10 results match your criteria: "Macquarie University Medical School[Affiliation]"
Article Synopsis
- - This study investigates which models of vascular afterload best predict right-sided heart dysfunction in patients with newly diagnosed pulmonary hypertension (PH), focusing on factors like pulmonary vascular resistance (PVR) and pulmonary arterial compliance (PAC).
- - Researchers analyzed data from 86 patients using right-sided heart catheterization and cardiac magnetic resonance imaging, revealing that PVR was the most accurate predictor for several measures of heart dysfunction, except when PVR was low, where PAC showed better predictive power.
- - A combined model using PVR, PAC, and characteristic impedance provided the best prediction for right atrial volume changes, and a specific PAC threshold (<2.3 mL/mm Hg) was identified as a strong predictor for right-sided heart dysfunction in
Systematic Review of Preoperative Prognostic Biomarkers in Perihilar Cholangiocarcinoma.
Cancers (Basel)
February 2024
Department of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Article Synopsis
- Perihilar cholangiocarcinoma (pCCA) is a rare and aggressive cancer type, with surgery being the main treatment option, but it comes with high risks and low survival rates.
- This systematic review aimed to find preoperative biomarkers that could predict survival outcomes post-surgery for pCCA by analyzing studies from various databases.
- The review identified 64 biomarkers linked to survival, such as raised CA19-9 and low serum albumin, but noted varying cutoff values, highlighting the need for further validation in larger studies and tissue samples.
The latest hypertension guidelines: from encryption to decryption, finally!
J Hypertens
December 2023
University of Texas Southwestern Medical School, Dallas, Texas, USA.
Prognostic role of pulmonary impedance estimation to predict right ventricular dysfunction in pulmonary hypertension.
ESC Heart Fail
June 2023
Department of Cardiology, St Vincent's Hospital, Darlinghurst, Australia.
Background: The effect of pulmonary hypertension (PH) on right ventricular (RV) afterload is commonly defined by elevation of pulmonary artery (PA) pressure or pulmonary vascular resistance (PVR). In humans however, one-third to half of the hydraulic power in the PA is contained in pulsatile components of flow. Pulmonary impedance (Zc) expresses opposition of the PA to pulsatile blood flow.
View Article and Find Full Text PDFComparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure.
Front Cardiovasc Med
April 2022
Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: The aim of this study was to explore the risk of target organ damage (TOD) in different groups based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations.
Methods: The study cohort was divided into four groups according to the status of cfPWV and CBP [Group (): high cfPWV and high CBP; Group (): high cfPWV and normal CBP; Group (): normal cfPWV and high CBP; Group (): normal cfPWV and normal CBP]. TOD was determined by the assessment of carotid intima-media thickness (CIMT) abnormality, chronic kidney disease (CKD), microalbuminuria, and left ventricular hypertrophy (LVH).
Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population.
J Cardiovasc Dev Dis
March 2022
Faculty of Medicine, Health and Human Sciences, Macquarie (University) Medical School, Sydney 2109, Australia.
Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean counterparts. Our study sought to observe any potential association between brachial−ankle pulse wave velocity (BAPWV), a marker of arterial stiffness related to CVD risk, and Body Mass Index (BMI), a crude and widely used measure of obesity.
View Article and Find Full Text PDFRenal denervation therapy for hypertension: all that glitters is not gold.
Eur Heart J
June 2022
Apollo Institute for Blood Pressure Management, World Hypertension League/South Asia Office, Apollo Hospitals, and Apollo Medical College, Hyderabad, India.
Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease.
Sci Rep
February 2020
Sanyal biotechnology, 800 E Leigh St, Richmond, VA, 23219, USA.
There is a need for continued drug development for nonalcoholic steatohepatitis (NASH). Bergamot is a plant whose fruit juice is enriched with flavonoids and phenolic compounds which improves dyslipidemia and markers of systemic inflammation in patients with Metabolic Syndrome. The aim of this study was to perform a preclinical "proof of concept" study of Bergamot polyphenolic formulation (BPF99) for the treatment of NASH.
View Article and Find Full Text PDFHypertension epidemiology in India: emerging aspects.
Curr Opin Cardiol
July 2019
Apollo Institute for Blood Pressure Management, World Hypertension League South Asia Office, Apollo Hospitals and Apollo Medical College, Hyderabad, India.
Purpose Of Review: Hypertension is the most important noncommunicable disease risk factor in India with an estimated burden of 200 million persons. Nationwide studies and meta-analyses have reported increasing prevalence. We summarize unique features of hypertension in India.
View Article and Find Full Text PDFAmerican and European Hypertension Guidelines: Finding Common Ground.
Am J Cardiol
April 2019
University of Texas Southwestern Medical School Dallas, Texas; Apollo Institute for Blood Pressure Management, Apollo Hospitals and Apollo Medical College, Hyderabad, India; Faculty of Medicine and Health Sciences, Macquarie University Medical School, Sydney, Australia.