Anti-depression molecular mechanism elucidation of the phytochemicals in edible flower of Baroni.

The edible flower of Baroni, commonly known as "Huang Huacai" in China, has anti-depressant effects. However, targets and molecular mechanisms of Baroni edible flowers (HEF) in depression treatment are still unclear. The potential anti-depression targets in HEF were identified by the intersecting results from typical drug databases.

Tracing Sentinel Lymph Nodes and Inhibiting Lymphatic Metastasis with TiN Nanobipyramids Through Photothermal Therapy.

Background: The lymphatic system is the major route of cancer metastasis, and sentinel lymph nodes (SLNs) are the first station for the spread of cancer cells. Accurate identification of SLNs by tracers during surgery is crucial for SLN biopsy and lymphadenectomy. However, conventional monomodal tracers such as blue dyes and carbon nanoparticles often induce a misjudgment of SLNs and thus are still unsatisfying for clinical applications.

Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model.

Background: Retinal ganglion cell (RGC) death caused by acute ocular hypertension is an important characteristic of acute glaucoma. Receptor-interacting protein kinase 3 (RIPK3) that mediates necroptosis is a potential therapeutic target for RGC death. However, the current understanding of the targeting agents and mechanisms of RIPK3 in the treatment of glaucoma remains limited.

A Respiratory Signal Monitoring Method Based on Dual-Pathway Deep Learning Networks in Image-Guided Robotic-Assisted Intervention System.

Background: Percutaneous puncture procedures, guided by image-guided robotic-assisted intervention (IGRI) systems, are susceptible to disruptions in patients' respiratory rhythm due to factors such as pain and psychological distress.

Methods: We developed an IGRI system with a coded structured light camera and a binocular camera. Our system incorporates dual-pathway deep learning networks, combining convolutional long short-term memory (ConvLSTM) and point long short-term memory (PointLSTM) modules for real-time respiratory signal monitoring.

Diagnosis of Isolated Central Vertigo: Report for a Series Cases.

Vertigo, including central and peripheral causes, is one of the common symptoms in patients who are admitted to neurological outpatient and emergency rooms. Despite the advancements in imaging techniques in recent years, central vertigo is difficult to identify and is often misdiagnosed in clinical practice. In this study, 4 patients were admitted to the hospital with complaints of dizziness or vertigo.

Synergistic Enhancement of Plasma-Driven Ammonia Synthesis Using a AuCu/Cu Composite Catalyst.

Green ammonia synthesis using fluctuating renewable energy supply in decentralized process is a goal that has been long sought after. Ammonia synthesis with non-thermal plasma under mild conditions is a promising technology, but it faces the critical challenge of low energy efficiency. Herein, we develop an easily-scalable AuCu/Cu catalyst, which consists of a decimeter-scale metallic Cu antenna and nano-scale AuCu catalytic sites on metallic Cu surface, significantly enhancing the energy efficiency and ammonia yield in a radio-frequency (RF) plasma system.

Combined pyrotinib and fulvestrant for hormone receptor-positive and HER2-positive metastatic breast cancer: A multicenter, single-arm, phase II trial.

This multicenter, single-arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR-positive/HER2-positive metastatic breast cancer who had experienced trastuzumab treatment failure. A total of 46 patients were enrolled, receiving pyrotinib orally once daily and fulvestrant intramuscularly on days 1 and 15 of cycle 1, followed by monthly doses on day 1. The primary endpoint was progression-free survival (PFS), while secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety.

Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.

T-cell acute lymphoblastic leukaemia (T-ALL) is a common childhood malignant tumour, which has poor prognosis and high recurrence rate. Ginsenoside Rh2 (GRh2), a bioactive ingredient of has significant anti-tumour effect. In this study, we found that gene expressions of Jurkat cells were significantly changed in the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signalling pathways after 35 µm GRh2 treatment, involving in JUN, PIEN, AKT3 and MAPK8IP2.

Co-creation with AI: A painting therapy program aimed at ameliorating attention deficits in children with ADHD.

Art therapy has been proven to be efficacious in alleviating symptoms of children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD), with the advent of artificial intelligence providing new technological means to engage and increase the participation levels of ADHD children. Nonetheless, research on the application of AI in art therapy remains scant. This study, predicated on a method involving ADHD children co-creating art with AI, has devised a therapeutic activity aimed at ameliorating their attention deficits.

Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy.

Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis, necroptosis, cuproptosis, pyroptosis, and NETosis. Mutations in cancer cells may prevent the RCD pathway; therefore, targeting RCD in tumors has become a promising therapeutic approach.

