Retinal oculomics and risk of incident aortic aneurysm and aortic adverse events: a population-based cohort study.

Background: The asymptomatic onset and extremely high mortality rate of aortic aneurysm (AA) highlight the urgency of early detection and timely intervention. The alteration of retinal vascular features (RVFs) can reflect the systemic vascular properties, and be widely used as the biomarker for cardiovascular disease risk prediction. Therefore, we aimed to investigate associations of RVFs with AA and its progression.

Incidence and treatment of anastomotic leakage after esophagectomy in German acute care hospitals: a retrospective cohort study.

Background: Anastomotic leakage (AL) is a major concern following esophagectomy due to the associated morbidity and mortality. The impact of hospital volume on postoperative outcomes after esophagectomy has previously been reported. The aim of this study was to analyze the current trends in postoperative anastomotic leakage and associated failure-to-rescue after esophagectomy in relation to hospital volume in German acute care hospitals using real-world data from the German Diagnosis-Related Groups (G-DRG) database.

Expression of Plasma Levels of miRNA-181b and miRNA-21 in Patients With Abdominal Aortic Aneurysms and Their Effect on Clinical Outcome After Endovascular Treatment.

Introduction: Abdominal aortic aneurysms (AAA) are major causes of morbidity and mortality in the elderly population. Endovascular aneurysm repair (EVAR) is associated with lower complications rates than conventional treatment; however, rigorous follow-up with contrast imaging is required to confirm aneurysmal sac exclusion. The main objective of this study was to quantify and evaluate miRNA expression response to EVAR based on serum dosages at the 6-month follow-up.

Comparison of the efficacy of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: meta-analysis of randomized controlled trials.

Background: Preoperative neoadjuvant chemoradiotherapy (nCRT) is considered to be the standard treatment strategy for locally advanced rectal cancer (LARC); however, the risk of adverse events and postoperative recurrence remains significant. This study aimed to evaluate the non-inferiority of neoadjuvant chemotherapy (nCT) compared with nCRT in patients with LARC and to assess the possibility of eliminating radiotherapy on the basis of guaranteed efficacy.

Materials And Methods: We searched the PubMed, Embase, and Cochrane Library databases to identify randomized controlled trials (RCTs) comparing the efficacy of nCRT and nCT for LARC.

Incorporating an Elevated Perfusion Index in the Right Hand Enhanced Screening Sensitivity for Critical Aortic Arch Obstruction in Newborn Infants.

Aim: Newborn infants with critical aortic arch obstruction are often undiagnosed at discharge, despite screening. This study investigated if adding the perfusion index improved early detection.

Methods: We retrospectively studied 38 newborn infants with critical aortic arch obstruction, who were routinely screened in 2014-2019 by 13 Swedish hospitals using pulse oximetry and the perfusion index.

Tissue Plasminogen Activator for COVID-19-induced Severe Acute Respiratory Distress Syndrome: A Controlled Clinical Trial.

Objective: This study aimed to assess the safety and efficacy of tissue Plasminogen Activator (tPA) in patients with COVID-19-induced severe Acute Respiratory Distress Syndrome (ARDS).

Methods: The intervention group consisted of eligible patients with severe ARDS due to COVID-19 admitted to the Intensive Care Unit (ICU) of a university hospital. We selected the control group from admitted patients treated in the same ICU within the same period.

The Impact of Mercury from Dental Amalgams on Pregnancy and Childhood: A Health and Risk Assessment Evaluation.

Mercury is a pervasive global pollutant, with primary anthropogenic sources including mining, industrial processes, and mercury-containing products such as dental amalgams. These sources release mercury into the environment, where it accumulates in ecosystems and enters the food chain, notably through bioamplification in marine life, posing a risk to human health. Dental amalgams, widely used for over a century, serve as a significant endogenous source of inorganic mercury.

The Association of Geriatric Nutritional Risk Index and Chronic Kidney Disease Stages on Survival and Cardiovascular or Limb Events Following Endovascular Therapy.

Background: There are little available data about the impact of geriatric nutritional risk index (GNRI) on clinical outcomes following endovascular therapy (EVT) in chronic limb-threatening ischemia (CLTI) regarding the severities of renal dysfunction (RD).

Aims: The aim of this study is to evaluate the impact of GNRI on clinical outcomes following EVT in CLTI regarding the severities of RD.

Methods: We enrolled 705 consecutive CLTI cases treated with EVT between January 2010 and December 2019 at our hospital.

Elderly Patients With Aplastic Anemia: Treatment Patterns and Outcomes in the Real World.

We retrospectively analyzed a large international cohort of 1113 patients with aplastic anemia to evaluate treatment choice and outcome in elderly patients as compared with a younger population. Overall, 319 (29%) patients were > 60 years old at diagnosis (60-64 years (n = 85), 106 65-69 years (n = 106), and 128 > 70 years (n = 128)). Elderly patients showed a more severe thrombocytopenia at onset and a significantly lower overall response (complete plus partial) to first-line therapy at 6 months as compared to younger patients (47% vs.

Sex-dependent modulation of caerulein-induced acute pancreatitis in C57BL/6J mice.

Acute pancreatitis (AP) is a life-threatening condition, with a higher mortality rate in men than women and in which estrogens might play a protective role. This study aimed to investigate sex-dependent differences in a mouse model of caerulein-induced AP. Thirty-six C57BL/6J mice (19 females and 17 males) were treated intraperitoneally with phosphate-buffered saline or caerulein, and sacrificed 12 hours, 2 days, or 7 days after the last injection.

Samarium as a Catalytic Electron-Transfer Mediator in Electrocatalytic Nitrogen Reduction to Ammonia.

