35 results match your criteria: "Mackenzie Evangelical University Hospital[Affiliation]"
Fam Cancer
November 2024
Ophir Loyola Hospital, Belém, Pará, 66063-240, Brazil.
Hum Immunol
November 2024
Ophir Loyola Hospital, Belém, Pará, 66063-240, Brazil.
Background: Breast cancer (BC) is a significant global health issue, accounting for 1 in 8 cancer diagnoses worldwide. HLA class I molecules are typically expressed on the cell surface, but cancer cells can develop mechanisms to evade recognition by CTLs, including the downregulation of HLA class I expression. In this context, we aimed to conduct a systematic review and meta-analysis to clarify the role of HLA class I expression in clinical outcomes for patients with BC.
View Article and Find Full Text PDFWorld Neurosurg
December 2024
Neurosurgery Department, Mackenzie Evangelical University Hospital, Curitiba, Brazil.
Objectives: Carry out an update and systematic review on the use of three-dimensional printing (3DP) in spinal surgery.
Methods: A systematic literature review was performed using the PubMed database in March 2024. "Spine surgery" and "3DP" were the search terms.
Clin Breast Cancer
December 2024
Mackenzie Evangelical University Hospital, Curitiba, 80730-150, Brazil.
Background: Breast cancer (BC) is a global problem, however, despite ALND is considered the standard treatment for early stage BC with node-positive, there is no sufficient data to determine which of these patients should undergo it. Thus, the aim of this systematic review was to clarify if there is any difference between NALND and ALND in terms of safety and prognosis of the patients.
Methods: A shearch was carried in PubMed, Embase and Cochrane databases for studies that compared NALND and ALND.
Neurosurgery
December 2024
Department of Neurosurgery, Federal University of Paraná, Curitiba , Paraná , Brazil.
Education and training are essential components of global neurosurgery because they provide a sustainable solution to address the workforce deficits in the neurosurgical burden of disease. Neurosurgery training programs and opportunities exist in most areas of the world, but some countries still lack formal mechanisms to train future generations. In this special article, we review the neurosurgical workforce deficit, characterize factors influencing the absence or inadequacy of neurosurgical training, and identify strategies that could facilitate global efforts in building a stronger workforce.
View Article and Find Full Text PDFWorld Neurosurg
October 2024
Radiology Department, Agua Verde Diagnostic Clinic, Curitiba, Brazil.
Objective: The use of biomodels in the laboratory for studying and training cervical laminoplasty has not yet been reported. We propose the use of a cervical spine biomodel for surgical laminoplasty training.
Methods: This is an experimental study.
Clin Genitourin Cancer
October 2024
Department of Clinical Oncology, Mackenzie Evangelical University Hospital, Curitiba, Parana 80730-150, Brazil.
Introduction: Platinum-based chemotherapy (CTX) has historically been the primary treatment for advanced urothelial cancer (aUC), with limited alternative options. The therapeutic landscape experienced a paradigm shift following the results of the EV-302 and Checkmate-901 trials, which led to the approval of Enfortumab vedotin plus pembrolizumab (EV-P) as the preferred first-line treatment, and nivolumab plus CTX for those unable to receive the preferred regimen. Currently, further investigations are underway to explore PD-1 and PD-L1 inhibitors in the initial treatment of aUC.
View Article and Find Full Text PDFJ Surg Oncol
September 2024
Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Traditionally, lobectomy was standard for stage IA non-small-cell lung cancer (NSCLC). Recent RCTs suggest sublobar resection's comparable outcomes. Our meta-analysis, incorporating 30 studies (including four RCTs), assessed sublobar resection's efficacy.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2024
Ophir Loyola Hospital, Belém, Pará, 66063-240, Brazil.
Introduction: Incorporation of AKT inhibitors into adjuvant therapy for advanced or metastatic breast cancer has improved clinical outcomes. However, the safety of AKT inhibitors should be better evaluated, given the possibility of prolonging survival and impacting patient quality of life. Our aim was to assess how the addition of AKT inhibitors to adjuvant therapy affects treatment-related adverse events.
