Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer.

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objectives To identify and estimate the prognostic value of molecular biomarkers as predictors of pathological complete response to neoadjuvant chemoradiotherapy in people with locally advanced rectal cancer. summarises the review question in population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format.

Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay.

Aggregation of β-amyloid protein is a hallmark pathology of the neurodegenerative disorder Alzheimer's disease and proceeds from monomers to insoluble misfolded fibril forms via soluble and highly toxic oligomeric intermediates. Given the dual feature of being the most toxic form of the Aβ aggregate proteome and an early marker of pathogenesis, there is a need for sensitive methods that can be used to detect Aβ oligomers and investigate the dynamics of aggregation. Herein, we describe a method based on the application of an oligomer-sensitive fluorescent chemical probe pTP-TFE combined with the use of a QIAD (Quantitative determination of Interference with Aβ Aggregate Size Distribution) assay to correctly identify Aβ oligomers in high sensitivity.

Reporting guidelines for protocols of randomised controlled trials of implantable neurostimulation devices: the SPIRIT-iNeurostim extension.

Background: The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement has improved the quality of reporting of randomised trial protocols. Extensions to the SPIRIT statement are needed to address specific issues of trial protocol reporting, including those relevant to particular types of interventions. Methodological and reporting deficiencies in protocols of clinical trials of implantable neurostimulation devices are common.

Effectiveness of a Novel Multimodal Intervention for Family Caregivers of Persons With Age-Related Macular Degeneration: A Randomized Controlled Trial.

Purpose Age-related macular degeneration (AMD) is a leading cause of visual impairment in older adults. Individuals affected by AMD often require regular physical and emotional support from family caregivers. Carers of people with AMD endure significant physical burdens, emotional distress, increased financial stress, and disruptions due to their lifestyle and retirement plans as a direct consequence of the AMD caregiving experience.

Screening for obstructive sleep apnea in the memory clinic: A comparison of questionnaires, pulse oximetry, and polysomnography.

Background: Obstructive sleep apnea (OSA) is highly prevalent among older adults and has been associated with cognitive decline and dementia risk. The suitability of screening tools for detecting OSA in memory clinic settings is unclear.

Objective: To evaluate the utility and validity of the STOP-Bang questionnaire (SBQ) and pulse oximeter as a screening tool, compared to gold-standard polysomnography (PSG) in older adults attending a memory clinic.

Evaluation of a goalkeeper-specific motor coordination assessment in youth football.

Talent identification and development (TID) in football can be enhanced through objective assessments of talent predictors. Yet, available instruments rarely consider the unique demands of goalkeepers (GKs). During early phases of talent development, considering a GK's giftedness relating to, for example, different abilities (e.

Exploring the use and usability of the Physiotherapy Evidence Database (PEDro) 'Evidence in your inbox' e-mail alert service.

Objective: To evaluate the use and useability of the Physiotherapy Evidence Database's 'Evidence in your inbox' e-mail alert service.

Materials And Methods: An explanatory sequential design consisting of a usage evaluation, cross-sectional survey, and semi-structured interviews. Usage was evaluated using routinely collected data from October 2015 to March 2021: number of subscribers, number of articles, open rates, and click-through rates.

Reporting guidelines for randomised controlled trial reports of implantable neurostimulation devices: the CONSORT-iNeurostim extension.

Background: The Consolidated Standards of Reporting Trials (CONSORT) statement has improved the quality of reporting of randomised trials. Extensions to the CONSORT statement are often needed to address specific issues of trial reporting, including those relevant to particular types of interventions. Methodological and reporting deficiencies in clinical trials of implantable neurostimulation devices are common.

Effectiveness of strategies for implementing guideline-concordant care in low back pain: a systematic review and meta-analysis of randomised controlled trials.

Background: International low back pain guidelines recommend providing education/advice to patients, discouraging routine imaging use, and encouraging judicious prescribing of analgesics. However, practice variation occurs and the effectiveness of implementation strategies to promote guideline-concordant care is unclear. This review aims to comprehensively evaluate the effectiveness of implementation strategies to promote guideline-concordant care for low back pain.

Fossil insect-feeding traces indicate unrecognized evolutionary history and biodiversity on Australia's iconic Eucalyptus.

Fossilized plant-insect herbivore associations provide fundamental information about the assembly of terrestrial communities through geologic time. However, fossil evidence of associations originating in deep time and persisting to the modern day is scarce. We studied the insect herbivore damage found on 284 Eucalyptus frenguelliana leaves from the early Eocene Laguna del Hunco rainforest locality in Argentinean Patagonia and compared damage patterns with those observed on extant, rainforest-associated Eucalyptus species from Australasia (> 10 000 herbarium sheets reviewed).

Priming the distractor can eliminate the Stroop interference effect.

