535 results match your criteria: "Maclean Center for Clinical Medical Ethics[Affiliation]"

Financial Toxicity Has Never Been More Important in Cancer Care: How Do We Measure It?

JCO Oncol Pract

January 2025

University of Chicago Medicine, Department of Medicine, Section of Hematology/Oncology, Maclean Center for Clinical Medical Ethics, Supportive Oncology Program, Chicago, IL.

View Article and Find Full Text PDF

Challenging Conventional Care: Ethical Considerations of De-intensification of Therapy in IBD.

Gastroenterology

December 2024

Department of Medicine, University of Chicago Medicine Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois; The MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois.

View Article and Find Full Text PDF

Contemporary Ethical Considerations for Pediatric Metabolic and Bariatric Surgery.

J Pediatr Surg

October 2024

Section of Pediatric Surgery, Department of Surgery, The University of Chicago, Chicago, IL, USA; The MacLean Center for Clinical Medical Ethics, The University of Chicago, Chicago, IL, USA. Electronic address:

Background: The prevalence of pediatric obesity continues to increase dramatically. Though metabolic and bariatric surgery (MBS) is efficacious and is supported by high-quality data in this population, it remains underutilized. This paper aims to discuss current ethical concerns, considerations, and controversies of pediatric MBS.

View Article and Find Full Text PDF
Article Synopsis
  • Medication holidays in inflammatory bowel disease (IBD) aim to balance effective disease management with cost and quality of life, especially given the chronic nature and treatment side effects of IBD.
  • The review discusses the rationale behind medication holidays, how to implement them, potential risks, and strategies to monitor patients and manage relapses.
  • Experts emphasize the importance of careful patient selection, ongoing management, and the need for better predictive models and monitoring technologies to safely integrate medication holidays into standard treatment practices.
View Article and Find Full Text PDF

Association of nonstandardized model for end-stage liver disease score exceptions with waitlist mortality in adult liver transplant candidates.

Am J Transplant

September 2024

Department of Medicine, University of Chicago, Chicago, IL; Department of Public Health Sciences, University of Chicago, Chicago, IL; Maclean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL. Electronic address:

In the US liver allocation system, nonstandardized model for end-stage liver disease (MELD) exceptions (NSEs) increase the waitlist priority of candidates whose MELD scores are felt to underestimate their true medical urgency. We determined whether NSEs accurately depict pretransplant mortality risk by performing mixed-effects Cox proportional hazards models and estimating concordance indices. We also studied the change in frequency of NSEs after the National Liver Review Board's implementation in May 2019.

View Article and Find Full Text PDF

When Fulfilling a Professional Obligation Causes Moral Distress: A New Evaluative Approach.

J Intensive Care Med

September 2024

MacLean Center for Clinical Medical Ethics and Department of Surgery, University of Chicago, Chicago, IL, USA.

Purpose: The term 'moral distress' was coined by Andrew Jameton to name the anguish that clinicians feel when they cannot pursue what they judge to be right because of institutional constraints. We argue that moral distress in critical care should also be addressed as a function of the constraints of ethics and propose an evaluative approach to the experience considering its implications for professional identity.

Method: We build on a selective review of the literature and analyze a paradigmatic example of moral distress, namely, clinicians who feel compelled to perform procedures on patients that seem futile.

View Article and Find Full Text PDF

Background: Critical illness, or acute organ failure requiring life support, threatens over five million American lives annually. Electronic health record (EHR) data are a source of granular information that could generate crucial insights into the nature and optimal treatment of critical illness. However, data management, security, and standardization are barriers to large-scale critical illness EHR studies.

View Article and Find Full Text PDF
Article Synopsis
  • The increasing use of interventional techniques in chronic pain patients on anticoagulant and antiplatelet therapy poses challenges in balancing the bleeding risk from these medications and the thrombosis risk from discontinuation.
  • Guidelines have been developed through a literature review and expert consensus to help assess and manage the risks of bleeding and thrombosis during interventional procedures for these patients.
  • These guidelines provide a framework for healthcare professionals to make informed decisions regarding the continuation or temporary suspension of anticoagulant and antiplatelet therapy in the context of interventional pain management.
View Article and Find Full Text PDF

Complexities of autonomy in military medical ethics: A brief report.

J Trauma Acute Care Surg

August 2024

From the Department of Defense Medical Ethics Center (M.K.A., J.G., C.B., A.K., F.L.), Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Surgery and MacLean Center for Clinical Medical Ethics (M.K.A.), University of Chicago, Chicago, Illinois; Department of Surgery (M.M.), University of Southern California, Los Angeles, California; Department of Surgery (J.B.H.), University of Alabama at Birmingham, Birmingham, Alabama; Department of Surgery (J.M.G.), San Antonio Military Health System, San Antonio, Texas; Uniformed Services University of The Health Sciences (J.Y.), Bethesda, Maryland.

The first Fallen Surgeons Military Educational Symposium was convened in conjunction with the the American Association for the Surgery of Trauma (AAST) 23 meeting, under the guidance of the AAST Military Liaison Committee. The daylong session included a 1.5-hour segment on military medical ethics in combat and its unique challenges.

View Article and Find Full Text PDF

Ethics and downstream effects of travel for transplant in the United States.

Clin Liver Dis (Hoboken)

June 2024

Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, Illinois, USA.

