Arrhythmia classification based on multi-feature multi-path parallel deep convolutional neural networks and improved focal loss.

Early diagnosis of abnormal electrocardiogram (ECG) signals can provide useful information for the prevention and detection of arrhythmia diseases. Due to the similarities in Normal beat (N) and Supraventricular Premature Beat (S) categories and imbalance of ECG categories, arrhythmia classification cannot achieve satisfactory classification results under the inter-patient assessment paradigm. In this paper, a multi-path parallel deep convolutional neural network was proposed for arrhythmia classification.

Relationship between affiliate stigma and family quality of life among parents of children with autism spectrum disorders: The mediating role of parenting self-efficacy.

Background: The parents of children with autism spectrum disorder (ASD) are under great pressure and experience discrimination in their daily lives, which affects their family quality of life (FQOL).

Objective: METHODS: A total of 237 parents of children with ASD were recruited in a university-affiliated hospital in Guangzhou, China, from October 2020 to April 2021 by convenience sampling. The Affiliate Stigma Scale, Parenting Sense of Competence Scale and Beach Center Family Quality of Life Scale were employed for data collection.

The Multimorbidity and Lifestyle Correlates in Chinese Population Residing in Macau: Findings from a Community-Based Needs Assessment Study.

Multimorbidity has become one of the most pressing public health concerns worldwide. The objectives of this study were to understand the prevalence of multimorbidity and its relationship with lifestyle factors among Chinese adults in Macau, and to investigate the combined contribution of common lifestyle factors in predicting multimorbidity. Data were collected through face-to-face interviews using a self-reported questionnaire on common chronic diseases, lifestyle factors and sociodemographics.

The Impact of Sprint Interval Exercise in Acute Severe Hypoxia on Executive Function.

Kong, Zhaowei, Qian Yu, Shengyan Sun, On Kei Lei, Yu Tian, Qingde Shi, Jinlei Nie, and Martin Burtscher. The impact of sprint interval exercise in acute severe hypoxia on executive function. .

Employee Perceptions of Responsible Gambling in Macao: Concepts, Indicators, and Intervention Barriers.

Despite the importance of venue employees in identifying problem gamblers and making interventions, little is known concerning what role venue employees play in responsible gambling practices in Macao. This study examined what venues employees' perceptions of responsible gambling are, how they detect problem gamblers, and what barriers are impeding them from taking action. Semi-structured interviews with 49 venue staff in Macao yielded a wealth of in-depth data that were then thematically analyzed.

Affective and Enjoyment Responses to Sprint Interval Training in Healthy Individuals: A Systematic Review and Meta-Analysis.

Unlabelled: Sprint interval training (SIT) is characterized by intensity of "all-out" effort and superior time-efficiency compared to traditional moderate-intensity continuous training (MICT) and has been proposed as one viable solution to address the commonly reported barrier of lack of time for physical activity. While substantial physiological benefits of participation in SIT have been well-documented, the psychological responses to SIT are less clear. No systematic review has been conducted thus far to respond to the assumption that its supramaximal intensity will induce adverse feelings.

Image Classification of Alzheimer's Disease Based on External-Attention Mechanism and Fully Convolutional Network.

Automatic and accurate classification of Alzheimer's disease is a challenging and promising task. Fully Convolutional Network (FCN) can classify images at the pixel level. Adding an attention mechanism to the Fully Convolutional Network can effectively improve the classification performance of the model.

FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity.

Genome editing technologies hold tremendous potential in biomedical research and drug development. Therefore, it is imperative to discover gene editing tools with superior cutting efficiency, good fidelity, and fewer genomic restrictions. Here, we report a CRISPR/Cas9 from Faecalibaculum rodentium, which is characterized by a simple PAM (5'-NNTA-3') and a guide RNA length of 21-22 bp.

Deciphering the Effect of Lysine Acetylation on the Misfolding and Aggregation of Human Tau Fragment IPAKTPPAPK Using Molecular Dynamic Simulation and the Markov State Model.

The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer's Disease. It has been reported that acetylation, especially K174 located in the proline-rich region, can largely promote Tau aggregation. So far, the mechanism of the abnormal acetylation of Tau that affects its misfolding and aggregation is still unclear.

Promoting enteral tube feeding safety and performance in preterm infants: A systematic review.

Background: Enteral tube feeding is commonly used in preterm infants to provide enteral nutrition. Nurses play a crucial role in promoting feeding safety and performance.

Objectives: The aims of this systematic review were to identify nursing practices regarding feeding safety and performance promotion in preterm infants with enteral tube feeding and summarize evidence on the effectiveness of these practices.

Hypoxic repeated sprint interval training improves cardiorespiratory fitness in sedentary young women.

Objective: The purpose of this study was to investigate the effects of repeated sprint interval training (RSIT) under different hypoxic conditions in comparison with normoxic RSIT on cardiorespiratory fitness (CRF) and metabolic health in sedentary young women.

