Stationary Scholars: The Looming Health Crisis Among Preclinical and Paraclinical Doctors in India.

This letter highlights the critical issue of sedentary lifestyles among preclinical and paraclinical doctors in India, which poses significant health risks that are often overlooked. This manuscript reviews research demonstrating the links between prolonged sitting and increased risks of cardiovascular disease, musculoskeletal disorders, mental health issues, and impaired cognitive function in this population. The COVID-19 pandemic is also discussed as a factor that may have exacerbated sedentary behavior.

Spontaneous multiple keloids: a case report.

An aberrant healing reaction to cutaneous injury or inflammation that spreads outside the original wound's boundaries causes keloidal scars. We present the case of a sixty-year-old male patient who initially came with complaints of respiratory system but had spontaneous lesions over his body for 50 years which remained undiagnosed. It was confirmed on histological examination to be keloids.

Facilitating Seamless Integration of Game-based Assessments in Medical Education.

A health-care professional is expected to hone multiple skills that are not limited to possessing medical knowledge and clinical skills. Game-based assessments are an innovative type of assessment method that combines the features of gamification and simulation to revolutionize the delivery of medical education. These assessments have the potential to promote active engagement of students by ensuring sustained interest, which is not possible to accomplish with conventional assessments.

A homozygous TARS2 variant is a novel cause of syndromic neonatal diabetes.

Aims: Neonatal diabetes is a monogenic condition which can be the presenting feature of complex syndromes. The aim of this study was to identify novel genetic causes of neonatal diabetes with neurological features including developmental delay and epilepsy.

Methods: We performed genome sequencing in 27 individuals with neonatal diabetes plus epilepsy and/or developmental delay of unknown genetic cause.

Comparison of the efficacy of aescin and diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C-reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial.

Introduction: Surgical removal of an impacted third molar is one of the most common oral surgical procedures performed in dental offices. The postoperative phase is often associated with severe inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are usually prescribed to manage postoperative discomfort.

Amend the Mental Health Care Act 2017: A Survey of Indian Psychiatrists (Paper 1).

Aim: This paper highlights the difficulties and lacunae in the Mental Health Care Act 2017 that hinder its implementation and use for the care and treatment of persons with mental illness in India.

Methods: An online nationwide survey, involving structured questions as well as open-ended questions, to elicit the level of implementation, experience in complying with the provisions of the Act, and level of satisfaction, of practicing psychiatrists was carried out. Responses were analyzed using appropriate statistics.

Exploring Computational Advancements in ADME: Essential Insights for Drug Disposition.

The physicochemical properties of the physiological makeup and the chemical componentof the system make this challenging throughout strenuous procedure. The current review concentrated on in silico modelling of drug disposition, involving absorption process, distribution process, and excretion process and includes thorough knowledge of various database expeditions, the development of a pharmacophore model, molecular docking studies, homology modelling supported sequence similarity and quantitative structure-activity relationships (QSAR)/ quantitative structure-property relationships (QSPR) evaluation along with all information about drug movement and related computational tools for understanding potential chemical and pathophysiological changes. The primary development in ADMET modeling in current times has been the clarification of the function and effective modeling of various transporters.

COVID-19 in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): a propensity matched analysis (2020-2021).

Background: By 2023, COVID-19 had caused 6.8 million deaths in the United States. COVID-19 presents more severely in leukemia compared to solid tumors (OR 1.

Risk of cognitive decline among patients with dengue virus infection: a systematic review.

Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion.

Dr. Ravindra Kolhe and Dr. Smita Kolhe: The Pioneers of Improving Tribal Healthcare in Maharashtra, India.

Dr. Ravindra Kolhe and Dr. Smita Kolhe are the pioneers of improving tribal healthcare in Maharashtra, dedicating more than three and a half decades of their lives for the sake of the people in the remote Bairagarh village of the Melghat area.

AI in Clinical Trials and Drug Development: Challenges and Potential Advancements.

Artificial intelligence (AI) is one of the fastest-growing fields in various industries, including engineering, architecture, medical and clinical research, aerospace, and others. AI, which is a combination of machine learning (ML), deep learning (DL), and human intelligence (HI), is revolutionizing drug discovery and development by making it more cost-effective and efficient. It is also being used in fields such as medicinal chemistry, molecular and cell biology, pharmacology, pharmacokinetics, formulation development, and toxicology.

Real World Outcomes with Treatment Free Remission in Chronic Myeloid Leukemia-Experience from a Tertiary Care Cancer Centre.

Chronic myeloid leukaemia (CML) is caused by balanced translocation t(9::22)(q34;q11) resulting in formation of pathogenic BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML. Ongoing treatment with TKI leads to side effects and has financial impact.

Efficacy and safety of stem cell therapy for fistula management: an overview of existing systematic reviews.

Background: Fistulas, abnormal connections between two anatomical structures, significantly impact the quality of life and can result from a variety of causes, including congenital defects, inflammatory conditions, and surgical complications. Stem cell therapy has emerged as a promising alternative due to its potential for regenerative and immunomodulatory effects. This overview of systematic reviews aimed to assess the safety and efficacy of stem cell therapy in managing fistulas, drawing on the evidence available.

Community noise mapping: The need, identified challenges, and potential solutions.

Hearing loss and deafness have been globally recognized as one of the major public health concerns that need immediate attention. Noise mapping refers to the systematic process of measuring and visualizing the noise level distribution in a well-defined location, preferably in urban settings or industrial areas. This exercise of noise mapping is generally done with the intention of identifying the noise hotspots and measuring the extent of exposure to noise levels in different areas.

Factors affecting early initiation of breastfeeding among mothers of urban area of Jabalpur district, Madhya Pradesh, India: A community-based cross-sectional study.

Background: Early initiation of breastfeeding reduces infant mortality and morbidity and prolongs the duration of breastfeeding.

Objective: The present study was conducted to assess the prevalence of early initiation of breastfeeding and factors associated with early initiation of breastfeeding in the urban area of Jabalpur district of Madhya Pradesh.

Methodology: The present community-based cross-sectional study was conducted in an urban area of Jabalpur district of Madhya Pradesh from March 2017 to July 2018 on 370 recently delivered mothers.

From Awareness to Action: Addressing Folic Acid Supplementation in Western India Among Women of Reproductive Age.

Background Folate, a vitamin B9, can be sourced naturally in the diet or the form of supplements. Studies highlight the prevention of neural tube abnormalities in women of reproductive age. To prevent these, low daily doses of FA (400-800 μg) are recommended for all women planning pregnancy, with higher doses for those with previous NTD-affected pregnancies.

The silent spread: why we need increased awareness of Crimean-Congo haemorrhagic fever.

Crimean-Congo Hemorrhagic Fever (CCHF) presents significant global health challenges, highlighted by its sporadic nature and high fatality rates. The manuscript emphasizes the disease's tendency to be under-recognized and the diagnostic challenges it poses, often mimicking other illnesses and leading to frequent misdiagnosis. There is a noted absence of robust diagnostic tools, specific treatments, or vaccines, leaving only supportive care generally available.