4,201 results match your criteria: "Maastricht University Medical Center (MUMC); Maastricht 6229HX[Affiliation]"

Reaching Syrian migrants through Dutch municipal registries for hepatitis B and C point-of-care testing.

PLoS One

January 2025

Department of Sexual Health, Infectious Diseases and Environmental Health, Living Lab Public Health, South Limburg Public Health Service, Heerlen, The Netherlands.

Undetected chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections can lead to cirrhosis and liver cancer. Syrian migrants are the largest non-European migrant group in the Netherlands with HBV and HCV prevalence rates above 2%. This study aimed to reach Syrian migrants for HBV and HCV testing using point-of-care tests (POCT).

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Purpose: In resective epilepsy surgery for drug-resistant focal epilepsy (DRE), good seizure outcome is strongly associated with visualization of an epileptogenic lesion on MRI. Standard clinical MRI (≤ 3 Tesla (T)) may fail to detect subtle lesions. 7T MRI enhances detection and delineation, the potential benefits of increasing field strength to 9.

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The neuronal correlate of tremor genesis and cognitive function in essential tremor (ET) and its modulation by deep brain stimulation (DBS) are poorly understood. To explore the underlying metabolic topography of motor and cognitive symptoms, sixteen ET patients (age 63.6 ± 49.

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Prolonged incubation time unwarranted for acute periprosthetic joint infections.

J Clin Microbiol

January 2025

Department of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Centre, Maastricht, the Netherlands.

Unlabelled: Current laboratory protocols for periprosthetic joint infections (PJIs) involve a standard 10- to 14-day incubation period. However, recent evidence indicates considerable variability in the time to diagnosis (TTD) between acute and chronic PJIs. TTD is also influenced by the employed culture media and sample types.

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Background: Randomized controlled trials (RCTs) have failed to demonstrate the beneficial effects of the pharmacological treatment of patent ductus arteriosus (PDA) in preterm infants. We conducted a Bayesian model averaged (BMA) meta-analysis of RCTs comparing the pharmacological treatment of PDA with placebo or expectant treatment.

Methods: We searched for RCTs including infants with gestational age (GA) ≤ 32 weeks and with a rate of open-label treatment of less than 25% in the control arm.

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Background And Purpose: Successful and complete reperfusion should be the aim of every endovascular thrombectomy (EVT) procedure. However, the effect of time delays on successful reperfusion in late window stroke patients presenting 6-to-24 h from onset has not been investigated.

Materials And Methods: We pooled individual patient-level data from seven trials and registries for anterior circulation stroke patients treated with EVT between 6 and 24 h from onset.

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This paper reviews the literature on assessing electrical dyssynchrony for patient selection in cardiac resynchronization therapy (CRT). The guideline-recommended electrocardiographic (ECG) criteria for CRT are QRS duration and morphology, established through inclusion criteria in large CRT trials. However, both QRS duration and LBBB morphology have their shortcomings.

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Evaluating the Implementation of Home-Based Sexual Health Care Among Men Who Have Sex with Men: Limburg4zero.

AIDS Behav

January 2025

Department of Sexual Health, Infectious Diseases and Environmental Health, Living Lab Public Health Mosa, Public Health Service South Limburg, Heerlen, The Netherlands.

Home-based sexual health care (including self-sampling testing) could reduce barriers to clinic-based testing. This study systematically evaluated the implementation of home-based sexual health care ('Limburg4Zero') among men who have sex with men (MSM) in a mixed urban-rural region of the Netherlands. We systematically assessed implementation outcomes (contextual domains, population reached, effectiveness, adoption by health care providers (HCP), implementation fidelity, and maintenance) using the practical, robust implementation and sustainability model.

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ACT in Daily Life (ACT-DL) is a blended-care Ecological Momentary Intervention that extends ACT into the daily life of individuals, improving psychotic distress, negative symptoms, and global functioning. However, it remains unclear whether ACT-DL works equally for everyone. We investigated whether moderators (i.

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Background: Due to malnutrition and tumor cachexia, body composition (BC) is frequently altered and known to adversely affect short- and long-term results in patients with cholangiocarcinoma (CCA). Here, we explored immune cell populations in the tumor and liver of CCA patients with respect to BC.

Methods: A cohort of 96 patients who underwent surgery for CCA was investigated by multiplexed immunofluorescence (MIF) techniques with computer-based analysis on whole-tissue slide scans to quantify and characterize immune cells in normal liver and tumor regions.

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Learning to hear again with alternating cochlear frequency allocations.

Sci Rep

January 2025

Department of ENT/Audiology & School for Mental Health and NeuroScience (MHENS), Maastricht University Medical Centre, Maastricht, The Netherlands.

Traditionally, the place-pitch 'tonotopically' organized auditory neural pathway was considered to be hard-wired. Cochlear implants restore hearing by arbitrarily mapping frequency-amplitude information. This study shows that recipients, after a long period of sound deprivation, preserve a level of auditory plasticity, enabling them to swiftly and concurrently learn speech understanding with two alternating, distinct frequency maps.

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Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma.

Mol Diagn Ther

December 2024

Comprehensive Cancer Center, University of Maastricht, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Introduction: Anorectal melanoma is a rare neoplasm with an aggressive behavior and poor prognosis. Recently, recurrent gene mutations related to anorectal melanoma have been identified in a small series of cases, and this holds promise for targeted therapies, analogous to cutaneous melanoma. The purpose of this study was to analyze testing rates and prevalence of mutations in anorectal melanoma in the Dutch population.

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Inducing cylindrical and spherical defocus after implantation with new generation intraocular lenses improves intermediate and near visual acuity.