View Article and Find Full Text PDF

The impending hepatology workforce shortage: Ethical considerations for closing the gap.

Clin Liver Dis (Hoboken)

June 2024

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

1_qcjfgvmgKaltura.

View Article and Find Full Text PDF

Implications of the Law on Reproductive and Sexual Health.

Obstet Gynecol Clin North Am

June 2024

Department of Obstetrics and Gynecology, The University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, IL 60637, USA; The MacLean Center for Clinical Medical Ethics, The University of Chicago, 5841 South Maryland Avenue, MC 6098, Chicago, IL 60637, USA. Electronic address:

The United States has a longstanding history of using laws to define the scope of government involvement in controlling personal matters related to sex and sexuality. Although the government serves a valuable role in protecting and promoting public health, sexual and reproductive health is unduly impacted by social stigma in ways that other fields of medicine are not. Consequently, this care is often singled out by legislation that limits rather than protects this care.

View Article and Find Full Text PDF

Background: The US Kidney Allocation System allocates en bloc deceased donor kidney grafts from donors <18 kg in sequence A along with single kidney transplants (SKTs) from kidney donor profile index (KDPI) top 20% donors. Although en bloc grafts outperform SKT grafts holding donor weight constant, it is unclear if en bloc grafts from the smallest pediatric donors perform the same as top 20% KDPI SKTs.

Methods: Using the Scientific Registry of Transplant Recipients, we compared the donor characteristics and graft survival of en bloc grafts from the smallest donors (<8 kg) and from larger donors (≥8 kg) with SKTs by KDPI sequence for transplants performed in 2021.

View Article and Find Full Text PDF
Article Synopsis
  • The principle of respect for patient autonomy has become more prominent in medicine, leading to challenges for surgeons when a patient wants a surgery that may not be beneficial due to their health condition.
  • Surgeons commonly experience moral distress when faced with requests for nonbeneficial surgeries, leading to the need for guidance on when to decline such requests ethically.
  • The text outlines four concepts to support surgeons: understanding "futility," differentiating between patients' rights, emphasizing the fiduciary duty of surgeons, and applying virtue ethics to ensure care is in the best interest of patients.
View Article and Find Full Text PDF

Association of Race and Ethnicity With High Longevity Deceased Donor Kidney Transplantation Under the US Kidney Allocation System.

Am J Kidney Dis

October 2024

Department of Medicine, University of Chicago, Chicago, Illinois; MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois; Department of Public Health Sciences, University of Chicago, Chicago, Illinois. Electronic address:

Rationale & Objective: The US Kidney Allocation System (KAS) prioritizes candidates with a≤20% estimated posttransplant survival (EPTS) to receive high-longevity kidneys defined by a≤20% Kidney Donor Profile Index (KDPI). Use of EPTS in the KAS deprioritizes candidates with older age, diabetes, and longer dialysis durations. We assessed whether this use also disadvantages race and ethnicity minority candidates, who are younger but more likely to have diabetes and longer durations of kidney failure requiring dialysis.

View Article and Find Full Text PDF

Post-transplant survival after normothermic regional perfusion versus direct procurement and perfusion in donation after circulatory determination of death in heart transplantation.

J Heart Lung Transplant

June 2024

Department of Medicine, University of Chicago, Chicago, Illinois; Department of Public Health Sciences, University of Chicago, Chicago, Illinois; MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois. Electronic address:

Background: Since 2019, the annual transplantation rate of hearts donated following circulatory death (DCD) has increased significantly in the United States. The 2 major heart procurement techniques following circulatory death are direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). Post-transplant survival for heart recipients has not been compared between these 2 techniques.

View Article and Find Full Text PDF
Article Synopsis
  • The US heart allocation system prioritizes patients most at risk of death without a transplant, but its current method is flawed and can be manipulated.
  • Researchers aimed to create a new risk score, the US Candidate Risk Score (US-CRS), using clinical data to enhance decision-making for heart transplant candidates.
  • A study involving nearly 17,000 candidates validated the US-CRS, which proved more effective than existing models in predicting mortality rates before transplant.
View Article and Find Full Text PDF

Decision-Making in Surgery.

Ann Thorac Surg

June 2024

Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

Surgeons face unique challenges in perioperative decision-making and communication with patients and families. In cardiothoracic surgery, the stakes are high, life and death decisions must be made quickly, and surgeons often lack a longstanding relationship with patients and families prior to intervention. This review considers specific challenges in the preoperative period followed by those faced postoperatively.

View Article and Find Full Text PDF

Background: Sociodemographic disparities in physician decisions to withhold and withdraw life-sustaining treatment exist. Little is known about the content of hospital policies that guide physicians involved in these decisions.

Research Question: What is the prevalence of US hospitals with policies that address withholding and withdrawing life-sustaining treatment; how do these policies approach ethically controversial scenarios; and how do these policies address sociodemographic disparities in decisions to withhold and withdraw life-sustaining treatment?

Study Design And Methods: This national cross-sectional survey assessed the content of hospital policies addressing decisions to withhold or withdraw life-sustaining treatment.

View Article and Find Full Text PDF

Apnea Test: The Family in the Room.

Neurocrit Care

August 2024

Division of Neurocritical Care, Departments of Neurology and Neurosurgery, MacLean Center for Clinical Medical Ethics, The University of Chicago Medicine, University of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

View Article and Find Full Text PDF