Human-Computer Interaction in Healthcare: A Bibliometric Analysis with CiteSpace.

Background/objectives: Studies on the application and exploration of human-computer interaction (HCI) technologies within the healthcare sector have rapidly expanded, showcasing the immense potential of HCI to enhance medical services, elevate patient experiences, and advance health management. Despite this proliferating interest, there is a notable shortage of comprehensive bibliometric analyses dedicated to the application of HCI in healthcare, which limits a thorough comprehension of the growth trends and future trajectories in this area.

Methods: To bridge this gap, we employed bibliometric methods using the CiteSpace tool to systematically review and analyze the current state and trends of HCI research in healthcare.

Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.

SET and MYND Domain-Containing 2 (Smyd-2), a specific protein lysine methyltransferase (PKMT), influences both histones and non-histones. Its role in cerebral ischemia/reperfusion (CIR), particularly in ferroptosis-a regulated form of cell death driven by lipid peroxidation-remains poorly understood. This study identifies the expression of Smyd-2 in the brain and investigates its relationship with neuronal programmed cell death (PCD).

Advances in statin adverse reactions and the potential mechanisms: A systematic review.

Background: Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Statins are the cornerstone of preventing and treating cardiovascular disease and can reduce LDL cholesterol by more than 60%. Although statins have high tolerability and safety, as the number of users increases, their adverse reactions in the liver, kidneys, skeletal muscles, and their potential to induce diabetes have also received widespread attention.

Lithium Use During Pregnancy in 14 Countries.

Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.

Objective: To examine lithium use in the perinatal period.

A Novel Shear-Detachment Approach for Modeling Dynamics of Membrane Cleaning.

We report a novel shear-detachment (SD) approach to simulate the dynamics of flux recovery in the membrane cleaning process. In this model, the rate of foulant detachment away from the membrane is governed by both the shear intensity and the probability of successful foulant detachment, with the latter modeled by Boltzmann distribution. Our SD predictions exhibit good agreement with experimental results, accurately capturing the dynamics of flux recovery.

Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.

Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile.

The dynamic distribution patterns and lung targeting efficiency in rats of 9 bioactive components in Siraitia grosvenorii.

Ethnopharmacological Relevance: Siraitia grosvenorii (S. grosvenorii) is a traditional herbal medicine employed for the prevention of lung diseases. Mogrosides and flavonoids are postulated to be the principal active components.

Bromine signature coded derivatization LC-MS for specific profiling of carboxyl or carbonyl-containing metabolites in Mycoplasma pneumoniae infection.

Carboxyl or carbonyl-containing metabolites (CoCCMs) are widely distributed in biological samples. Global profiling of CoCCMs is essential for ascertaining specific functions of metabolites and their potential physiological roles in biogenic activities. However, simultaneous determination of these compounds is hampered by poor ionization efficiency, vast polarity differences, wide discrepancy of concentration ranges.

Multimodal data fusion AI model uncovers tumor microenvironment immunotyping heterogeneity and enhanced risk stratification of breast cancer.

Breast cancer is the leading cancer among women, with a significant number experiencing recurrence and metastasis, thereby reducing survival rates. This study focuses on the role of long noncoding RNAs (lncRNAs) in breast cancer immunotherapy response. We conducted an analysis involving 1027 patients from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, and The Cancer Genome Atlas, utilizing RNA sequencing and pathology whole-slide images.

Role of Cancer History in Cardiovascular Mortality Among Different Age-group Patients With Differentiated Thyroid Cancer.

Background: Cardiovascular disease (CVD) is the leading cause of noncancer-related mortality among differentiated thyroid cancer (DTC) survivors, which accounts for a large portion of subsequent primary malignancies in childhood cancer survivors. This study aims to assess the risk of cardiovascular mortality among DTC as a second primary malignancy (DTC-2) patients compared with DTC as a first primary malignancy (DTC-1) and the general population.

Methods: Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study including 159 395 DTC-1 and 20 010 DTC-2 patients diagnosed older than 30 between 1975 and 2020 and the corresponding US population (71 214 642 person-years; 41 420 893 cardiovascular deaths).

Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study.

This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described.

Developing positive design with innovative thinking framework: A design pedagogical approach to enhance subjective well-being.

