Treatment of vaginal vault prolapse in The Netherlands: a clinical practice survey.

Introduction And Hypothesis: A great variety of conservative and surgical procedures to correct vaginal vault prolapse have been reported. The aim of this study was to describe practice pattern variation-the difference in care that cannot be explained by the underlying medical condition-among Dutch gynecologists regarding treatment of vaginal vault prolapse.

Methods: A clinical practice survey was conducted from March to April 2017.

Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men.

Background: South Asians were reported to have a higher liver fat content as compared to BMI-matched Caucasians. This study compared the increase in liver fat content in response to overfeeding with a high fat diet in South Asian and Caucasian men when matched for body fat percentage.

Methods: Ten South Asian men (BMI 18-29 kg/m(2)) and 10 Caucasian men (BMI 22-33 kg/m(2)), aged 20-40 y, matched for body fat percentage, were included.

Ageing with an intellectual disability: the impact of personal resources on well-being.

Background: The population of ageing people with mild and moderate intellectual disabilities (ID) is growing rapidly. This study examines how personal resources (physical health, mental health and social networks) impact the well-being of ageing people with ID.

Methods: Longitudinal survey data on 667 people with a mild or moderate ID were acquired via interviews in 2006 and 2010.

CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?

Background: In some of our patients with intellectual disabilities (ID) and sleep problems, the initial good response to melatonin disappeared within a few weeks after starting treatment. In these patients melatonin levels at noon were extremely high (>50 pg/ml). We hypothesise that the disappearing effectiveness is associated with slow metabolisation of melatonin because of a single nucleotide polymorphism (SNP) of CYP1A2.

Infected chronic wounds show different local and systemic arginine conversion compared with acute wounds.

Background: Several experimental studies have shown the importance of arginine in wound healing. However, little is known about its role in human wound healing. In this study, we investigated arginine metabolism in impaired wound healing.

The role of nitric oxide in vascular headache.

Shortly after the invention of nitroglycerin (NTG), it was noticed that this substance is capable of inducing a violent headache. Only recently, it became known that this was due to the release of nitric oxide (NO) by NTG. As the molecular mechanism of migraine pain remains to be determined, NTG, being pro-drug for NO, has been used to study the aetiology and pathophysiology of migraine.

Lung and gastric uptake in bone scintigraphy of sarcoidosis.

We report on 99mTc-MDP uptake in lungs and stomach in a patient with hypercalcaemia and renal failure due to elevated 1,25(OH)2vitD3 because of sarcoidosis. Presently, this typical scan pattern has only been described in patients with malignancies, parathyroid adenoma and drug-induced vitamin D intoxication. We offer possible explanations for the findings in our patient.

Preparation, characterization and radiolabeling of a new amphiphilic derivative of DTPA.

A new derivative (1) of diethylenetriamine pentaacetic acid (DTPA) is described. Compound 1 contains a hydrophobic unit (a triphenyl methyl group) and a hydrophilic unit (a DTPA ester), and therefore behaves as an amphiphile in aqueous solution. Compound 1 appears to form a stable inclusion complex with 99mTc.

Evaluation of gracilis muscle transposition for fecal incontinence with magnetic resonance imaging.

Ten consecutive patients with incapacitating fecal incontinence were treated with 'anal dynamic graciloplasty' (transposition of the gracilis muscle around the anal canal and implantation of intramuscular electrodes connected with an implanted pulse generator, 6 weeks later) to achieve continence. We measured the gracilis muscle diameter immediately after transposition and before implantation of the stimulation device. It was found that gracilis diameter decreased from 12 (5 days after transposition) to 8 mm, 6 weeks later (mean decrease: 4 mm (95% confidence interval 3.