Association of baseline subject characteristics with changes in coronary calcification assessed by F-sodium fluoride PET/CT.

Objective: The goal of this study was to test if changes in coronary microcalcification over a two year period assessed by fluorine-18-sodium fluoride (F-NaF) positron emission tomography/computed tomography (PET/CT) are associated with baseline subject characteristics.

Subjects And Methods: This prospective study included healthy female (N=8, age 52±10 years, body mass index(BMI) 24±1.7kg/m) and male (N=15, age 50±10 years, BMI 27±2.

Prospective Study of Systemic Yttrium-90 Elution during Radioembolization of Hepatic Metastases.

Purpose: To evaluate total blood radioactivity (BR) after SIR-Spheres yttrium-90 (Y) radioembolization and differences in BR based on delivery method.

Materials And Methods: Twenty participants with hepatic metastases undergoing first radioembolization were prospectively enrolled from December 2017 to June 2018. Blood samples were drawn at baseline and 0, 10, 20, 60, and 120 minutes after Y administration.

F-sodium fluoride PET/CT provides prognostic clarity compared to calcium and Framingham risk scoring when addressing whole-heart arterial calcification.

Aims: To investigate the benefit of utilizing F-sodium fluoride (NaF) PET/CT over calcium and Framingham scoring for potential preventative coronary artery disease (CAD) intervention.

Methods And Results: This retrospective study included 136 participants (ages 21-75, BMI 18-43 kg/m): 86 healthy controls and 50 patients. CT heart segmentations were superimposed onto PET images and standard uptake values (SUV) were calculated by a semi-auto segmentation method of drawing volumes of interest around the heart.

Iatrogenic celiac and hepatic artery dissections during intra-arterial regional tumor therapies: a 16-year retrospective review.

Purpose: To identify the incidence and outcomes of iatrogenic celiac and hepatic artery dissections during transarterial therapies, including bland embolization, chemoembolization, radioembolization (TARE), and pre-TARE scintigraphic mapping.

Methods: The institution's quality assessment database, electronic medical record, and picture archiving and communication system were reviewed to identify all patients who underwent transarterial locoregional therapy from 1/2001 to 7/2017 and to determine the incidence of iatrogenic dissection, to assess patency of the arteries after dissection, and to assess the ability to complete therapy.

Results: 2253 patients underwent 3776 transarterial hepatic oncology procedures.

Evolving Role of MR Imaging and PET in Assessing Osteoporosis.

An imbalance in bone remodeling results in many metabolic bone diseases, such as osteoporosis. fluorine-18 sodium fluoride PET imaging allows the assessment of bone remodeling process in a anatomy specific manner. On the other hand structural imaging modalities such as MRI can now generate high resolution images of bone including the trabecular and cortical microstructure.

Combined chemoembolization and thermal ablation for the treatment of metastases to the liver.

Purpose: The purpose of the study was to evaluate safety, time to recurrence, and overall survival (OS) in patients with liver metastases (LM), treated with transarterial chemoembolization (TACE) followed by ablation.

Materials And Methods: This retrospective study included all patients with LM treated with combined TACE and ablation from August 1998 to September 2015. Forty-two patients (12 women, 30 men; age 62.

Feasibility of assessing bone matrix and mineral properties in vivo by combined solid-state 1H and 31P MRI.

Purpose: To develop and evaluate an integrated imaging protocol for bone water and phosphorus quantification in vivo by solid-state 1H and 31P MRI.

Materials And Methods: All studies were HIPAA-compliant and were performed with institutional review board approval and written informed consent. Proton (1H) ultra-short echo-time (UTE) and phosphorus (31P) zero echo-time (ZTE) sequences were designed and implemented on a 3 T clinical MR scanner to quantify bone water and mineral in vivo.

Solid-State Quantitative (1)H and (31)P MRI of Cortical Bone in Humans.

Magnetic resonance imaging (MRI) plays a pivotal role for assessment of the musculoskeletal system. It is currently the clinical modality of choice for evaluation of soft tissues including cartilage, ligaments, tendons, muscle, and bone marrow. By comparison, the study of calcified tissue by MRI is still in its infancy.

Cortical bone water concentration: dependence of MR imaging measures on age and pore volume fraction.

Purpose: To quantify bulk bone water to test the hypothesis that bone water concentration (BWC) is negatively correlated with bone mineral density (BMD) and is positively correlated with age, and to propose the suppression ratio (SR) (the ratio of signal amplitude without to that with long-T2 suppression) as a potentially stronger surrogate measure of porosity, which is evaluated ex vivo and in vivo.

Materials And Methods: Human subject studies were conducted in compliance with institutional review board and HIPAA regulations. Healthy men and women (n = 72; age range, 20-80 years) were examined with a hybrid radial ultrashort echo time magnetic resonance (MR) imaging sequence at 3.

Performance of μMRI-Based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength.

Purpose: To assess the performance of a 3D fast spin echo (FSE) pulse sequence utilizing out-of-slab cancellation through phase alternation and micro-magnetic resonance imaging (μMRI)-based virtual bone biopsy processing methods to probe the serial reproducibility and sensitivity of structural and mechanical parameters of the distal tibia at 7.0T.

Materials And Methods: The distal tibia of five healthy subjects was imaged at three timepoints with a 3D FSE sequence at 137 × 137 × 410 μm(3) voxel size.

Spatio-temporal activity in real time (STAR): optimization of regional fMRI feedback.

The use of real-time feedback has expanded fMRI from a brain probe to include potential brain interventions with significant therapeutic promise. However, whereas time-averaged blood oxygenation level-dependent (BOLD) signal measurement is usually sufficient for probing a brain state, the real-time (frame-to-frame) BOLD signal is noisy, compromising feedback accuracy. We have developed a new real-time processing technique (STAR) that combines noise-reduction properties of multi-voxel (e.

Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging.

Purpose: To develop and evaluate a method based on ultrashort echo-time radial magnetic resonance (MR) imaging to quantify bone water (BW) concentration as a new metric of bone quality in human cortical bone in vivo.

Materials And Methods: Human subject studies were institutional review board approved and HIPAA compliant; informed consent was obtained. Cortical BW concentration was determined with custom-designed MR imaging sequences at 3.