Phytochemical analysis and acute toxicity study of seaweed using Wistar albino rats.

Objectives: a seaweed commonly known as green macroalgae is a potential source of bioactive compounds utilised in nutraceuticals and pharmaceuticals. However, there are no reliable scientific studies that describe harmful consequences, which attest to its safety. Thus, the current investigation focuses on a 14-day acute toxicity assessment of hydroalcoholic extract (HME).

A Comprehensive Review on Harnessing Wearable Technology for Enhanced Depression Treatment.

Depression is a prevalent and debilitating mental health disorder that significantly impacts individuals, families, and societies worldwide. Despite advancements in treatment, challenges remain in effectively managing and monitoring depressive symptoms. Wearable technology, which encompasses devices that can monitor physiological and behavioral parameters in real time, offers promising new avenues for enhancing depression treatment.

Antibiotic Resistance Profiles of Extended-Spectrum β-Lactamase (ESBL)- and Metallo-β-Lactamase (MBL)-Producing Klebsiella pneumoniae Isolates From Diabetic Foot Ulcers: Implications for Treatment Strategies.

Background Diabetic foot ulcers (DFUs) are prevalent complications of diabetes mellitus, often leading to severe infections and adverse clinical outcomes. , a gram-negative bacterium, has emerged as a significant causative agent in DFU infections, raising concerns due to its increasing antibiotic resistance, particularly in extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL) production. Aim This study aimed to comprehensively assess the prevalence, antibiotic resistance profiles, and clinical correlates of ESBL- and MBL-producing isolates specifically derived from DFUs.

Silent but Significant: A Case Report of Appendiceal Mucocele.

Appendiceal mucocele is a rare disease that can sometimes mimic acute appendicitis or be discovered accidentally during surgeries. The clinical presentation of appendiceal mucocele is observed as lumen distension due to mucin accumulation. This condition has both benign and malignant underlying etiologies, which can be confirmed by histopathological examination.

Comparison of isometric handgrip test among pregnant offspring of hypertensive parents and pregnant offspring of non-hypertensive parents.

Context: A family history of hypertension is one of the important risk factors for the development of pregnancy-induced hypertension (PIH). Offspring of hypertensive parents should be screened for PIH. The isometric handgrip (IHG) test is used to assess autonomic function among them.

Identification of the novel HLA-B*49:01:01:22 allele in an Indian renal transplant donor by next generation sequencing.

HLA-B*49:01:01:22 differs from HLA-B*49:01:01:01 by a single nucleotide C->G change in intron 5 at gDNA 2451.

Clinical and Hematological Correlates of Hemolytic Anemia in Diabetic Foot Ulcer Patients: A Prospective Observational Study.

Background Diabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus and are often accompanied by various complications including hemolytic anemia. However, the clinical and hematological correlates of hemolytic anemia in patients with DFU remain poorly understood. This prospective observational study aimed to investigate the clinical and hematological correlates of hemolytic anemia in patients with DFU and to elucidate the potential mechanisms underlying this complication and its impact on wound healing.

Successful Management of Severe Low Back Pain with Ayurveda in Lumbar Spondylosis: A Case Report.

Lumbar spondylosis is a common condition that is quite prevalent, affecting 57% of Indian men. Ayurveda, an indigenous medical system, is highly efficient in treating this ailment when it is in a mild to moderate state. This case report aims to provide a detailed account of a successfully managed case of lumbar spondylosis characterized by severe lumbar pain.

Prosthesis Usage and Functional Status in Upper Limb Amputees: A Prospective Cross-Sectional Study.

Introduction Amputation poses significant challenges encompassing psychological, physical, and socio-economic dimensions, impacting individuals and society at large. In India, a substantial portion of the population faces loco-motor disabilities, with amputees forming a notable segment. Prosthetic rehabilitation plays a crucial role in mitigating the consequences of limb loss, aiming to restore autonomy post-amputation.

Association Between Dynapenia, Central Obesity, and Physical Function in Young Adults: A Cross-Sectional Study.

Background: Muscle strength is recognized as a key indicator of overall health and can help identify the risk of cardiometabolic disease. This study explores the relationship between low muscle strength, central obesity, and physical function among young adults.

Methods: We conducted a cross-sectional study from a convenience sample of 513 adults aged 18-25.

Evaluation of Pediatric Early Warning Score (PEWS) in Unintentional Childhood Injuries Admitted to the Critical Care Unit.

Introduction: Pediatric Early Warning Score (PEWS), also known as Brighton PEWS or Monaghan PEWS, was developed to identify children at risk for clinical deterioration in hospitals. We designed this study to describe the epidemiology of unintentional injuries in children admitted to the critical care unit in a tertiary healthcare setting, and to determine the predictive properties of PEWS in these injuries.

Methods: This is a cross-sectional study.

Evaluation of Serum Cancer Antigen (CA)-125 Levels as a Biomarker for Ovarian Lesions: Correlation With Histopathological Diagnosis and Clinical Outcomes.

Background:  Ovarian cancer is a significant cause of morbidity and mortality among women worldwide. Early detection and accurate diagnosis are crucial for improving patient outcomes. Serum biomarkers, such as cancer antigen 125 (CA-125), have shown promise in aiding the diagnosis and monitoring of ovarian lesions.

Comparative Analysis of Accuracy, Readability, Sentiment, and Actionability: Artificial Intelligence Chatbots (ChatGPT and Google Gemini) versus Traditional Patient Information Leaflets for Local Anesthesia in Eye Surgery.

Background And Aim: Eye surgeries often evoke strong negative emotions in patients, including fear and anxiety. Patient education material plays a crucial role in informing and empowering individuals. Traditional sources of medical information may not effectively address individual patient concerns or cater to varying levels of understanding.

Increased shedding of PECAM-1 associated with elevated serum MMP-14 levels as new blood indicators of dengue disease manifestation.

Objectives: Host factors that regulate plasma leakage during severe dengue (SD) are under investigation. While PECAM-1 and MMP-14 have been reported to regulate vascular integrity, their role in dengue pathogenesis remains unexplored. This study aims to assess the association of soluble PECAM-1 and MMP-14 with dengue severity symptoms.