Samarium diiodide (SmI) exhibits high selectivity for NR catalyzed by molybdenum complexes; however, it has so far been employed only as a stoichiometric reagent (0.3 equiv of NH per Sm) combined with coordinating proton sources (e.g.

Enhanced anti-inflammatory and anti-fibrotic effects of nanoparticles loaded with a combination of - extracts.

Metabolic associated steatohepatitis characterized by lipid accumulation, inflammation and fibrosis, is a growing global health issue, contributing to severe liver-related mortality. With limited effective treatments available, there is an urgent need for novel therapeutic strategies. , rich in antioxidants, offers potential for combating steatohepatitis, but its cytotoxicity presents challenges.

Loneliness among Adults Aging with Intellectual and Developmental Disabilities: The Importance of Living Situation.

Background And Objectives: Loneliness is a serious public health concern among the aging population. Not only is loneliness an unpleasant emotional experience, it is also associated with worse health, well-being, and even mortality. This is a particularly important issue among the population aging with intellectual and developmental disabilities, who are more likely to experience loneliness across the life course, and who - particularly if living in an intermediate care facility (ICF) or nursing facility - may lack social connections.

An isolated extra-articular procedure can be indicated for patients with minor instabilities and intact graft after anterior cruciate ligament reconstruction.

Background: Some patients submitted to isolated ACL reconstruction may have symptomatic postoperative rotational instability. The objective of this study was to evaluate a population with mild rotatory instability after ACL reconstruction, which was submitted to an isolated extra-articular procedure.

Methods: Patients submitted to an isolated extra-articular procedure after ACL reconstruction were retrospectively evaluated.

Anxiety, depression, and their association with unintentional injury risk among older adult populations in Guangxi, China: a cross-sectional study.

Background: The aging population presents a significant public health challenge, particularly concerning mental health and injury prevention. Anxiety and depression are common among the older adult, affecting their quality of life and increasing the risk of unintentional injuries (UI). This study aims to explore the association between anxiety and depression and UI risk among the older adult in Guangxi, China, using data from the 2023 National Health Service Survey.

Proposal for a revised Barthel index classification based on mortality risk assessment in functional dependence for basic activities of daily living.

Introduction: Functional dependence on the performance of basic activities of daily living (ADLs) is associated with increased mortality. In this study, the Barthel index and its activities discriminate long-term mortality risk, and whether changes in this index are necessary to adapt it to detect mortality risk is examined.

Methods: Longitudinal study, carried out at the Orcasitas Health Center, Madrid (Spain), on the functional dependent population (Barthel ≤ 60).

The usefulness of Charlson Comorbidity Index (CCI) scoring in predicting all-cause mortality in Outpatients with Clinical Diagnoses of COPD.

Background: Since comorbid conditions are frequently present in chronic obstructive pulmonary disease (COPD) and affect outcome, a composite scoring system to quantify comorbidity might be helpful in assessing mortality risk.

Methods: We tested the hypothesis that the Charlson Comorbidity Index (CCI) score at the time of an outpatient medical clinic encounter for COPD predicts all-cause mortality. Cox Proportional Hazards analyses were used in 200 randomly selected patients to relate CCI scores to all-cause mortality out to 5 years.

A new pod bioassay method to determine the toxicity of insecticides against Tea mosquito bug, .

The insecticide susceptibility of Waterhouse (Hemiptera: Miridae) is being evaluated using shoot and glass-vial assay as described by IRAC. However, the reliability of the assay depends on feeding preference and contact toxicity. Hence, the cocoa pod was used as a substrate to test the susceptibility of in comparison with existing methods.

A Nonrandomized Pilot Study to Investigate the Acceptability and Feasibility of LivR Well: A Multifaceted 28-Day Home-Based Liver Optimization Program for Acute-on-Chronic Liver Failure.

Background And Aims: Acute-on-chronic liver failure (ACLF) has a 22%-74% 28-day mortality rate and 30%-40% 30-day readmission rate. We investigated the acceptability and feasibility of a multimodal community intervention for ACLF.

Methods: A single-arm nonrandomized pilot study of consecutive participants with ACLF was conducted in a tertiary health service.

Diabetic ketoacidosis treatment outcomes and its associated factors among adult patients with diabetes mellitus admitted to public hospitals in Nekemte Town, Ethiopia: a cross-sectional study.

Background: Diabetic ketoacidosis (DKA) is a serious and acute complication of diabetes mellitus. In Ethiopia, the mortality associated with acute diabetes complications ranges from 9.8% to 12%.

Subclavian Artery Aneurysm Rupture: A Case Report.

Subclavian artery aneurysm is an extremely rare condition with potentially life-threatening complications, including rupture and embolization. This condition is generally the result of atherosclerosis, medial degeneration, trauma, or infection. We report the case of an 83-year-old man who developed hemoptysis due to the rupture of a saccular aneurysm at the origin of the left subclavian artery.

Otitis Media and Its Intracranial Complications: A Delicate Scenario.

Intracranial complications of otitis media are rare but pose a significant risk of morbidity and mortality. We report a case of a 27-year-old man with cognitive impairment who presented with fever, right-sided otalgia, otorrhea, and vomiting for three days. His neurological examination was unremarkable, and a brain computed tomography (CT) revealed right-sided otomastoiditis without intraparenchymal lesions.

Patterns and Outcomes of Acute Poisoning Among Children Presenting to Emergency Department in AlAhsa, Saudi Arabia.

Introduction Acute poisoning in children is still a global health concern that necessitates visiting the emergency department that might associated with morbidity and mortality. It has an impact on social, economic, and health issues, particularly for children under five who account for the majority of poisonings worldwide. Poisoning can result in mild cases, serious complications, or even death; oral ingestion is the most common way that poisoning occurs in children.