Outcomes of Emicizumab in Acquired Hemophilia Patients: A Systematic Review.

Background: Emicizumab, a bispecific factor VIII mimetic antibody, was approved in 2018 for bleeding prophylaxis in congenital hemophilia A with or without inhibitors. Since then, several case reports and case series have described the off-label use of emicizumab in acquired hemophilia A (AHA), and data from two clinical trials were recently published (AGEHA, GTH-AHA-EMI).

Objectives: To describe the reported data on the outcomes of emicizumab, highlighting its benefit/risk profile in treatment.

Challenging case of disseminated tuberculosis in an immunocompetent adult.

Disseminated tuberculosis (TB) is a TB infection involving two or more noncontiguous sites. It is a challenging medical care due to its misleading presentation. Although it is associated with immunodepression, rare cases have been described in immunocompetent patients.

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Introduction: Several non-invasive tests (NIT) have been reported for predicting liver fibrosis to avoid percutaneous liver biopsy (PLB).

Aim: To evaluate the performance of NIT in Tunisian patients with chronic hepatitis B (CHB).

Methods: We calculated the ASAT/platelet ratio index (APRI), GGT-to-platelet ratio (GPR), Fibrosis-4 score (FIB-4), and RDW/platelet ratio (RPR).

Florfenicol induces malformations of embryos and causes altered lipid profile, oxidative damage, neurotoxicity, and histological effects on gonads of adult sea urchin, Paracentrotus lividus.

The frequent occurrence of antibiotics in the aquatic environment has engendered negative impacts on non-target organisms. The effects of the veterinary antibiotic florfenicol (FLO) during the embryo-larval development of the sea urchin, Paracentrotus lividus was assessed using four increasing concentrations (1, 2, 5 and 10 mg/L). Furthermore, FLO toxicity to adults was investigated through the analysis of oxidative damage, histopathological alterations, lipid metabolism and acetylcholinesterase activity following an exposure period of 96 h.

Air embolism complicating endoscopic retrograde cholangiopancreatography.

Venous air embolism is a rare but potentially life threatening complication of endoscopic retrograde cholangiopancreatography. Diagnosis is difficult because of the lack of specific signs or symptoms. A 62-year-old man underwent endoscopic retrograde cholangiopancreatography for choledocholithiasis.

Thyroid storm-induced acute liver dysfunction and portal hypertension in a patient with Graves' disease: a case report.

Thyroid storm is a life-threatening condition associated with multiorgan dysfunction and decompensation. We report the case of a 41-year-old woman having Graves' disease presented with thyroid storm complicated with liver dysfunction and portal hypertension in the absence of congestive heart failure or known liver disease. After successful therapeutic management, all biological, clinical and morphological abnormalities regressed.

Comparative Study for Surgical Treatment of Acute Distal Tibiofibular Syndesmotic Lesions Using the Modified Suture-Button Fixation Versus Static Syndesmotic Screw Fixation.

Introduction: Several techniques to treat acute distal tibiofibular instability are described consisting in static and dynamic fixation procedures. The aim of our work is to compare the outcomes of acute syndesmotic injury fixation between the modified technique of dynamic fixation using the suture-button principle as an efficient and low-cost method and the classic static fixation.

Methods: It is a prospective study including patients presenting with acute syndesmotic injury.

An unusual cause of febrile knee pain in children: Septic arthritis of the proximal tibiofibular joint (a case report).

Introduction And Importance: Septic arthritis (SA), an infection affecting joints, is primarily attributed to bacteria, viruses, or fungi, with the hip, knee, and ankle being common sites of involvement. However, SA of the proximal tibiofibular joint is exceptionally rare. We report a highly uncommon case of lateral knee pain with fever in an 11-year-old boy caused by SA of the proximal tibiofibular joint.

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Introduction: The impact of direct antiviral drugs (DAAs) on extrahepatic manifestations in chronic hepatitis C (CHC) has been poorly studied.

Aim: To assess the prevalence of subclinical atherosclerosis in patients with CHC and the impact of DAAs on atherosclerotic lesions. Methods A 5-year prospective evaluative study, including patients followed for CHC at hepato-gastroenterology department.

Intrathyroid thyroglossal duct cyst: A case report.

Introduction: Thyroglossal duct cysts (TDCs) can be detected in several different locations, although in the literature, intrathyroidal presentations are rare.

Case Presentation: Our patient was a 56-year-old woman who was diagnosed with hypothyroidism and presented with a right-lateral neck mass that was clinically indistinguishable from a thyroid nodule. Cytology revealed normal-looking squamous cells on fine-needle aspiration.

