33 results match your criteria: "Macular Edema Pseudophakic Irvine-Gass"
Cystoid macular edema after vitrectomy and after phacovitrectomy for epiretinal membrane.
Can J Ophthalmol
October 2024
Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA. Electronic address:
Article Synopsis
- The study aimed to compare the rates of cystoid macular edema (CME) in patients who underwent vitrectomy versus phacovitrectomy for the removal of epiretinal membranes (ERMs).
- Researchers reviewed medical records of patients operated on by the same surgeon, categorizing them based on whether they had natural lenses (phakic) or artificial lenses (pseudophakic).
- Results showed that 15.4% of patients in the phacovitrectomy group experienced increased macular thickness (a sign of CME) compared to just 3.8% in the vitrectomy group, suggesting that the removal of the crystalline lens may trigger greater risk of CME.
Correlation between Severity of Idiopathic Epiretinal Membrane and Irvine-Gass Syndrome.
J Pers Med
August 2023
Department of Ophthalmology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
A higher risk of pseudophakic cystoid macular edema (PCME) has been reported in patients with preoperative idiopathic epiretinal membrane (ERM); however, whether the formation of PCME depends on the grade of ERM has not been well established. We conducted a retrospective case-control study of 87 eyes of 78 patients who were preoperatively diagnosed with idiopathic ERM and had undergone cataract surgery. Patients were divided into two groups: PCME and non-PCME groups.
View Article and Find Full Text PDFSafety and Efficacy of Prostaglandin Analogues in the Immediate Postoperative Period after Uneventful Phacoemulsification.
Vision (Basel)
June 2023
Department of Ophthalmology, General Hospital Papageorgiou, 56429 Thessaloniki, Greece.
Prostaglandin analogues (PGAs) have been associated with the development of pseudophakic macular edema (PME) in complicated cataract cases, but evidence on their effects in uncomplicated phacoemulsification remains controversial. This two-arm, prospective, randomised study included patients with glaucoma or ocular hypertension under PGA monotherapy who were scheduled for cataract surgery. The first group continued PGA use (PGA-on), while the second discontinued PGAs for the first postoperative month and reinitiated use afterwards (PGA-off).
View Article and Find Full Text PDFCystoid Macular Edema after Cataract Surgery in the United States: IRIS® Registry (Intelligent Research in Sight) Analysis.
Ophthalmology
October 2023
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:
Article Synopsis
- A study analyzed the incidence, risk factors, and visual outcomes of cystoid macular edema (CME) following cataract surgery in the U.S. from 2016 to 2019, using data from over 3 million surgeries.
- Of the patients, 0.8% were diagnosed with CME within 90 days post-surgery, with higher incidence associated with being male, under 65, Black, and having diabetes-related eye conditions.
- The presence of CME significantly impacted visual outcomes, with affected patients more likely to have worse vision (average 20/30) compared to those without CME (average 20/25) at 12 months post-surgery.
SUSTAINED-RELEASE LOW-DOSE FLUOCINOLONE ACETONIDE INTRAVITREAL IMPLANT FOR CHRONIC POSTOPERATIVE CYSTOID MACULAR EDEMA: TWO CASE REPORTS.
Retin Cases Brief Rep
July 2024
The Eye Associates Department of Ophthalmology, Sarasota Memorial Hospital, Sarasota, Florida.
Article Synopsis
- Two patients with chronic postoperative cystoid macular edema (CME) associated with noninfectious posterior uveitis had limited success with traditional corticosteroid treatments and were instead given a fluocinolone 0.18-mg implant.
- Chronic postoperative CME, common after cataract surgery, affects 0.1% to 2% of patients and is often difficult to manage with standard therapies that require frequent dosing.
- After treatment with the fluocinolone implant, both patients showed significant improvement in symptoms, visual acuity, and reduced macular edema over the course of several months.
Spontaneous closure of a chronic full-thickness idiopathic macular hole after Irvine-Gass syndrome resolution.
BMC Ophthalmol
March 2022
Department of Ophthalmology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
Article Synopsis
- A 75-year-old woman experienced decreased vision and was diagnosed with a full-thickness idiopathic macular hole (IMH) in her left eye and cataracts in both eyes.
- After successfully undergoing cataract surgery, she developed Irvine-Gass syndrome, which contributed to visual disturbances.
- Remarkably, the IMH closed on its own after the Irvine-Gass syndrome resolved, suggesting a possible connection between cyst formation and the healing of the macular hole.
Topical NSAIDs, intravitreal dexamethasone and peribulbar triamcinolone for pseudophakic macular edema.