Design thinking is the foundation of professional design education, and the shift from zero to professional design skill involves the completion of the transition from single-mindedness to independent and innovative thinking. In this exploratory study on design teaching, we build a novel teaching model by drawing on the connection between students' self-transcendent knowledge and formal knowledge in design thinking. Based on the Design for Happiness framework (DfH), this study uses Positive Emotional Granularity cards (PEG) to stimulate students to identify and categorize various positive emotions.

Efficiency Boost in Through Space Charge Transfer Emitters: Insights from Spiro Lateral Rocking Confinement.

Intramolecular through-space charge-transfer (TSCT) excited states have emerged as promising candidates for thermally activated delayed fluorescence (TADF) emitters. This study addresses the challenges in tuning excited state dynamics through conformational engineering, which significantly impacts exciton utilization. An effective strategy is presented to enhance the performance of TSCT-TADF molecules by restricting the lateral rocking of the spiro unit via immobilizing groups, which indirectly adjusts the conformations of the donor and acceptor subunits.

Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.

Introduction: Chronic kidney disease (CKD) has long represented a substantial global health challenge. Regrettably, current therapeutic interventions exhibit limited efficacy in halting the progression of CKD. Ferroptosis may play a crucial role in CKD, as indicated by substantial evidence.

Narrowband emission and enhanced stability in top-emitting OLEDs with dual resonant cavities.

Capping layers (CPLs) are commonly employed in top-emitting organic light-emitting diodes (TEOLEDs) due to their ability to optimize color purity, enhance external light out-coupling efficiency, and improve device stability. However, the mismatch in refractive index between CPLs and thin film encapsulation (TFE) often induces light trapping. This study introduces a novel approach by combining a low refractive index material, lithium fluoride (LiF), with the traditional TFE material, silicon nitride (SiN), to form a combined CPL (LiF/SiN), resulting in improved light outcoupling and light reflection properties.

Self-improving generative foundation model for synthetic medical image generation and clinical applications.

In many clinical and research settings, the scarcity of high-quality medical imaging datasets has hampered the potential of artificial intelligence (AI) clinical applications. This issue is particularly pronounced in less common conditions, underrepresented populations and emerging imaging modalities, where the availability of diverse and comprehensive datasets is often inadequate. To address this challenge, we introduce a unified medical image-text generative model called MINIM that is capable of synthesizing medical images of various organs across various imaging modalities based on textual instructions.

Integration of osimertinib-targeted EGFR gene-associated differential gene expression in constructing a prognostic model for lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is one of the deadliest cancers. Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-targeted therapy is an important approach for treating LUAD. However, the development of acquired resistance poses a serious clinical challenge.

A review: strategies for reducing the open-circuit voltage loss of wide-bandgap perovskite solar cells.

Perovskite-based tandem solar cells (PTSCs) have made remarkable achievements in recent years, and the highest certified power conversion efficiency (PCE) of 33.9% has been achieved in perovskite/silicon tandem solar cells (PSTSCs), indicating their great commercialization potential. Nevertheless, the performance of PTSCs continues to be hindered by the compromised performance of wide-bandgap perovskite solar cells (WPSCs), particularly the high deficit of WPSCs.

The effectiveness of sanggenon c in alleviating SLC7A11-induced ferroptosis in lung cancer was evaluated using in vivo, in vitro, and computational approaches.

Sanggenon c, a component in Morus alba L, has been proved to possess various biological activities. The aim of this study is to investigate whether sanggenon c can target SLC7A11 and inhibit lung cancer by regulating the ferroptosis mechanism. The levels of antioxidant factor, Fe , and SLC7A11 were measured in the lungs of cancerous mice and human A 549 lung cancer cells.

Particulate Matter 2.5 concentration prediction system based on uncertainty analysis and multi-model integration.

Air pollution has become a major threat to global public health. Therefore, in order to reduce the harm caused by air pollution, effectively protect people's well-being and promote the sustainable development of ecological environment, it is urgent to scientifically establish an accurate and reliable pollutant concentration early warning system. However, existing researches often ignore the influence of data noise on trend prediction, and face many challenges in information extraction and uncertainty estimation.

Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies.

To date, several studies have integrated genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data from bulk tissues to identify novel Alzheimer's disease (AD) genetic variants and susceptibility genes. However, there is highly cell-type-specific nature in different bulk eQTL data. Until now, eQTL data from different brain single cells have been reported.