The Stroop interference effect-the slower response to color in an incongruent Stroop stimulus (e.g., ) relative to a neutral Stroop stimulus (e.

Gut microbiota strain richness is species specific and affects engraftment.

Despite the fundamental role of bacterial strain variation in gut microbiota function, the number of unique strains of a species that can stably colonize the human intestine is still unknown for almost all species. Here we determine the strain richness (SR) of common gut species using thousands of sequenced bacterial isolates with paired metagenomes. We show that SR varies across species, is transferable by faecal microbiota transplantation, and is uniquely low in the gut compared with soil and lake environments.

Failure investigation of canned motor pump high temperature at yellow Teikoku Rotary Guardian as circulating pumps on the refining column.

The canned motor pump has a unique design where the motor rotor and pump impeller are mounted on the same shaft, requiring careful balancing of axial and radial forces to ensure reliable operation. The use of a canned motor pump with a floating impeller system helps to balance the axial forces of the impeller, this balance ensures that the impeller is not subjected to excessive axial forces which can lead to premature wear or failure. The purpose of this study is to investigate the axial force on the canned motor pump when overheating occurs due to an operational fault in the distillation column.

What they did next: Using follow-up phone calls to investigate health care access patterns of patients who take their own leave.

Objectives: The purpose of the present study was to use telephone follow-up (TFU) to investigate the actions taken by patients after they took their own leave (TOL) from an ED, with a focus on priority groups who are at risk of experiencing health inequity. These included people experiencing homelessness (EH), people with a low socioeconomic status by index of relative socioeconomic disadvantage (IRSD) and First Nations people. The primary outcome was being seen by a general practitioner (GP) within 2 days of the TOL event.

Online transcranial magnetic stimulation reveals dynamic interactions between language control and processing in bilingual language production.

Language production in bilinguals relies on the collaborative interaction between two neural systems: the language control system (e.g. the right inferior frontal gyrus) and the language processing system (e.

Emotional Intelligence as a Component of Surgical Coaching: A Scoping Review.

Objective: Surgical coaching has become more widespread and involves both technical and nontechnical skills. Emotional Intelligence (EI) is an important nontechnical skill and is associated with leadership skills, increased job satisfaction and superior nontechnical skills. This scoping review aimed to explore the use of EI as a component of surgical coaching.

Association of Abnormal Body Weight and Allergic Rhinitis-A Systematic Review and Meta-Analysis.

Objective: Allergic rhinitis (AR) is a prevalent inflammatory condition of the nasal mucosa, with significant burden worldwide. While studies have demonstrated a relationship between body mass index (BMI) and other atopic diseases, its association with AR is uncertain. This study aims to clarify the association between non-normal BMI and AR.

Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration.

Habitats with intermittent flooding, such as paddy soils, are crucial reservoirs in the global carbon pool; however, the effect of phage-host interactions on the biogeochemical cycling of carbon in paddy soils remains unclear. Hence, this study applied multiomics and global datasets integrated with validation experiments to investigate phage-host community interactions and the potential of phages to impact carbon sequestration in paddy soils. The results demonstrated that paddy soil phages harbor a diverse and abundant repertoire of auxiliary metabolic genes (AMGs) associated with carbon fixation, comprising 23.

Preferences of Individuals With Obesity for Online Medical Consultation in Different Demand Scenarios: Discrete Choice Experiments.

Background: Obesity is a unique chronic disease, with China having the largest number of people living with overweight and obesity in the world. There has been little research from the demand perspective for online medical consultation (OMC) by individuals living with obesity. With the growing demand for obesity OMC, especially due to the emergence of new pharmacotherapies, such as glucagon-like peptide-1 receptor agonists, individuals living with obesity are seeking both advice on obesity management and the prescription of obesity drugs.

An Analysis of Australia's Legal Framework for Access to More Affordable but Unapproved Medicines and Biologics.

Objective: Approved medicines are not always sufficient to address the needs of patients so several legal pathways exist to enable access to unapproved medicines for treatment purposes. This article is the first to provide an in-depth analysis of this regulatory framework that governs access to unapproved medicines in Australia with a specific focus on affordability-motivated access.

Methods: Legislation, regulations, and guidelines were critically analysed to identify the de jure basis for importation and supply of unapproved medicines in Australia.

Paleobotany reframes the fiery debate on Australia's rainforest edges.

The tall eucalypt forests (TEFs) of the Australian tropics are often portrayed as threatened by 'invasive' neighboring rainforests, requiring 'protective' burning. This framing overlooks that Australian rainforests have suffered twice the historical losses of TEFs and ignores the ecological and paleobiological significance of rainforest margins. Early Eocene fossils from Argentina show that biodiverse rainforests with abundant Eucalyptus existed > 50 million years ago (Ma) in West Gondwana, shaped by nonfire disturbance factors such as landslides and volcanic flows.