BMC Ophthalmol
November 2021
Ophthalmology department, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907. Hospitalet de Llobregat, Barcelona, Spain.
Article Synopsis
- * After 2 months of using topical NSAIDs, significant improvements were observed in visual acuity and retinal thickness, with resolution occurring in 58% of cases; those not responding were treated with corticosteroids.
- * The treatment protocol showed an overall success rate of over 80%, marking a significant finding for managing PME, and introduced new insights into choroidal thickness using advanced imaging technology.
Current Management Options in Irvine-Gass Syndrome: A Systemized Review.
J Clin Med
September 2021
Dobry Wzrok Ophthalmological Clinic, Kliniczna 1B/2, 80-402 Gdansk, Poland.
Article Synopsis
- Irvine-Gass syndrome (IGS) is a common complication after cataract surgery, usually leading to benign, self-limiting macular edema (ME) that often doesn’t impair vision, but some cases may become persistent and affect visual function.
- Research found 28 relevant studies since 2000 on treating cystoid macular edema (CME), but only 7 were randomized clinical trials, highlighting the lack of solid treatment guidelines for IGS.
- Current recommendations suggest using topical non-steroidal anti-inflammatory drugs (NSAIDs) as the first-line treatment, with more invasive options considered for severe cases; further investigation is needed on newer treatments like subthreshold micropulse laser (SML) and the effects of early
Topical interferon - A novel treatment for pseudophakic macular edema.
Indian J Ophthalmol
September 2021
Department of Refractive Surgeries, Narayana Nethralaya, Bangalore, Karnataka, India.
Article Synopsis
- The study evaluated the effectiveness of topical interferon (IFN) therapy as a treatment for pseudophakic cystoid macular edema (P-CME) compared to conventional treatments like steroids and antivascular growth factors.
- Eight patients were assessed, showing a significant decrease in central macular thickness (CMT) from an average of 560.1 μm to 344.33 μm after 4 weeks of IFN therapy.
- Topical IFN was found to be a safe, noninvasive, and cost-effective treatment option, especially beneficial in cases with posterior capsular rent and when steroids are not suitable.
Fluocinolone Acetonide 0.19 mg Implant in Patients with Cystoid Macular Edema Due To Irvine-Gass Syndrome.
Int Med Case Rep J
February 2021
Serviço de Oftalmologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal.
Background: Cystoid macular edema (CME) due to Irvine-Gass syndrome (IGS) is one of the common causes of painless visual impairment post-cataract extraction. The treatment of recurrent cases remains unstandardized.
Objective: To evaluate the effectiveness and safety of fluocinolone acetonide intravitreal implant (0.
Comparison of intravitreal anti-vascular endothelial growth factor agents and treatment results in Irvine-Gass syndrome.
Int J Ophthalmol
October 2020
Department of Ophthalmology, Izmir Katip Çelebi University Atatürk Educating and Research Hospital, Izmir 35620, Turkey.
Article Synopsis
- The study aims to compare the effectiveness of three anti-VEGF treatments—bevacizumab, ranibizumab, and aflibercept—on patients with pseudophakic cystoid macular edema (CME) due to Irvine-Gass syndrome (IGS).
- A retrospective case series was conducted on 59 patients, analyzing various eye measurements at baseline and over six months to assess treatment outcomes.
- While all treatments showed efficacy, bevacizumab exhibited a faster resolution time for CME and was suggested to be more cost-effective compared to the other two agents.
Anti-interleukin-6 receptor therapy with tocilizumab for refractory pseudophakic cystoid macular edema.
Am J Ophthalmol Case Rep
December 2020
Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Article Synopsis
- The case study details a clinical situation involving an 80-year-old man with refractory cystoid macular edema (CME) post-cataract surgery, exhibiting previous conditions like glaucoma and iritis.
- Initial treatments with topical prednisolone and oral acetazolamide showed temporary improvement but were ineffective long-term, leading to worsening visual acuity and increased fluid in the macula after discontinuation of systemic acetazolamide due to side effects.
- Ultimately, the patient was treated with monthly infusions of tocilizumab, an anti-interleukin-6 receptor antagonist, indicating a potential new therapeutic option for resistant CME cases.
Alterations of the foveal central bouquet associated with cystoid macular edema.
Can J Ophthalmol
August 2020
Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA; Greater Los Angeles VA Healthcare Center, Los Angeles, CA. Electronic address:
Article Synopsis
- The study focused on the central bouquet (CB) of the fovea, exploring how cystoid macular edema (CME) from various causes affects visual outcomes and structural changes in the eye.
