431 results match your criteria: "Macalester College; chatterjead@macalester.edu.[Affiliation]"

Dissociating murine skin into a single cell suspension is essential for downstream cellular analysis such as the characterization of infiltrating immune cells in rodent models of skin inflammation. Here, we describe a protocol for the digestion of mouse skin in a nutrient-rich solution with collagenase D, followed by separation of hematopoietic cells using a discontinuous density gradient. Cells thus obtained can be used for in vitro studies, in vivo transfer, and other downstream cellular and molecular analyses including flow cytometry.

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Moral judgment as information processing: an integrative review.

Front Psychol

November 2015

Department of Psychology, Macalester College, Saint Paul MN, USA.

How do humans make moral judgments about others' behavior? This article reviews dominant models of moral judgment, organizing them within an overarching framework of information processing. This framework poses two distinct questions: (1) What input information guides moral judgments? and (2) What psychological processes generate these judgments? Information Models address the first question, identifying critical information elements (including causality, intentionality, and mental states) that shape moral judgments. A subclass of Biased Information Models holds that perceptions of these information elements are themselves driven by prior moral judgments.

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Article Synopsis
  • Transfer of electrophilic alkoxyl groups from tetrahydropyranyl monoperoxyacetals to organometallic reagents allows for efficient ether production, overcoming previous challenges with peroxide stability.
  • The method yields a variety of ethers, including alkyl, alkenyl, and aryl types, and operates without generating alkoxy radical intermediates, unlike traditional peroxide reactions.
  • Theoretical analysis indicates that the reaction mechanism likely involves a Lewis acid facilitating the insertion of organometallics into the O-O bond, rather than a straightforward nucleophilic substitution (SN2) process.
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Gold monosulfide, AuS, has been detected and characterized in the gas phase using optical spectroscopy. The symmetries of the ground and low-lying electronic excited states have been determined by application of a synergy of hot and cold laser excitation techniques. The electronic spectra are assigned to progressions in four band systems associated with excitations from the X(2)Πi ((2σ)(2)(2π)(3)) ground state to the A(2)Σ(+) state arising from the (2σ)(1)(2π)(4) configuration and to the a(4)Σ(-), B(2)Σ(-), and C(2)Δi states arising from the (2σ)(2)(2π)(2)(3σ*)(1) configuration.

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Prey individuals with complex life-histories often cannot predict the type of risk environment to which they will be exposed at each of their life stages. Because the level of investment in defences should match local risk conditions, we predict that these individuals should have the ability to modulate the expression of an integrated defensive phenotype, but this switch in expression should occur at key life-history transitions. We manipulated background level of risk in juvenile damselfish for four days following settlement (a key life-history transition) or 10 days post-settlement, and measured a suite of physiological and behavioural variables over 2 weeks.

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  • The reaction between sulfur dioxide (SO2) and Criegee intermediates (CIs) is significant for producing sulfuric acid aerosols, which affect climate change through radiative forcing.
  • This study employs advanced quantum chemical methods to analyze the formation and breakdown of a specific adduct known as the HOZ, highlighting the dominance of exo conformers while endo conformers are stabilized through hyperconjugation.
  • Results show a reaction rate coefficient aligning with experiments and indicate that over 95% of carbonyl and SO3 production results from interactions between CIs and SO2, with high-energy transition states contributing to SO3 formation.
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The current study examined children's identification and reasoning about their subjective social status (SSS), their beliefs about social class groups (i.e., the poor, middle class, and rich), and the associations between the two.

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Mechanism of the Intramolecular Hexadehydro-Diels-Alder Reaction.

J Org Chem

December 2015

Department of Chemistry, Macalester College, Saint Paul, Minnesota 55105-1899, United States.

Theoretical analysis of the mechanism of the intramolecular hexadehydro-Diels-Alder (HDDA) reaction, validated against prior and newly measured kinetic data for a number of different tethered yne-diynes, indicates that the reaction proceeds in a highly asynchronous fashion. The rate-determining step is bond formation at the alkyne termini nearest the tether, which involves a transition-state structure exhibiting substantial diradical character. Whether the reaction then continues to close the remaining bond in a concerted fashion or in a stepwise fashion (i.

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Background: In 2012, the World Health Organization estimated that there were 120,000 new cases and 9500 deaths due to tuberculosis (TB) in Kenya. Almost a quarter of the cases were not detected, and the treatment of 4% of notified cases ended in default.

Objective: To identify the determinants of anti-tuberculosis treatment default.

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Best Practices: The Neuroscience Program at Central Michigan University.

J Undergrad Neurosci Educ

August 2015

Department of Psychology and Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859; ; Field Neurosciences Institute, Saginaw MI 48604.

The original design of our program at Central Michigan University (CMU) and its evolving curriculum were directly influenced by Faculty for Undergraduate (FUN) workshops at Davidson College, Oberlin College, Trinity College, and Macalester College. The course content, laboratory exercises, and pedagogy used were informed by excellent articles in the Journal of Undergraduate Neuroscience Education (JUNE) and presentations at these FUN workshops and meetings over the years. Like the program at Baldwin-Wallace College, which was a previous winner of the Undergraduate Neuroscience Program of the Year Award, as selected by the Committee on Neuroscience Departments and Programs (CNDP) of the Society for Neuroscience (SfN, our program stresses the importance of inquiry-based, hands-on research experience for our undergraduates and utilizes a peer-mentoring system.

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3D-printed slit nozzles for Fourier transform microwave spectroscopy.

Rev Sci Instrum

June 2015

Department of Chemistry, University of Minnesota, 207 Pleasant St., SE, Minneapolis, Minnesota 55455, USA.