Sci Rep

December 2024

Imaging, Biomechanics and Mathematical Modelling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.

An induced cylinder and spherical power after implantation with an extended depth of focus (EDOF) and enhanced monofocal intraocular lens (IOL) could improve distance, intermediate (60 cm) and near (40 cm) visual acuity (VA). In this prospective study, forty eyes with Eyhance EDOF IOL (Johnson and Johnson, USA) and 40 eyes with Vivity EDOF IOL (Alcon Laboratories Inc. USA) were included.

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Functional screening identifies miRNAs with a novel function inhibiting vascular smooth muscle cell proliferation.

Mol Ther

December 2024

Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK; CARIM School for Cardiovascular Sciences, Department of Pathology, Maastricht University Medical Center (MUMC), 6229HX Maastricht, the Netherlands. Electronic address:

Article Synopsis
  • The study identifies seven microRNAs (miRNAs) that inhibit the proliferation of vascular smooth muscle cells (vSMCs), important in preventing vascular remodeling issues.
  • Through high-throughput screening of 2,042 human miRNA mimics, the researchers pinpointed miR-323a-3p, miR-449b-5p, miR-491-3p, miR-892b, miR-1827, miR-4774-3p, and miR-5681b as effective in reducing vSMC proliferation.
  • The findings suggest these miRNAs could be developed into therapeutic agents, particularly for conditions like vein graft failure, showing minimal toxicity and altering key cell-cycle gene networks involved in
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Background: Pharmacological treatment is a cornerstone of chronic obstructive pulmonary disease (COPD) management, with general practitioners providing the most care. However, the lack of data on prescribing trends in initial pharmacotherapy in primary care hinders the understanding of how scientific and technical developments impact patient care and may also perpetuate suboptimal practices. Hence, this study aims to analyze trends in the initial pharmacological treatment of newly diagnosed COPD patients in Dutch primary care from 2010 to 2021.

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Challenges to Students' Learning and Wellbeing During Placement Abroad: A Qualitative Study Using Rich Pictures.

Perspect Med Educ

December 2024

School of Health Professions Education (SHE), Faculty of Health, Medicine and Life sciences, Maastricht University, Maastricht, The Netherlands.

Introduction: Undergraduate healthcare students on placement abroad can experience challenges that affect their wellbeing, personal and professional development. These challenges may result in students taking a more peripheral role in workplace activities, which negatively impacts learning. We studied .

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Bullet characterization using Photon-Counting detector CT: A phantom study with intact bullets.

Eur J Radiol

December 2024

Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, PO Box 5800, 6202 AZ Maastricht, the Netherlands; Mental Health and Sciences (MHeNs) Research Institute, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.

Objectives: Photon-counting detector CT (PCD-CT) is expected to substantially improve and expand CT-imaging applicability due to its intrinsic spectral capabilities, increased spatial resolution, reduced electronic noise, and improved image contrast. The current study aim is to evaluate PCD-CT efficacy in characterizing bullets based on their dimensions, shape, and material composition.

Materials And Methods: This is an observational phantom study examining 11 unfired, intact bullets of various common calibers, placed in ballistic gelatin.

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Accuracy and Reliability of Grip Strength Measurements: A Comparative Device Analysis.

J Funct Morphol Kinesiol

December 2024

University Center for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, CH-8008 Zurich, Switzerland.

Grip strength is widely used as a surrogate parameter for functional status. The current gold standard, the JAMAR Hydraulic Dynamometer (JAMAR Hydraulic), presents challenges for individuals with painful finger joints or low grip strength. Therefore, the objective of this observational study was to assess comparability across the JAMAR Smart, the Martin Vigorimeter and the gold standard.

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NLRC4-associated autoinflammatory disease: Insights from mouse models and somatic variants.

J Allergy Clin Immunol

December 2024

Department of Microbiology, Immunology, and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium; Department of General Internal Medicine, Division of Allergy and Clinical Immunology, University Hospitals Leuven, Leuven, Belgium.

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Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and developing therapeutic strategies has proven challenging. This is due to the complexity of atherosclerosis with a spatial interplay of multiple cell types within the vascular wall.

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Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.

Health Qual Life Outcomes

December 2024

Department of Research and Development, Hornerheide 1, 6085 NM, Ciro, Horn, The Netherlands.

Rationale: Knowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited.

Objectives: To assess whether and to what extent asthma exacerbations affect changes in PROMS over time and asthma-specific PROMs can predict exacerbations in adult patients with severe asthma in usual care.

Methods: Data of 421 patients with severe asthma (62% female; mean age 51.

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An international and multidisciplinary EORTC survey on resectability of stage III non-small cell lung cancer.

Lung Cancer

December 2024

Department of Pulmonary Medicine, GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX Maastricht, the Netherlands. Electronic address:

Introduction: The EORTC-Lung Cancer Group initiated a Delphi consensus process to establish a consensual definition of resectable stage III non-small cell lung cancer (NSCLC) for the use in clinical trials, including a systematic review, survey, and review of clinical cases. Here, the survey results are presented, aimed to identify areas of controversy.

Methods: A survey was distributed among the members of six international organizations related to lung cancer.

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Aims: To answer the question of whether the bladder itself can to any extent control or modulate the initiation of voiding.

Methods: This subject was discussed at the International Consultation on Incontinence-Research Society (ICI-RS) 2024 conference in Bristol, UK in a proposal session.

Results: Cells in the bladder wall sense the local environment via a diverse array of ion channels and receptors which together provide input to motor-sensory and signal transduction mechanisms.

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