PWWP2A/B: Prominent players in the proteomic landscape.

The PWWP domain is a conserved motif unique to eukaryotes, playing a critical role in various cellular processes. Proteins containing the PWWP domain are typically found in chromatin, where they bind to DNA and histones in nucleosomes, facilitating chromatin-associated functions. Among these proteins, PWWP-domain containing proteins 2A and 2B (PWWP2A and PWWP2B), identified during the H2A interactome analysis, are DNA methyltransferase-related proteins, that are structurally disordered, except for their PWWP domain.

Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study.

Background: Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.

Methods: This cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities.

Low-Grade Myofibroblastic Sarcoma of the Acetabulum - A Rare Case with Review of Literature.

Introduction: Low-grade myofibroblastic sarcoma (LGMS) is an atypical and extremely infrequent type of tumor, primary mass being usually present in subcutaneous and soft tissue. Bony involvement is very rare. It has a very high chance of recurrence locally due to its aggressive biological behavior, metastasis in other parts of body is rarely seen.

Exploring the regulatory role of small RNAs in modulating host-pathogen interactions: implications for bacterial and viral infections.

MicroRNAs (miRNAs) and transfer RNA-derived stress-induced RNAs (tiRNAs) have emerged as crucial players in the post-transcriptional regulation of gene expression in various cellular processes, including immunity and host defense against infections. In recent years, increasing evidence has highlighted their complex role in influencing the host response during viral and bacterial infections. miRNAs have been shown to play multiple roles in host-pathogen interaction like TLR activation and altered disease virulence during bacterial infections.

Temporal pattern and effect of COVID-19 on the trend of TB, DRTB, paediatrics TB and TB with HIV Coinfection: A decadal trend analysis.

Background: India shares 2/3 of global TB burden. MDR and HIV coinfections are the main obstacle in achieving the successful TB control because it decrease the therapy effect.

Objective: To analyze the long-term trends of incidence of tuberculosis cases and identify any differences between actual and projected cases after the COVID-19 pandemic.

Cardiovascular wellness in low-resource settings: A mobile app-based risk prediction study among fuel filling station employees in Puducherry district.

Background: India is witnessing a significant increase in the prevalence of non-communicable diseases (NCDs), and addressing this requires a comprehensive and multi-faceted approach. The burden of NCDs puts a strain on the healthcare system, requiring an increased focus on preventive measures, early detection, and management of chronic conditions. Adopting a risk-based approach to cardiovascular diseases (CVDs) in resource-poor settings offers several economic and social advantages.

Challenges in diagnosis and management of xanthogranulomatous salpingo-oophoritis: A rare case.

Introduction And Importance: Xanthogranulomatous inflammation of the female genital tract is a rare condition involving ovarian tubes characterized by chronic inflammation and destruction of pelvic organs, often mimicking pelvic malignancy.

Case Presentation: A 37-year-old female with a history of chronic kidney disease, hypertension, and treated pulmonary tuberculosis, presented with lower abdominal fullness, pain, and irregular menstrual cycles.

Clinical Discussion: Radiological investigations revealed a significant left adnexal mass, suggesting a tubo-ovarian abscess or neoplastic lesion.

Osteoporosis Knowledge Assessment Tool - Tamil (OKAT-T) in postmenopausal women: A validity and reliability study.

Introduction: Osteoporosis is a silent disease that is more prevalent among postmenopausal women (PMW) due to hormonal transition. Various toolkits, including the Osteoporosis Knowledge Assessment Tool (OKAT), were available for the knowledge assessment. The Osteoporosis-related knowledge is crucial for preventing osteoporosis, but there is no validated, reliable questionnaire in Tamil to measure this knowledge.

Isolated third cranial nerve palsy in benign idiopathic intracranial hypertension.

Idiopathic intracranial hypertension (IIH) is marked by increased intracranial pressure without any accompanying evidence of clinical, imaging or laboratory findings of intracranial pathology. In addition to headache, nausea and vomiting, typical symptoms might also include diplopia, photophobia and blurred vision. Third nerve palsy is rarely linked to IIH, although sixth nerve palsy is reported in the majority of individuals with IIH.

Script Concordance Test in Physiology: Preparation, Scoring, and Student Perceptions - A Mixed Method Study.

Background: Although the curriculum has changed, assessment tools are not in alignment with the new types of teaching such as early clinical exposure (ECE) and self-directed learning. Both in summative and formative assessment most commonly used tools for assessment of cognitive domain are written formats including MCQ. However, these assessment tools such as MCQ and written essays cannot assess the higher order thinking skills and clinical reasoning skills.

Retrospective Audit of Transfusion Reactions in a Tertiary-Care Hospital in South India.

Background: Blood transfusion is a double-edged sword, as it is a life-saving intervention but is also associated with various adverse reactions. However, blood transfusion safety can be improved by identifying these adverse reactions and taking appropriate interventions. Therefore, in this study, we aimed to determine the frequency and type of transfusion reactions occurring among in-patients at our hospital, as reported to our institute's blood center.

Association between biomass cooking fuels and prevalence of tuberculosis among households: a cross-sectional study from 2019 - 2021 in India.

Background: Indoor air pollution (IAP) is the major contributor (26%) to TB, in addition to other socioeconomic and environmental factors. It occurs in most developing countries like India, where people rely on the combustion of biomass-based solid fuels (low combustion efficiency and high pollution emissions) due to the prevailing socio-economic conditions. However, this cause-and-effect relationship between TB and IAP has not been studied much.

A Secondary Analysis of the Prevalence and Clinical Profile of Psychiatric Referrals of Delirium in a Tertiary Care Hospital in Central India.

Introduction: Delirium is a common and serious neuropsychiatric syndrome characterized by acute, fluctuating alterations in consciousness, cognition, and perception. It is associated with increased morbidity, mortality, length of hospital stays, and healthcare costs.

Aim:  The aim of this study was to assess the prevalence and clinical profile of psychiatric referrals of delirium in a tertiary-care hospital.

Stenotrophomonas maltophilia sepsis in preterm neonates.

, an environmentally ubiquitous microbe, is a challenging opportunistic pathogen in the hospital setting. Neonates are particularly vulnerable to infection with but information on presentation, therapeutic response and outcome of such infection in this population is limited. To expand this knowledge, we report here a series of five cases.

Managing Hereditary Angioedema in a Three-Generation Family: Danazol's Promise in Resource-Limited Settings.

Background Hereditary angioedema (HAE) is a rare disorder in India, and while prevalence data is limited, it is believed that a significant number of individuals may be affected. Due to restricted access to first-line treatments, older therapies like danazol are commonly used despite associated risks in resource-constrained settings. This study aimed to assess the efficacy of danazol as an affordable long-term prophylaxis (LTP) for HAE in a three-generation family.

Radiographic Evaluation of the Prevalence of External Root Resorption in Patients With Periodontitis in Indore: A Cross-Sectional Study.

Objective Permanent teeth roots undergo resorption under pathologic conditions such as trauma, orthodontic treatment, pulpal infections, periodontitis, and periodontal therapy. The present study aimed to determine the prevalence of external root resorption (ERR) in patients with periodontitis as seen in orthopantomography (OPGs). Methodology This single-center, retrospective, cross-sectional radiographic study was conducted from January 2021 to December 2022, including 656 orthopantomographs (OPGs) from patients with periodontitis.

Prevalence of economic violence among the geriatric population and their knowledge and utilization of social security schemes in Chengalpattu district, Tamil Nadu.

Context: Economic independence is an important factor in the prevention of violence among the elderly. Optimal utilization of various social security schemes in India helps them in achieving financial independence and proper utilization of health care services. However, there is a knowledge and service utilization gap among the elderly in our population.

Diagnostic accuracy of Gorelick 10 point scale in comparison to IMCI scale in identifying significant dehydration in South Indian children? - A prospective observational study.

Background: Unavoidable cause of mortality among under 5 children in India is dehydration resulting from acute diarrhoeal diseases. In spite of various dehydration scales available across the world, the most commonly used dehydration scale in India is IMCI. Gorelick 10 point scale having more clinical indicators could also be considered using if the diagnostic accuracy of the scale in identifying the significant dehydration is in par with that of IMCI scale.

Corneal endothelial cell loss with different techniques of nucleus delivery in Manual Small Incision Cataract Surgery- Randomized Controlled Trial.

Purpose: To compare corneal endothelial loss in manual small incision cataract surgery (MSICS) following three different techniques of nucleus delivery (Viscoexpression, Irrigating Vectis, Phacosandwich).

Setting: Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

Design: Prospective, single blinded, randomized controlled trial.

Climate change and contagion: the emerging threat of zoonotic diseases in Africa.

This article investigates the escalating occurrence of zoonotic diseases in Africa, attributing their spread to climate change and human activities. Africa's unique combination of biodiversity, reliance on animal husbandry, and swift urbanization heightens its susceptibility. Climate change disrupts ecosystems and animal habitats, intensifying human-wildlife interactions.

Management of Antenatal Agitation in a Tertiary Care Center in Central India: A Secondary Analysis.

Background The presence of psychiatric symptoms in pregnancy is a common occurrence that requires swift and effective management to avoid harm to self, caregivers, staff, and, above all, the reliant fetus. However, there is a dearth of knowledge, practical guidelines, and research in the context of managing agitated states of antenatal patients. To bridge this critical knowledge gap, this research endeavors to illuminate the practices surrounding the management of agitated pregnant women with respect to psychiatric emergencies in a tertiary care hospital.

A Rare Case of Lipoid Proteinosis in a Patient Presenting With Seizures: A Case Report and Literature Review.

Lipoid proteinosis is a rare genetic disorder affecting the skin, mucous membranes, and central nervous system. Here, we present the case of a 35-year-old female who presented with two episodes of seizures followed by loss of consciousness and injury to the nose. A CT scan and MRI of the brain revealed small symmetrical calcifications in the bilateral medial temporal lobes, a finding highly suggestive of lipoid proteinosis.

Factors associated with help-seeking by women facing intimate partner violence in India: findings from National Family Health Survey-5 (2019-2021).

Background: Intimate partner violence (IPV) against women has harmful effects on their psychological and physical health. However, help-seeking for IPV is significantly low among women in the Indian context. This study examines the different factors that influence help-seeking behaviour among women in India.