- Using spectral-domain optical coherence tomography (SD-OCT) on 61 patients, researchers classified CB alterations and noted significant correlations between these changes and factors like central macular thickness and visual acuity.
- Results indicated that CB alterations were prevalent in cases of uveitis and central retinal vein occlusion, and these changes might result from mechanical stress on Müller cells caused by the swelling associated with CME.
Ozurdex for refractory macular edema secondary to diabetes, vein occlusion, uveitis and pseudophakia.
Can J Ophthalmol
October 2019
Department of Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, B.C.
Article Synopsis
- * Out of 144 patient charts reviewed, 100 eyes met the criteria, showing improved central retinal thickness (CRT) particularly in diabetic macular edema and posterior noninfectious uveitis, while visual acuity improvements were noted but not statistically significant.
- * The findings indicated that the implant is generally safe and can lead to better anatomical outcomes, but improvements in retinal structure don’t always translate to better vision, emphasizing the importance of early
The Efficacy of Posterior Subtenon Triamcinolone Acetonide Injection in Treatment of Irvine-Gass Syndrome.
Ocul Immunol Inflamm
May 2020
Retina Department, Okmeydanı Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Article Synopsis
- * The results showed a significant decrease in central macular thickness over six months, alongside improvements in best corrected visual acuity (BCVA) at all follow-up visits.
- * The mean intraocular pressure (IOP) remained stable, indicating that PST injection is both an effective and safe treatment for this condition.
Interferon Alpha for Refractory Pseudophakic Cystoid Macular Edema (Irvine-Gass Syndrome).
Ocul Immunol Inflamm
January 2021
Centre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of interferon alpha-2a (IFN) in treating patients with refractory pseudophakic cystoid macular edema (PCME).
- A group of 20 patients was analyzed, showing a significant reduction in central retinal thickness (CRT) from an average of 513 µm to 190 µm after treatment.
- Additionally, best-corrected visual acuity (BCVA) improved in 75% of the eyes, and no major side effects from the treatment were reported, indicating that IFN is a highly effective option for this condition.
Comparison of topical nepafenac 0.1% with intravitreal dexamethasone implant for the treatment of Irvine-Gass syndrome.
Int J Ophthalmol
February 2019
Department of Opthalmology, Trakya University, Faculty of Medicine, Edirne 22030, Turkey.
Article Synopsis
- The study aimed to compare the safety and effectiveness of intravitreal dexamethasone (IVD) compared to topical nepafenac (TN) for treating previously untreated Irvine-Gass syndrome (IGS) in patients after cataract surgery.
- It was a retrospective analysis of 62 eyes, with various assessments like visual acuity and eye pressure conducted at baseline and after 1, 3, and 6 months of treatment.
- Results showed that the IVD group had better visual acuity and lower central macular thickness compared to the TN group, indicating IVD is more effective for managing pseudophakic macular edema despite similar intraocular pressure readings between the two treatments after 6 months.
Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography.
Eur J Ophthalmol
March 2018
1 Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil - France.
Article Synopsis
- - The study aimed to compare findings from optical coherence tomography angiography (OCT-A) of the superficial and deep capillary plexuses in eyes with pseudophakic cystoid macular edema (PCME) against those from fluorescein angiography and spectral-domain optical coherence tomography.
- - Thirteen eyes with PCME underwent various eye examinations, and their vascular densities were measured and compared to those of 46 healthy eyes, revealing significantly lower vascular density in both capillary plexuses for the PCME group.
- - The conclusion highlights the potential of OCT-A for effectively assessing retinal blood flow in PCME, which could aid in understanding the underlying mechanisms of this condition.
USE OF AFLIBERCEPT FOR THE MANAGEMENT OF REFRACTORY PSEUDOPHAKIC MACULAR EDEMA IN IRVINE-GASS SYNDROME AND LITERATURE REVIEW.
Retin Cases Brief Rep
February 2018
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Article Synopsis
- An 83-year-old woman experienced vision issues from pseudophakic cystoid macular edema after cataract surgery and struggled to improve with initial treatments.
- After trying other medications without success, she saw improvement following one injection of intravitreal aflibercept, but she faced recurrence after two months.
- Although three additional monthly injections were also effective, the patient chose not to continue treatment after the recurrence.
Anterior chamber migration of dexamethasone intravitreal implant (Ozurdex®) through basal iridectomy (Ando) in a pseudophakic patient.