View Article and Find Full Text PDFJ Pers Med
April 2024
Oncology Research Center, Federal University of Pará, Belem 66073-005, Brazil.
Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are approved for advanced breast cancer combined with endocrine therapy (ET). The efficacy of CDK4/6 inhibitors plus ET in hormone estrogen-positive, human epidermal growth factor 2-negative (HR+/HER2-) early-stage breast cancer (esBC) is still to be confirmed.
Methods: We performed a systematic review and a meta-analysis to investigate the efficacy of CDK4/6i plus ET in esBC.
Front Pharmacol
May 2024
Department of Medicine, Federal University of Pará, Belém, Pará, Brazil.
Background: The CDK 4/6 inhibitors, including palbociclib and ribociclib, are the standard first-line treatment for hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. Proton pump inhibitors are one of the most globally prescribed types of medications as part of the treatment for gastroesophageal reflux and heartburn complaints. Medication interactions have been demonstrated, leading to a decrease in the effectiveness of chemotherapy drugs such as capecitabine and pazopanib.
View Article and Find Full Text PDFAdv Tech Stand Neurosurg
May 2024
Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, PR, Brazil.
Paragangliomas are the most common tumors at jugular foramen and pose a great surgical challenge. Careful clinical history and physical examination must be performed to adequately evaluate neurological deficits and its chronologic evolution, also to delineate an overview of the patient performance status. Complete imaging evaluation including MRI and CT scans should be performed, and angiography is a must to depict tumor blood supply and sigmoid sinus/internal jugular vein patency.
View Article and Find Full Text PDFAdv Rheumatol
April 2024
Reumathology Service, Mackenzie Evangelical University Hospital, Curitiba, Paraná, Brazil.
Background: Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy.
Methods: A cross-sectional study including consecutive patients with PsO and PsA was carried out.
World Neurosurg
July 2024
Department of Neurosurgery, Aviation General Hospital, Beijing, China. Electronic address:
Moyamoya disease is a progressive nonatherosclerotic stenosis of the terminal segments of the arteries of the Circle of Willis. Hemorrhagic presentation is a life-threatening condition, associated with an increased risk of rebleeding and ischemic events. We present the case of a 65-year-old woman with a right intracerebral hemorrhage who underwent emergency hematoma evacuation without bone flap replacement (Video 1).
View Article and Find Full Text PDFRev Assoc Med Bras (1992)
January 2024
Mackenzie Evangelical School of Medicine of Paraná - Curitiba (PR), Brazil.
Objective: Patients with rheumatic diseases have an increased risk of infections, especially tuberculosis. In this study, we aimed to recognize the positivity rate of tuberculosis skin test in patients with rheumatoid arthritis and spondyloarthritis and the characteristics of the patients with positive results.
Methods: Retrospective study of tuberculosis skin test results in patients followed from 2004 to 2021 in a single rheumatology unit.
Int J Mol Sci
December 2023
Oncology Research Center, Federal University of Pará, Belem 66075-110, Brazil.
Papillary subtypes of renal-cell carcinoma (pRCC) represent 10-15% of the cases and commonly have MET alterations. This systematic review and single-arm meta-analysis evaluated MET inhibitor therapy (METi) efficacy and safety in adults with confirmed advanced pRCC. The search strategy included PubMed, Web-of-science, Cochrane, and Scopus.
View Article and Find Full Text PDFBMC Cancer
November 2023
Oncology Research Center, Federal University of Pará, University Hospital João de Barros de Barreto, Rua dos Mundurucus, nº4487, Belém, 66073-000, PA, Brazil.
Background: Paclitaxel and carboplatin is the standard chemotherapy for the treatment of advanced or recurrent endometrial cancer. However, the benefit of adding programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors to chemotherapy is still unclear.
