expressed on 90% of neuroblastoma cells. However, only a minority of patients who receive I-IBG radiotherapy have clinical responses, and these are usually not curative. In this study, novel ligand-conjugated gold nanoparticles (GNPs) based on IBG were synthesized and evaluated biologically with neuroblastoma cells .

Effect of silver nanospheres and nanowires on human airway smooth muscle cells: role of sulfidation.

: The toxicity of inhaled silver nanoparticles on contractile and pro-inflammatory airway smooth muscle cells (ASMCs) that control airway calibre is unknown. We explored the oxidative activities and sulfidation processes of the toxic-inflammatory response. : Silver nanospheres (AgNSs) of 20 nm and 50 nm diameter and silver nanowires (AgNWs), short S-AgNWs, 1.

Uniform Cu/chitosan beads as a green and reusable catalyst for facile synthesis of imines oxidative coupling reaction.

A nonprecious metal and biopolymer-based catalyst, Cu/chitosan beads, has been successfully prepared by using a software-controlled flow system. Uniform, spherical Cu/chitosan beads can be obtained with diameters in millimeter-scale and narrow size distribution (0.78 ± 0.

Modifying morphology and defects of low-dimensional, semi-transparent perovskite thin films solvent type.

(PEA)(MA) Pb I Br perovskites are semi-transparent, color-tunable thin films with broader band gaps. They have the potential for semi-transparent solar cell and smart window applications. Solvent engineering significantly alters the morphology, absorbance, crystallinity, charge separation, and defects, thereby influencing the optoelectronic properties.

Electrospun cellulose acetate doped with astaxanthin derivatives from for anti-aging activity.

This research aims to study the release, anti-aging activity against and stability of astaxanthins in a crude acetone extract of from electrospun cellulose acetate (CA) nanofibers. The content and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging activity of astaxanthins in the crude extract were also determined. The content of astaxanthins was reported in terms of total carotenoid content (TCC) and found to be 10.

Structural modification of oridonin DAST induced rearrangement.

A simple and efficient protocol was developed for the syntheses of oridonin analogues, 6,20-epoxy -kaurane diterpenoid analogues from oridonin diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.

New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of .

Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit.

Unusual manifestation of vitamin A deficiency presenting with generalized xerosis without night blindness.

Vitamin A deficiency from malabsorption syndromes, including bariatric surgery, has become an emerging problem in developed countries. Early detection and prompt treatment lead to rapid and complete recovery. Nevertheless, it may result in irreversible blindness or death if left untreated.

Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma.

High-dose intravenous thyroxine (T4) is the preferable treatment for myxedema coma. We describe the clinical course of a 69-year-old man who presented with myxedema coma and received oral levothyroxine (LT4) therapy (1 mg) in a split dose. This suggests split high-dose oral LT4 as a therapeutic option in myxedema coma.

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions.