107 results match your criteria: "MS Ramaiah University of Applied Sciences[Affiliation]"

Mondor disease.

BMJ Case Rep

December 2024

General Surgery, MS Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Mondor disease (MD) is a benign inflammatory disorder of the veins over the thoracoabdominal wall. Although the disease has been described for a century, very few descriptions in literature are available. This is due to a lack of awareness among treating physicians about the disease entity as well as the self-limiting course of the disease.

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The research article details the synthesis of chalcone-chromone-based scaffolds via multicomponent reactions. These compounds were characterized using conventional spectroscopic methods, including NMR (H and C), FT-IR, and HR-MS. Among the synthesized scaffolds, AZBNPy stood out, exhibiting exceptional DNA and protein targeting capabilities with superior binding parameters.

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Glioblastoma multiforme (GBM) is the most invasive form of brain tumor, accounting for 5 % of the cases per 100,000 people in various countries. The phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is a well-known tumor suppressor, and its alteration leads to a deleterious effect on GBM progression. The molecular mechanism of tumorigenesis in glial cell types, driven by PTEN status, is yet to be elucidated.

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Implementation Research on Cardiovascular Diseases in India: A Systematic Review.

Indian J Public Health

July 2024

Professor, Department of Public Health, Faculty of Life and Allied Health Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.

Cardiovascular diseases (CVDs) are the leading cause of death globally and the prevention and control of these diseases tend to entail longer and larger social and economic commitments on the part of governments. This systematic review (SR) aims to understand the quantum, diversity, and quality of implementation research (IR) done in the field of CVDs in India with a view to maximizing the utility of the efforts made by the government. The evidence was collated on IR on CVDs in India conducted in the past 20 years (2001-2021) using a SR approach.

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Postprandial hyperglycemia (PPG) exacerbates endothelial dysfunction and impairs vascular function in diabetes as well in healthy people. Though synthetic drugs are available to regulate PPG, the severe gastrointestinal side effects of those medications have prompted the search for alternative treatments. Recently, some phytochemicals captured the attention because of their inhibitory effects on α-amylase to control diabetes.

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Participatory research in mental health care services in low- and middle-income countries: a scoping review protocol.

JBI Evid Synth

July 2024

Evidence Synthesis and Implementation for Indigenous Health: A JBI Affiliated Group, Centre for Public Health Research (CPHR), Manbhum Ananda Ashram Nityananda Trust (MANT), Kolkata, India.

Objective: The objective of this scoping review will be to identify and map the characteristics of participatory research approaches in mental health care services conducted in low- and middle-income countries (LMICs).

Introduction: Developing countries have a treatment gap of 76% to 85% for mental disorders. Participatory research can help understand community perspectives, which, in turn, helps develop sustainable, contextually specific services.

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Background: Human rights provide a universal foundation for pursuing justice in public health in order to achieve the dignity of all individuals. In spite of international attempts to promote human rights in the context of health, a significant portion of India's indigenous population continues to have a limited understanding of these rights.

Objective: This study aims to analyze tribal people's attitudes towards human rights in health care.

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This review presents an in-depth analysis of the immense potential of CRISPR-Cas9 technology in revolutionizing oral cancer research. It underscores the inherent limitations of conventional treatments while emphasizing the pressing need for groundbreaking approaches. The unparalleled capability of CRISPR-Cas9 to precisely target and modify specific genes involved in cancer progression heralds a new era in therapeutic intervention.

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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis.

AAPS PharmSciTech

June 2024

Department of Pharmaceutics, Faculty of Pharmacy, MS Ramaiah University of Applied Sciences, University House, Gnanagangothri Campus, New BEL Road, MSR Nagar, Bengaluru, 560054, India.

Article Synopsis
  • Biologics, especially lyophilized human placenta (LHP), are gaining attention for their therapeutic potential in osteoarthritis (OA) due to their unique properties like immune-privileged nature and compatibility with the body.
  • The study identified six bioactive constituents in LHP that help regulate cell interaction with the extracellular matrix, confirming the presence of important proteins via various techniques like mass spectrometry and ELISA.
  • LHP demonstrated high bioactivity and low toxicity in skin cell tests, supporting its potential use as a therapeutic agent for cartilage repair in OA.
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Preconception care (PCC) encompasses a set of actions taken before pregnancy to support the health and well-being of women before conception to improve maternal and child health (MCH) outcomes. The utilization of PCC services is influenced by multifaceted factors that can either enable or impede women's capacity to access and utilize them effectively. This scoping review examined the barriers and facilitators influencing the utilization of PCC services among women of reproductive age (15-49 years) at both individual and community levels.

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Molecular dynamic investigation for Roco4 kinase inhibitor as treatment options for parkinsonism.

J Mol Model

April 2024

Department of Food Technology, Faculty of Life and Allied Health Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, 560054, Karnataka, India.

Context: Parkinson's disease is a neurodegenerative condition characterized by the degeneration of dopaminergic neurons, resulting in motor disabilities such as rigidity, bradykinesia, postural instability, and resting tremors. While the exact cause of Parkinson's remains uncertain, both familial and sporadic forms are often associated with the G2019S mutation found in the kinase domain of LRRK2. Roco4 is an analogue of LRRK2 protein in Dictyostelium discoideum which is an established model organism to investigate LRRK2 inhibitors.

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Objective: Tribal population in India (8.6% of the total population) have a greater prevalence of tuberculosis compared to the national average. The article aims to study out-of-pocket expenditure (OOPE), hardship financing, and impoverishment effects of TB hospitalisation treatment among tribal populations in India.

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Introduction: The burden of non-communicable diseases (NCDs) is a major public health concern across the world. Various initiatives have tried to address these with varying degrees of success.

Objective: The objective is to assess and collate existing evidence in implementation research done in India on three broad domains of NCDs namely, cardiovascular diseases (CVD), diabetes mellitus (DM), and mental health (MH) in India.

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Multi-Target Inhibitors are the upcoming frontrunners of the antibiotic world as they provide significant advantage over drug resistance development. Antibacterial drug discovery research, requires more robust and innovative approaches such as multi-target inhibiting drugs, which over comes the innate hurdles in the field of antibiotics. In this current study, a curated set of 5,112 phytochemical molecules were virtually screened for its multi-target inhibition potential against 7 antibacterial protein drug-targets.

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IMPACT OF CULTURAL FACTORS ON THE DENTAL HEALTH STATUS AND BEHAVIOUR OF FEMALES IN THEIR GESTATION PERIOD.

Georgian Med News

November 2023

2Department of Public Health Dentistry, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bangalore, India.

Aim - to evaluate the effect of cultural factors on the oral health status and behaviour of pregnant women in Kerala.A cross-sectional study was conducted among 128 females who were pregnant at 2 private hospitals in Kerala. The study tool was a questionnaire for examining the cultural factors impacting the dental health status and behaviour of females in their gestation period, which was framed based on a review of the literature.

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Background: Globally, among all the vector-borne diseases, mosquito-borne diseases are responsible for a substantial number of cases and deaths and amount to an economic cost of US $12 billion per year. However, there is a dearth of systematic research conducted on the economic burden of mosquito-borne diseases. To address the lack of comprehensive information on this topic, a systematic review will be conducted to synthesize evidence for informing targeted policies and strategies addressing this growing burden and for better financial protection of households.

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Objectives: The state of West Bengal witnessed a significant surge of COVID-19 in all three waves. However, there is a gap in understanding the economic loss associated with COVID-19. This study estimates future non-health gross domestic product (NHGDP) losses associated with COVID-19 deaths in West Bengal, India.

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Multi-target inhibitors are currently trending in the pharmaceutical research, as they possess increased efficacy and reduced toxicity. In this study multi-target inhibitors for breast cancer are explored from a curated list of natural products, i.e.

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Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor characterized by inter and intra-tumor heterogeneity and complex tumor microenvironment. To uncover the molecular targets in this milieu, we systematically identified immune and stromal interactions at the glial cell type level that leverages on RNA-sequencing data of GBM patients from The Cancer Genome Atlas. The perturbed genes between the high vs low immune and stromal scored patients were subjected to weighted gene co-expression network analysis to identify the glial cell type specific networks in immune and stromal infiltrated patients.

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Fusion of Graph and Tabular Deep Learning Models for Predicting Chronic Kidney Disease.

Diagnostics (Basel)

June 2023

Department of Computer Science, Faculty of Computing and Information Technology, King Abdulaziz University, Rabigh 21911, Saudi Arabia.

Chronic Kidney Disease (CKD) represents a considerable global health challenge, emphasizing the need for precise and prompt prediction of disease progression to enable early intervention and enhance patient outcomes. As per this study, we introduce an innovative fusion deep learning model that combines a Graph Neural Network (GNN) and a tabular data model for predicting CKD progression by capitalizing on the strengths of both graph-structured and tabular data representations. The GNN model processes graph-structured data, uncovering intricate relationships between patients and their medical conditions, while the tabular data model adeptly manages patient-specific features within a conventional data format.

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Background & Objectives: Oral squamous cell carcinoma (OSCC) is widely prevalent in the Indian subcontinent mainly due to habit-associated aetiologies. Immune regulation and angiogenesis are the part of tumourigenesis that play a crucial role in metastasis and survival. However, the concurrent expression of vascular endothelial growth factor (VEGF) and CD3 (immune regulator receptor on T-lymphocyte) in the same OSCC tissue samples has not been reported in the Indian population.

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Nanomaterials-based Bioanalytical Sensors for the Detection of Oral Cancer Biomarkers.

J Contemp Dent Pract

February 2023

College of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah, United States of America; Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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Purine antimetabolites associated Pneumocystis jirovecii pneumonia.

Pharmacoepidemiol Drug Saf

November 2023

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Purpose: To detect the possible safety signal of purine antimetabolites associated with Pneumocystis jirovecii pneumonia through disproportionality analysis in the FDA Adverse Event Reporting System (FAERS) Database.

Methods: A case/non-case retrospective disproportionality analysis was performed in the publicly available FAERS database using AERSmine (2004Q1-2021Q3). Four models were developed to explore the signal strength of PAs among different populations with possible confounding factors.

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