15 results match your criteria: "Mackenzie Presbyterian Institute[Affiliation]"

4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.

J Proteome Res

January 2025

PPGEMN, School of Engineering, Mackenzie Presbyterian University & MackGraphe - Mackenzie Institute for Research in Graphene and Nanotechnologies, Mackenzie Presbyterian Institute, São Paulo, São Paulo 01302-907, Brazil.

Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past two years. In this study, we investigated for the first time the host salivary response of COVID-19 patients infected with Omicron variants (BA.1, BA.

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Article Synopsis
  • Omics techniques were used during the COVID-19 pandemic to enhance our understanding of the virus, find biomarkers for diagnosis and prognosis, and identify new drug targets.
  • The study analyzed saliva samples from both COVID-19 positive and negative volunteers during the Omicron variant's rise, using non-target metabolomics to identify potential biomarkers for screening.
  • The developed model successfully distinguished COVID-19 positive individuals with high rates of sensitivity, specificity, and accuracy, linking the identified salivary signatures to immune responses and suggesting a need for further research on endocrine imbalances in mild cases.
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Covalently cross-linked 2D heterostructures may represent a ground-breaking approach to creating materials with multifunctionalities. To date, however, this field still remains relatively unexplored. In the present work, CoO/GO covalently linked heterostructures (CoO/GO-CL) were produced using 2D-CoO functionalized with (3-aminopropyl)triethoxysilane (APTES) to react with the carboxyl groups of graphene oxide (GO).

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Electrochemical water splitting is a promising approach in the development of renewable energy technologies, providing an alternative to fossil fuels. It has attracted considerable attention in recent years. The benchmark materials used in water splitting are precious metals that are expensive and scarce.

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Biotite, an iron-rich mineral belonging to the trioctahedral mica group, is a naturally abundant layered material (LM) exhibiting attractive electronic properties for application in nanodevices. Biotite stands out as a non-degradable LM under ambient conditions, featuring high-quality basal cleavage-a significant advantage for van der Waals heterostructure (vdWH) applications. In this work, we present the micro-mechanical exfoliation of biotite down to monolayers (1Ls), yielding ultrathin flakes with large areas and atomically flat surfaces.

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  • The study highlights the influence of substrate properties on the photothermal reduction process of graphene oxide (GO) when converted to reduced graphene oxide (rGO) using a 405 nm laser.
  • The effectiveness of rGO conversion is tested on three types of flexible membranes—nylon, cellulose acetate, and nitrocellulose—resulting in significantly low sheet resistance values.
  • The research also explores the application of these flexible rGO materials as temperature sensors, with nylon membranes exhibiting the best sensitivity due to their superior surface quality.
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This study investigates the scope of application of a recently designed inversion methodology that is capable of obtaining structural information about disordered systems through the analysis of their conductivity response signals. Here we demonstrate that inversion tools of this type are capable of sensing the presence of disorderly distributed defects and impurities even in the case where the scattering properties of the device are only weakly affected. This is done by inverting the DC conductivity response of monolayered MoSfilms containing a minute amount of AuClcoordinated complexes.

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Full-thickness cutaneous trauma, due to the lack of dermis, leads to difficulty in epithelialization by keratinocytes, developing a fibrotic scar, with less elasticity than the original skin, which may have disorders in predisposed individuals, resulting in hypertrophic scar and keloids. Biomedical materials have excellent characteristics, such as good biocompatibility and low immunogenicity, which can temporarily replace traditional materials used as primary dressings. In this work, we developed two dermal matrices based on Nile tilapia collagen, with (M_GAG) and without (M) glycosaminoglycans, using a sugarcane polymer membrane as a matrix support.

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Recent progress in synthesizing and integrating surface-supported metal-organic frameworks (SURMOFs) has highlighted their potential in developing hybrid electronic devices with exceptional mechanical flexibility, film processability, and cost-effectiveness. However, the low electrical conductivity of SURMOFs has limited their use in devices. To address this, researchers have utilized the porosity of SURMOFs to enhance electrical conductivity by incorporating conductive materials.

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  • The rising demand for clean energy and the negative environmental effects of fossil fuels have led to increased use of renewable energy sources, including biomass and thermal processes.
  • The study provides a detailed chemical analysis of sludges from domestic and industrial wastewater treatment and the bio-oils produced through fast pyrolysis, using several advanced characterization techniques.
  • The results indicate that while bio-oils contain a significant amount of nitrogenous compounds, making them unsuitable as renewable fuels, they have potential for recovery processes to produce valuable products like fertilizers and surfactants.
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This study aimed to investigate how an ultralow content of a molybdenum disulfide (MoS) two-dimensional particle affects the photodegradation mechanism of polystyrene (PS). Here, an accelerated weathering study was presented on neat polystyrene and its nanocomposites produced with 0.001, 0.

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Niobium disulfide is a layered transition metal dichalcogenide that is being exploited as a two-dimensional material. Although it is a superconductor at low temperatures and demonstrates great potential to be applied as a catalyst or co-catalyst in hydrogen evolution reactions, only a few reports have demonstrated the synthesis of a few-layer NbS. However, before applications can be pursued, it is essential to understand the main characteristics of the obtained material and its stability under an atmospheric environment.

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The development of flexible and conformable devices, whose performance can be maintained while being continuously deformed, provides a significant step toward the realization of next-generation wearable and e-textile applications. Organic field-effect transistors (OFETs) are particularly interesting for flexible and lightweight products, because of their low-temperature solution processability, and the mechanical flexibility of organic materials that endows OFETs the natural compatibility with plastic and biodegradable substrates. Here, an in-depth review of two competing flexible OFET technologies, planar and vertical OFETs (POFETs and VOFETs, respectively) is provided.

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The use of graphene in surface plasmon resonance sensors, covering a metallic (plasmonic) film, has a number of demonstrated advantages, such as protecting the film against corrosion/oxidation and facilitating the introduction of functional groups for selective sensing. Recently, a number of works have claimed that few-layer graphene can also increase the sensitivity of the sensor. However, graphene was treated as an isotropic thin film, with an out-of-plane refractive index that is identical to the in-plane index.

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Article Synopsis
  • Two-dimensional materials (2DM) have unique properties that can be adjusted through techniques like doping and surface functionalization, increasing their potential applications in various fields.
  • The study explores how MoS monolayers interact with different 3d transition metals, revealing coordination complexes that depend on the nature of the transition metal's bonding character.
  • Results show trends in charge transfer and doping mechanisms, where metals like Ni lead to n-type doping and Cu leads to p-type doping, suggesting that modifying MoS surfaces can effectively control material properties without creating defects.
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