The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review.

Atherosclerosis (AS) is a major etiological factor underpinning a spectrum of cardiovascular diseases, leading to cerebral infarction, coronary artery disease, and peripheral vascular disease. The chronic progression of AS, spanning from initial plaque formation to the occurrence of acute cardiovascular events, underscores the complexity of AS and the challenges it presents in terms of treatment. Currently, the clinical management of AS relies predominantly on statins and proprotein convertase subtilisin/kexin type 9 inhibitors, which primarily aim to reduce low-density lipoprotein levels and have demonstrated some therapeutic efficacy.

Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling.

The influenza A virus (IAV) damages intestinal mucosal tissues beyond the respiratory tract. Probiotics play a crucial role in maintaining the balance and stability of the intestinal microecosystem. Extracellular vesicles (EVs) derived from probiotics have emerged as potential mediators of host immune response and anti-inflammatory effect.

LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells.

Background: Cellular senescence is a key driver of decreased bone formation and osteoporosis. Leptin (LEP) has been implicated in cellular senescence and osteogenic differentiation. The aim of this study was to investigate the mechanisms by which LEP mediates cellular senescence and osteogenic differentiation.

Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy.

Targeted charged alpha- and beta-particle therapies are currently being used in clinical radiation treatments as newly developed methods for either killing or controlling tumor cell growth. The alpha particles can be generated either through a nuclear decay reaction or in situ by a nuclear fission reaction such as the boron neutron capture reaction. Different strategies have been employed to improve the selectivity and delivery of radiation dose to tumor cells based on the source of the clinically used alpha particles.

Myeloid response evaluated by noninvasive CT imaging predicts post-surgical survival and immune checkpoint therapy benefits in patients with hepatocellular carcinoma.

Background: The potential of preoperative CT in the assessment of myeloid immune response and its application in predicting prognosis and immune-checkpoint therapy outcomes in hepatocellular carcinoma (HCC) has not been explored.

Methods: A total of 165 patients with pathological slides and multi-phase CT images were included to develop a radiomics signature for predicting the imaging-based myeloid response score (iMRS). Overall survival (OS) and recurrence-free survival (RFS) were assessed according to the iMRS risk group and validated in a surgical resection cohort ( = 98).

Analysis on the contents of Macao elderly care service policy.

The global trend of an increasingly ageing society poses significant healthcare and socio-economic challenges for policymakers and caregivers. As Macao, China, entered an ageing society, policymakers were deeply concerned about this issue, then they launched a ten-year action plan in 2016 to improve healthcare services and increase geriatric education, which made great progress. This research aims to investigate the impact of these policy tools on elderly care services by using the content analysis method to analyze the "Macao Special Administrative Region Elderly Security Mechanism and Ten-Year Action Plan for Elderly Services from 2016 to 2025".

Extreme R-CNN: Few-Shot Object Detection via Sample Synthesis and Knowledge Distillation.

Traditional object detectors require extensive instance-level annotations for training. Conversely, few-shot object detectors, which are generally fine-tuned using limited data from unknown classes, tend to show biases toward base categories and are susceptible to variations within these unknown samples. To mitigate these challenges, we introduce a Two-Stage Fine-Tuning Approach (TFA) named Extreme R-CNN, designed to operate effectively with extremely limited original samples through the integration of sample synthesis and knowledge distillation.

Human-Computer Interaction in Healthcare: A Bibliometric Analysis with CiteSpace.

Background/objectives: Studies on the application and exploration of human-computer interaction (HCI) technologies within the healthcare sector have rapidly expanded, showcasing the immense potential of HCI to enhance medical services, elevate patient experiences, and advance health management. Despite this proliferating interest, there is a notable shortage of comprehensive bibliometric analyses dedicated to the application of HCI in healthcare, which limits a thorough comprehension of the growth trends and future trajectories in this area.

Methods: To bridge this gap, we employed bibliometric methods using the CiteSpace tool to systematically review and analyze the current state and trends of HCI research in healthcare.

Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.

SET and MYND Domain-Containing 2 (Smyd-2), a specific protein lysine methyltransferase (PKMT), influences both histones and non-histones. Its role in cerebral ischemia/reperfusion (CIR), particularly in ferroptosis-a regulated form of cell death driven by lipid peroxidation-remains poorly understood. This study identifies the expression of Smyd-2 in the brain and investigates its relationship with neuronal programmed cell death (PCD).