Fatal acute uterine inversion post-vaginal delivery: an autopsy-based case report.

Uterine inversion refers to the condition where the fundus is turned inside and positioned within the uterine cavity. Uterine inversion is a life-threatening and uncommon obstetric emergency that can be fatal because of postpartum hemorrhage and shock. Acute uterine inversion is the most common type, which occurs within 24 h of delivery and is usually associated with untrained birth attendants and a lack of knowledge of labor-inducing drugs.

Clinical and Dermoscopic Evaluation of Patients With Topical Steroid Damaged Faces (TSDF).

Background Topical steroid-dependent or damaged face (TSDF) is a common condition where the widespread availability of over-the-counter topical corticosteroid (TCS)-containing products leads to their misuse and addiction. Prolonged use of these steroids on the face can result in significant side effects. Early diagnosis and cessation of steroid use are important.

Clinical and Dermoscopic Evaluation of Periorbital Melanosis and Its Psychological Impact and Effect on Quality of Life: A Descriptive Study.

Introduction: Periorbital melanosis (POM) is a poorly defined condition that is becoming an increasing aesthetic concern. With its multifactorial origin, it necessitates a thorough assessment of targeted multimodal treatments. The psychological impact and underlying pathogenesis have been underexplored, as evidenced by the gap between the roughly 100 indexed articles and the 150 million search engine results on treatments for dark circles.

Exploring Public Interest in Multiple Sclerosis and Its Treatment Measures in the United States: A Google Trends Analysis.

Introduction Multiple sclerosis (MS) afflicts over 2.8 million individuals worldwide and is a leading cause of neurological impairment in young adults. This study investigates the public interest in MS and its treatment options in the United States over the past decade, utilizing Google Trends data.

Correction: The Impact of Microbiome Interventions on the Progression and Severity of Inflammatory Bowel Disease: A Systematic Review.

[This corrects the article DOI: 10.7759/cureus.60786.

Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives.

Gastrointestinal cancer is a malignant condition of the gastrointestinal tract (GI) which affect multi-organs of digestive system, such as esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus. Gastrointestinal cancer is a 5th most common malignant cancer and 4th major cause in cancer-related mortality rate. Various significant facilities are available that have reduced the radio-resistance, chemo-resistance, and their adverse side effects.

A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent.

Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy against breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction of apoptosis, and suppressing angiogenesis, positioning it as a versatile, multitargeted therapeutic tool against cancer.

Optimal use of once-weekly basal insulin efsitora alfa in type 1 and type 2 diabetes: A systematic review and meta-analysis.

Objective: No meta-analysis has holistically analyzed and summarized the efficacy and safety of the novel once-weekly basal insulin efsitora alfa in managing type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods: Clinical trials involving subjects with T1D and T2D receiving once-weekly efsitora alfa in the intervention arm and once-daily basal insulins in the control arm were searched throughout the electronic databases. The primary outcome assessed was the change from baseline in HbA1c.

Exploring Tractography: An Analysis of Brain Connectivity Patterns in Men.

Introduction:  White matter tracts that connect different parts of the brain comprise the structural connectome, which is essential to its operation. Assessing behavioral changes and brain health requires an understanding of these tracts. Diffusion tensor imaging (DTI), in particular, allows for the thorough viewing and characterization of these routes in tractography.

The role of ACE inhibitors and ARBs in preserving cognitive function via hypertension Management: A critical Update.

Hypertension poses a significant risk to cognition-related disorders like dementia. As the global population ages, age-related neurological illnesses such as Alzheimer's disease are becoming increasingly prevalent. The primary hypertension treatments, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors, exhibit neuroprotective properties.

Peak Inspiratory Flow Rate as a Prerequisite for Prescription of Inhaler Devices: A Cross-sectional Study.

Inhaler therapy has become the mainstay of treatment in obstructive airway diseases. Although patients, and to a certain extent doctors also, were not initially comfortable with inhalation devices, they have now become the standard of care in chronic obstructive pulmonary disease (COPD) and asthma. However, the choice of inhaler device prescribed in different subsets of patients is still not clear.

Tuberculous Tenosynovitis of the Wrist: A Rare Case Report.

Introduction: Tuberculosis (TB) of the wrist joint is a rare presentation of extrapulmonary TB, accounting for about 1% of musculoskeletal TB cases. We present a case of wrist joint TB in a 15-year-old immunocompetent male patient.

Case Report: A 15-year-old boy presented with 6-month history of left wrist swelling and pain along with constitutional symptoms for 2 months.

Estimation of HbA1c Levels in Transfusion-Dependent Thalassemia Patients in Comparison With Normal Healthy Individuals.

Introduction HbA1c values used for diagnosing and treating diabetes can be affected by factors such as red blood cell lifespan, hemolysis, red cell transfusion, and the presence of minor Hb species like HbA2 and HBF in hemoglobinopathies like sickle cell disease, homozygous HbC disease, HbSC disease, and β-thalassemia. This study aims to compare HbA1c levels in transfusion-dependent thalassemia (TDT) patients and healthy individuals. Materials and methods This is a cross-sectional comparative study.

LncRNAs SOX2-OT and NEAT1 act as a potential biomarker for esophageal squamous cell carcinoma.

Despite strides in diagnostic and therapeutic approaches for ESCC, patient survival rates remain relatively low. Recent studies highlight the pivotal role of long non-coding RNAs (lncRNAs) in regulating diverse cellular activities in humans. Dysregulated lncRNAs have emerged as potential diagnostic indicators across various cancers, including ESCC.

Segmental Absence of Intestinal Musculature: An Enticing Predicament.

Segmental absence of intestinal musculature (SAIM) was first identified as a cause of intestinal perforation and remains difficult to diagnose clinically. Diagnosing SAIM preoperatively can be difficult; however, detection during the surgical procedure may be feasible if gross observations reveal bowel alterations such as a thinned-out wall, signs of gangrenous changes, or adjacent bowel dilatation. A final diagnosis can be made with the help of histopathology, making it a gold standard.

How Safe is Nd: YAG Laser Capsulotomy in Patients with Uveitis? Outcomes of a Long-Term Study.

Purpose: To study the outcomes and complications of Nd: YAG laser capsulotomy in patients with uveitis.

Methods: This study retrospectively evaluated outcomes of Nd: YAG laser capsulotomy in 260 eyes of 260 patients with uveitis. The main indications for performing capsulotomy were a visually significant posterior capsule opacification (PCO) and inability to visualize the posterior segment.

Papillary muscles: morphological differences and their clinical correlations.

The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed.

Navigating the Role of Surgery in Optimizing Patient Outcomes in Traumatic Brain Injuries (TBIs): A Comprehensive Review.

Traumatic brain injuries (TBIs) present with symptoms ranging from a mildly altered level of consciousness to irreversible coma and death. The most severe stage of TBIs is diffuse axonal injury and swelling affecting the whole brain. Management strategies are based on the classification of TBIs by severity and type and range from cognitive therapy sessions to complex surgeries.

Insights on therapeutic approaches of natural anti-Alzheimer's agents in the management of Alzheimer's disease: A future perspective.

In the current scenario, Alzheimer's disease is a complex, challenging, and arduous health issue, and its prevalence, together with comorbidities, is accelerating around the universe. Alzheimer's disease is becoming a primary concern that significantly impacts an individual's status in life. The traditional treatment of Alzheimer's disease includes some synthetic drugs, which have numerous dangerous side effects, a high risk of recurrence, lower bioavailability, and limited treatment.