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Helicobacter pylori infection is the most common infectious disease worldwide. It is associated with duodenal and gastric ulcer disease and the risk of gastric neoplasia. The management of helicobacter pylori infection currently represents a real challenge for clinicians, given the ever-increasing rate of resistance of Helicobacter pyolori to various antibiotics.

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Introduction: The ADRESS-HCC score allows predicting the risk of occurrence of Hepatocellular carcinoma in cirrhosis at one year of follow-up.

Aim: Measuring the performance of ADRESS-HCC in predicting the risk of degeneration on post-viral cirrhosis, in a gastroenterology department in Tunisia.

Methods: Retrospective study, including patients followed for compensated viral cirrhosis in the gastroenterology department of the Mohamed Taher Maamouri hospital.

Risk of metabolic syndrome in patients with chronic hepatitis C.

Introduction: Chronic hepatitis C is associated with several metabolic abnormalities including diabetes and insulin resistance. Metabolic syndrome, a major cardiovascular risk factor, may represent an additional risk of morbidity and mortality in patients with viral hepatitis C.

Aim: To assess the risk of metabolic syndrome in patients with chronic hepatitis C and its impact on liver fibrosis.

Surgical management of tibia refracture with a bent intramedullary nail: A case report and review of the literature.

Intramedullary nailing is the gold standard for long bone fractures in the lower limbs. Fractures of the tibia with bending of the intramedullary nail is a very uncommon complication. Removing a bent nail is an unpredictable and challenging procedure for any trauma surgeon.

Risk factors for malunion of distal tibia fractures treated by intramedullary nailing.

Background: The treatment of distal tibia fractures (DTF) has historically been a difficult challenge for orthopedic surgeons because of the particular characteristics of this anatomical region. Intra medullary nailing (IMN) remains the best treatment option. However, achieving and maintaining perfect reduction and stable fixation with IMN can be technically challenging due to the large medullary cavity within a short distal fragment.

Extraspinal osteoarticular tuberculosis: A diagnostic and therapeutic challenge.

Tuberculosis (TB) is a major cause of morbidity and mortality, representing a challenge for health-care providers worldwide. Extraspinal osteoarticular tuberculosis (ESOTB) represents a rare location of TB. We aim to describe ESOTB focusing on clinical, diagnostic, and therapeutic characteristics of this entity.

Influence of Antipsychotic Agents on the Sexuality of Patients Diagnosed with Schizophrenia.

Background: Sexuality is a natural component of human behavior. The general population has been extensively studied since the first half of the 20th century. On the other hand, regarding patients treated for schizophrenia, discussing sexual disorders was initially considered inappropriate because it was believed they should not be sexually active.

Effects of rare earth element samarium doped zinc oxide nanoparticles on Mytilus galloprovincialis (Lamarck, 1819): Filtration rates and histopathology.

Background: Doping was reported to improve the photo catalytic performance, antioxidant, antibacterial and other biological properties of nanoparticles. While, improving the nanoparticle properties, doping could change toxicity profile to living organism. Hence, the aim of this work was to assess the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis.

Qualitative and quantitative endothelium changes after cataract surgery: ultrasound phacoemulsification vs. nanolaser technique.

Purpose: The aim of this study was to evaluate corneal endothelial cell density and morphology, central corneal thickness, and best visual acuity using ultrasound (US) phacoemulsification or nanosecond laser technique.

Setting: Department of ophthalmology, Nabeul, Tunisia.

Design: Prospective cohort study.

Surgical management of neck of femur fractures in patients younger than sixty-five years: a comparative study of three fixation methods.

Purpose: Several surgical implants have been used for the treatment of neck of femur fracture (NOF) in younger patients such as dynamic hip screw (DHS) and cannulated compression screw. However, the superiority of one or another osteosynthesis device remains a matter of debate. The aim of this work is to evaluate and compare three fixation modalities: Cannulated Hip Screws (CHS), DHS and DHS associated to anti-rotating screw for surgical treatment of femoral neck fracture in young adults.

EncephalApp Stroop Test for covert hepatic encephalopathy screening in Tunisian cirrhotic patients.

Covert hepatic encephalopathy (CHE) is underdiagnosed and is difficult to detect. The EncephalApp Stroop test is validated for its screening. The aim of the study was to define Tunisian norms for the test based on healthy controls norms and to estimate the prevalence of CHE in cirrhotic Tunisian patients.