3D printing is a new technology whose applications are only beginning to be explored. In this report, we describe the application of 3D printing to the design and construction of supersonic nozzles. Nozzles can be created for $0.

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Topological data analysis of biological aggregation models.

PLoS One

February 2016

Department of Mathematics, Statistics, and Computer Science, Macalester College, Saint Paul, Minnesota, United States of America.

We apply tools from topological data analysis to two mathematical models inspired by biological aggregations such as bird flocks, fish schools, and insect swarms. Our data consists of numerical simulation output from the models of Vicsek and D'Orsogna. These models are dynamical systems describing the movement of agents who interact via alignment, attraction, and/or repulsion.

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The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.

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Background: Parkinson's disease (PD) is associated with stooped postural alignment, increased postural sway, and reduced mobility. The Alexander Technique (AT) is a mindfulness-based approach to improving posture and mobility by reducing muscular interference while maintaining upward intentions. Evidence suggests that AT can reduce disability associated with PD, but a mechanism for this effect has not yet been established.

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Making the Blue Zones: Neoliberalism and nudges in public health promotion.

Soc Sci Med

May 2015

Geography Department, Macalester College, 1600 Grand Ave, St Paul, MN 55105, USA. Electronic address:

This paper evaluates the ideological and political origins of a place-based and commercial health promotion effort, the Blue Zones Project (BZP), launched in Iowa in 2011. Through critical discourse analysis, I argue that the BZP does reflect a neoliberalization of public health, but as an "actually existing neoliberalism" it emerges from a specific policy context, including dramatic health sector policy changes due to the national Affordable Care Act, also known as Obamacare; a media discourse of health crisis for an aging Midwestern population; and an effort to refashion Iowa cities as sites of healthy and active living, to retain and attract a creative class of young entrepreneurs. The BZP employs many well-known mechanisms of neoliberal governance: the public-private partnership; competition among communities for "public" funds; promotion of an apolitical discourse on individual responsibility and ownership of health; decentralizing governance to the "community" level; and marketing, branding, and corporate sponsorship of public projects.

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A series of d(6) metal complexes of tris(diphenylphosphinomethyl)phenylborate ([PhB(CH2PPh2)3](-), PhBP3), including [Et4N][M(CO)3(PhBP3)] (M = Cr, Mo, W), inaugural group VI metal tris(phosphino)borate complexes, and zwitterionic Mn(CO)3(PhBP3) have been synthesized and fully characterized. An analysis of IR ν(CO) data for [Et4N][M(CO)3(PhBP3)] indicates that PhBP3 is significantly less strongly donating than Tp towards zerovalent M(CO)3 fragments; PhBP3 does not function as a strongly donating scorpionate in this system as its does towards cationic metal fragments suggesting that PhBP3 may not function as an effective surrogate of hydrotris(1-pyrazolyl)borate towards zerovalent metals. While the metal centers of [Et4N][M(CO)3(PhBP3)] are very likely still more electron-rich than those of M(CO)3(triphos), the anions of [Et4N][M(CO)3(PhBP3)] do not provide robust oxidative addition products analogous to those of M(CO)3(triphos).

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The reviews are in: resources for undergraduate neuroscience education.

J Undergrad Neurosci Educ

January 2015

Department of Psychology and Neuroscience Program, Macalester College, Saint Paul, MN 55105.

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231Pa/230Th evidence for a weakened but persistent Atlantic meridional overturning circulation during Heinrich Stadial 1.

Nat Commun

December 2014

Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, 266 Woods Hole Road, Woods Hole, Massachusetts 02543, USA.

The strength of Atlantic meridional overturning circulation is believed to affect the climate over glacial-interglacial and millennial timescales. The marine sedimentary (231)Pa/(230)Th ratio is a promising paleocirculation proxy, but local particle effects may bias individual reconstructions. Here we present new Atlantic sedimentary (231)Pa/(230)Th data from the Holocene, the last glacial maximum and Heinrich Stadial 1, a period of abrupt cooling ca.

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Gravity-driven instability of a thin liquid film underneath a soft solid.

Phys Rev E Stat Nonlin Soft Matter Phys

November 2014

Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA.

The gravity-driven instability of a thin liquid film located underneath a soft solid material is considered. The equations and boundary conditions governing the solid deformation are systematically converted from a Lagrangian representation to an Eulerian representation, which is the natural framework for describing the liquid motion. This systematic conversion reveals that the continuity-of-velocity boundary condition at the liquid-solid interface is more complicated than has previously been assumed, even in the small-strain limit.

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In their 2012 report, the President's Council of Advisors on Science and Technology advocated "replacing standard science laboratory courses with discovery-based research courses"-a challenging proposition that presents practical and pedagogical difficulties. In this paper, we describe our collective experiences working with the Genomics Education Partnership, a nationwide faculty consortium that aims to provide undergraduates with a research experience in genomics through a scheduled course (a classroom-based undergraduate research experience, or CURE). We examine the common barriers encountered in implementing a CURE, program elements of most value to faculty, ways in which a shared core support system can help, and the incentives for and rewards of establishing a CURE on our diverse campuses.

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Previously known only from isolated teeth and lower jaw fragments recovered from the Cretaceous and Palaeogene of the Southern Hemisphere, the Gondwanatheria constitute the most poorly known of all major mammaliaform radiations. Here we report the discovery of the first skull material of a gondwanatherian, a complete and well-preserved cranium from Upper Cretaceous strata in Madagascar that we assign to a new genus and species. Phylogenetic analysis strongly supports its placement within Gondwanatheria, which are recognized as monophyletic and closely related to multituberculates, an evolutionarily successful clade of Mesozoic mammals known almost exclusively from the Northern Hemisphere.

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