Eur J Ophthalmol
April 2016
Department of Ophthalmology, Faculty of Medicine University Vita-Salute San Raffaele in Milan and University Hospital San Raffaele in Milan, Milan - Italy.
Article Synopsis
- - The text discusses a case where a dexamethasone implant (Ozurdex®) used for treating macular edema migrated into the front part of the eye (anterior chamber) in a pseudophakic patient after a specific eye surgery (basal iridectomy).
- - A pseudophakic patient is someone who has a replaced lens due to cataract surgery, and in this case, they developed complications like corneal swelling (edema) and increased eye pressure due to the implant migration.
- - The findings suggest that certain patients who have undergone previous eye surgeries, especially those with basal iridectomy, are particularly vulnerable to this type of implant migration.
Dexamethasone implant as an effective treatment option for macular edema due to Irvine-Gass syndrome.
J Cataract Refract Surg
September 2015
From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
Article Synopsis
- - The study aimed to evaluate the safety and effectiveness of Ozurdex, a dexamethasone implant, for treating pseudophakic macular edema following cataract surgery.
- - Conducted at Ludwig-Maximilians-University Munich, the research included 23 patients and measured visual acuity, foveal thickness, and retinal sensitivity over a year.
- - Results showed significant improvements in visual acuity and reduction in foveal thickness, with no major side effects reported, indicating the treatment’s overall safety and efficacy.
A Case of Acute Bilateral Irvine-Gass Syndrome following Uncomplicated Phacoemulsification, Demonstrated with Optical Coherence Tomography.
Case Rep Ophthalmol
June 2015
Parke Street Specialist Centre, Katoomba, N.S.W., Australia.
Article Synopsis
- A case study reports on an 82-year-old man who developed acute bilateral Irvine-Gass syndrome (CME) after undergoing cataract surgery on both eyes.
- The patient experienced cystoid macular edema in his left eye 25 days post-surgery, which was treated and resolved completely; however, he later developed CME in his right eye despite preventive measures.
- The findings highlight the necessity of considering Irvine-Gass syndrome as a potential cause of blurred vision following cataract surgery, emphasizing the need for patient counseling about the associated risks for the other eye.
Longitudinal analysis of the structural pattern of pseudophakic cystoid macular edema using multimodal imaging.
Graefes Arch Clin Exp Ophthalmol
January 2016
Division of Retina and Vitreous, Ophthalmic Consultants of Long Island, 2000 North Village Avenue, suite 402, Rockville Centre, NY, 11570, USA.
Article Synopsis
- The study investigates how pseudophakic cystoid macular edema (CME) evolves and its correlation with retinal changes detected through imaging techniques like SD-OCT and fluorescein angiography.
- It involves a detailed analysis of 39 patients over 6 months, focusing on structural features such as cystic changes in the inner nuclear layer (INL) and outer plexiform layer (OPL), and the effects of treatment with glucocorticoids.
- Findings suggest that CME progresses from INL changes to combined INL and OPL involvement, often involving subretinal fluid, indicating disease activity, particularly within the early postoperative period.
[Study of the effect of intravitreal dexamethasone implant in pseudophakic macular edema. Preliminary].
Arch Soc Esp Oftalmol
July 2015
Servicio de Oftalmología, Hospital Universitario de La Ribera, Alzira, Valencia, España.
Article Synopsis
- The study aimed to assess the effectiveness of intravitreal dexamethasone implants in treating pseudophakic macular edema (PME) in four patients.
- Results showed that macular thickness significantly decreased from an average of 414μm to 330.25μm after one month, alongside an improvement in best-corrected visual acuity from 0.3 to 0.575.
- The treatment's effects lasted around 3.5 months, suggesting that dexamethasone implants may be a viable option for managing Irvine-Gass syndrome.
[Efficacy of intravitreal dexamethasone implants in macular edema excluding venous occlusions: results for a cohort of 80 patients].
J Fr Ophtalmol
February 2015
Centre hospitalier national ophtalmologique des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
Article Synopsis
- The study investigates the effectiveness of the intravitreal dexamethasone implant for treating various types of diffuse macular edema (ME) with inflammatory causes, outside of typical cases like retinal venous occlusions or non-infectious uveitis.
- Conducted over two years with 80 patients included, the primary focus was on how visual acuity changed after the treatment, and results showed significant improvements across several conditions.
- Findings indicate a mean visual acuity improvement of 6.7 letters for diabetic ME, 9.6 letters for ME post-retinal detachment, and 15.2 letters for Irvine-Gass syndrome, suggesting the implant is an effective second-line treatment option with a median duration of efficacy