Method: We searched PubMed, Scopus, Cochrane, and Web of Science databases for randomized controlled trials that investigated PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer.
Cureus
August 2023
Department of Critical Care, Hospital da Cidade, Salvador, BRA.
Osteogenesis imperfecta (OI) constitutes a complex connective tissue disorder extending beyond its hallmark bone fragility. This case report explores the intricate diagnostic journey involving an elderly patient with acute chest pain, blue sclerae, and multiple fractures. Despite a thorough cardiac evaluation yielding normal results, the complex medical history and phenotypic markers directed attention toward musculoskeletal factors, underlining the importance of comprehensive diagnostic approaches in hereditary conditions like OI.
View Article and Find Full Text PDFWorld Neurosurg
November 2023
Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, PR, Brazil; Department of Neurosurgery, Rehabilitation Hospital Center Ana Carolina Moura Xavier, Curitiba, PR, Brazil; Department of Neurosurgery, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address:
Objective: The development of microsurgical skills is crucial for neurosurgical education. The human placenta is a promising model for practicing vascular anastomosis due to its similarities with brain vessels. We propose a 2-stage model for training in extracranial-to-intracranial anastomosis using the placenta.
View Article and Find Full Text PDFSurg Neurol Int
August 2023
Department of Neurosurgery, San Fernando Hospital, San Fernando, Argentina.
Background: Focal cortical dysplasia (FCD) is one of the main causes of intractable epilepsy, which is amendable by surgery. During the surgical management of FCD, the understanding of its epileptogenic foci, interconnections, and spreading pathways is crucial for attaining a good postoperative seizure free outcome.
Methods: We retrospectively evaluated 54 FCD patients operated in Federal Center of Neurosurgery, Tyumen, Russia.
An Acad Bras Cienc
August 2023
Pontifical Catholic University of Paraná (PUC-PR), Experimental Laboratory of the Institute of Biology and Health Sciences, R. Imaculada Conceição, 1155, Prado Velho, 80215-901 Curitiba, PR, Brazil.
The treatment of tracheal pathologies remains challenging.Nanotechnology allows adding substances to decellularized human amniotic membrane (DHAM), such as 15-Deoxy-∆12,14ProstaglandinJ2 nanoparticles (15D-PGJ2-NC).This study performed a tracheotomy in rabbits randomized into three groups.
View Article and Find Full Text PDFOper Neurosurg (Hagerstown)
December 2023
Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paraná, Brazil.
Indications Corridor And Limits Of Exposure: This approach is intended for tumors centered in the jugular foramen with extensions between intracranial and extracranial spaces, possible spread to the middle ear, and variable bony destruction. 1,2.
Anatomic Essentials Need For Preoperative Planning And Assessment: Jugular foramen paragangliomas are complex lesions that usually invade and fill related venous structures.
J Crit Care
October 2023
Department of Pulmonary and Critical Care, New York University School of Medicine, New York, NY, USA.
Purpose: The optimal amount of anticoagulation for critically ill COVID-19 patients is controversial. Therefore, we aimed to evaluate the efficacy and safety of escalated doses of anticoagulation in critically ill patients with severe COVID-19.
Materials And Methods: We conducted a systematic search of three major databases, including PubMed, Cochrane Library, and Embase, from inception to May 2022.
Oper Neurosurg (Hagerstown)
August 2023
Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paraná, Brazil.
J Psoriasis Psoriatic Arthritis
April 2023
Clinical Dermatology, Department of Dermatology, Mackenzie Evangelical University Hospital, Curitiba, Brazil.
Background: During the past decades, several unconventional strategies for controlling chronic inflammatory diseases, including psoriasis, have been developed. The use of probiotics has been gaining importance as an adjuvant therapy in the treatment of these pathologies.
Objectives: Evaluate the impact of the use of the probiotic strain in patients diagnosed with common and palmoplantar psoriasis.