Methods: Sixty-two sedentary young women (age: 21.9 ± 2.

Cardiac autonomic disturbance following sprint-interval exercise in untrained young males: Does exercise volume matter?

Objectives: This study examined the influences of the volume of all-out sprint-interval exercise (SIE) on acute post-exercise heart rate variability (HRV) recovery.

Methods: HRV recovery following a session of (i) 2 × 30-s SIE (SIE), (ii) 4 × 30-s SIE (SIE), and (iii) non-exercising control (CON) were compared in 15 untrained young males. Time domain [standard deviation of normal-to-normal intervals, root mean square of successive R-R differences] and frequency domain [low frequency (0.

Exercise Training Increases Serum Cardiac Troponin T Independent of Left Ventricular Mass.

The purpose of this study was to determine whether exercise training mediated cardiac troponin T (cTnT) and whether this was associated with increases in left ventricular mass (LVM). Fifty-four sedentary obese women were randomised to high-intensity interval training (HIIT, repeated 4-min cycling at 90% V̇O interspersed with 3-min rest), work-equivalent continuous aerobic training (CAT, continuous cycling at 60% V̇O) or a control group (CON). Resting serum cTnT was assessed using a high-sensitivity assay before and after 12 weeks of training.

The Influence of Social Capital on Youths' Anti-Epidemic Action in the Field of Epidemic-Preventative Social Distancing in China.

Social distancing restrictions for COVID-19 epidemic prevention have substantially changed the field of youths' social activities. Many studies have focused on the impact of epidemic-preventative social distancing on individual physical and mental health. However, in the field of social distancing for epidemic prevention, what are the changes in youth anti-epidemic action and states caused by their interpersonal resources and interactions? Responding to this question by studying the impact of the elements of social capital in youths' anti-epidemic actions and anti-epidemic states could help identify an effective mechanism for balancing social distancing for effective epidemic prevention and sustainable social-participation development among youth.

Impact of cocrystal solution-state stability on cocrystal dissociation and polymorphic drug recrystallization during dissolution.

The present study aimed to investigate how cocrystal solution-state stability may affect the polymorphic drug formation and transition during dissolution. In this work, curcumin-resorcinol (CUR-RES), curcumin-hydroquinone (CUR-HYQ) and curcumin-phloroglucinol (CUR-PHL) cocrystals were employed for dissolution studies in three buffer systems to study the effects of solvent and cocrystal thermodynamic stability. The undissolved solids were collected at designed time points and characterized by powder X-ray diffraction, differential scanning calorimetry and scanning electron microscopy.

Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.

The emerging new lineages of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have marked a new phase of coronavirus disease 2019 (COVID-19). Understanding the recognition mechanisms of potent neutralizing monoclonal antibodies (NAbs) against the spike protein is pivotal for developing new vaccines and antibody drugs. Here, we isolated several monoclonal antibodies (MAbs) against the SARS-CoV-2 spike protein receptor-binding domain (S-RBD) from the B cell receptor repertoires of a SARS-CoV-2 convalescent.

Impact of high-intensity interval and moderate-intensity continuous exercise on heart rate variability and cardiac troponin.

Background: It remains uncertain whether exercise modality (high-intensity interval [HIE]; moderate-intensity continuous [MCE]) mediates exercise-induced changes in markers of pro-arrhythmogenic state and/or cardiac damage. This study examines heart rate variability (HRV) and cardiac troponin T (cTnT) kinetic responses to HIE and MCE.

Methods: Fourteen sedentary, overweight/obese females completed two trials including HIE (2-min running at 90% V̇O2max followed by 2-min running at 50% V̇O2max, repeated for 60 min) and MCE (70% V̇O2max steady-state running for 60 min) in a randomized, counterbalanced fashion.

Affective and Enjoyment Responses to Sprint Interval Exercise at Different Hypoxia Levels.

Benefits of performing sprint interval training (SIT) under hypoxic conditions on improving cardiorespiratory fitness and body composition have been well-documented, yet data is still lacking regarding affective responses to SIT under hypoxia. This study aimed to compare affective responses to SIT exercise under different oxygen conditions. Nineteen active males participated in three sessions of acute SIT exercise (20 repetitions of 6 s of all-out cycling bouts interspersed with 15 s of passive recovery) under conditions of normobaric normoxia (SL: PIO 150 mmHg, FIO 0.

Mapping the knowledge domain of the evolution of emergy theory: a bibliometric approach.

Bibliometric and visualization tools are effective for uncovering information contained in vast amounts of literature data. We retrieved publications from the Web of Science (2008-2020) and used the Statistical Analysis Toolkit for Informetrics (SATI) and CiteSpace to conduct a bibliometric analysis of emergy studies, review the focus of the studies, summarize current research, and identify academic trends. The SATI-based charts provided an overall description of yearly published articles, literature sources, high-frequency keywords, authors, institutions, and highly cited papers.