Effects of dietary amylose/amylopectin ratio on antioxidant ability and amino metabolism in the liver of weaned piglets undergoing feed transition and challenged with lipopolysaccharide.

To find out whether dietary amylose/ amylopectin ratio (DAR) could attenuate injury in lipopolysaccharide (LPS)-challenged piglets, sixty male weaned piglets (Duroc × Landrace × Yorkshire, 21 days old, 6.51 ± 0.64 kg) were allotted to 5 dietary treatments with 12 cages per treatment, and fed ad libitum with diets different in DAR (0.

Change in mineral composition and cooking quality in legumes grown on semi-arid alfisols due to elevated CO and temperature.

This study aimed to determine the effects of elevated carbon dioxide (eCO) and temperature (eT) on the phytochemical and nutritional parameters of legumes. Field experiments were conducted using black gram ( L.), green gram ( L.

Pb-free metal oxide-based epoxy resin nanocomposites for radiation protection: Physical evaluation analysis approach.

Exposure to mid-energy radiation poses significant health risks, necessitating the development of effective shielding materials. Traditional lead-based shields, while effective, have significant drawbacks including toxicity and environmental concerns. This study investigates the potential of lead-free epoxy resin nanocomposites, incorporating bismuth oxide, nickel oxide, and cerium oxide, for mid-energy radiation protection.

Variation in compressive mechanical properties between subacute and chronic venous thrombosis in a novel unilateral iliac thrombosis model.

Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability to penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding of chronic DVT mechanical properties and a reliable model for testing. Female farm swine underwent a novel, endovenous generation of long-segment unilateral iliac vein thrombosis.

Palovarotene in fibrodysplasia ossificans progressiva: review and perspective.

Introduction: Palovarotene is a retinoic acid receptor gamma agonist that was studied in phase-2 and phase-3 clinical trials for the inhibition of new heterotopic ossification (HO) in fibrodysplasia ossificans progressiva (FOP). Despite numerous setbacks and regulatory delays, palovarotene is now the first approved FOP treatment in the U.S.

When death is desired: A case of MAiD & the CL psychiatrist.

Objectives: Since physician-assisted dying (PAD) has become a part of the clinical dialogue in the United States (US) and other Western countries, it has spawned controversy in the moral, ethical, and legal realm, with significant cross-country variation. The phenomenon of PAD includes 2 practices: Euthanasia and medical aid in dying (MAiD). Although euthanasia has been allowed in different parts of the world, in the US it is illegal.

Gender and Race Differences in Rates of PTSD Service Connection: Results From a Nationally Representative Panel of OEF/OIF/OND Veterans.

Background: Department of Veterans Affairs disability benefits for post-traumatic stress disorder (PTSD), also known as "service connection," have been shown to reduce homelessness and poverty, increase mental health engagement, and improve clinical outcomes. However, gender and race disparities in PTSD service connection have been described in Vietnam and post-Vietnam era Veterans.

Methods: Post-traumatic stress disorder service connection outcomes were assessed in a nationally representative, randomly selected, gender-stratified, prospective panel of 960 Veterans who served during Operations Enduring Freedom, Iraqi Freedom, and New Dawn.

Unveiling Doping Kinetics in Cu(I) Metal Halides for Customized Luminescent Performance.

Intentional doping plays a pivotal role in customizing metal halides' electronic and optical features. This work manipulates the incorporation and distribution of Mn in Cu(I) halide by controlling the elemental steps involved in the growth-doping kinetics as well as investigates the localized lattice and electronic structures in different doping configurations. Complementary experimental and theoretical results demonstrate that a uniform and relatively high Mn doping level can be achieved by a step-tailored strategy that encompasses reducing the growth rate of the halide matrix, enhancing the surface adsorption of Mn, and facilitating the incorporation of the dopants.

Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies.

Background: The human gut microbiome strongly influences host metabolism by fermenting dietary components into metabolites that signal to the host. Our previous work has shown that Intestinimonas butyriciproducens is a prevalent commensal bacterium with the unique ability to convert dietary fructoselysine to butyrate, a well-known signaling molecule with proven health benefits. Dietary fructoselysine is an abundant Amadori product formed in foods during thermal treatment and is part of foods rich in dietary advanced glycation end products which have been associated with cardiometabolic disease.

Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation.

The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. Early innovations, such as cardiac pacemakers and deep brain stimulation, paved the way for these sophisticated technologies. This review traces the historical and technological progression of bioelectronic medicine, culminating in the emerging potential of closed-loop devices for multiple disorders of the brain and body.

Genetic context modulates aging and degeneration in the murine retina.

Background: Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration may shed light onto similar processes in the brain. Genetic makeup strongly influences susceptibility to age-related retinal disease.

Population genomics of premature termination codons in cavefish with substantial trait loss.

Loss-of-function alleles are a pertinent source of genetic variation with the potential to contribute to adaptation. Cave-adapted organisms exhibit striking loss of ancestral traits such as eyes and pigment, suggesting that loss-of-function alleles may play an outsized role in these systems. Here, we leverage 141 whole genome sequences to evaluate the evolutionary history and adaptive potential of single nucleotide premature termination codons (PTCs) in Mexican tetra.

Development and Implementation of Automated Referral Triaging System for Spinal Cord Stimulation Procedure in Pain Medicine.

Effective referral triaging enhances patient service outcomes, experience and access to care especially for specialized procedures. This study presents the development and implementation of an automated triaging system to predict patients who would benefit from Spinal Cord Stimulation (SCS) procedure for their pain management. The proposed triage system aims to improve the triage process by reducing unnecessary appointments before SCS assessment, ensuring appropriate pain management care.

Lemon Juice and Ascorbic Acid Effect on the Metals Extraction from Chamomile, Human Risk Assessment.

The total content of heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn) in chamomile sample, metals content in water chamomile infusions and water infusions with additions of ascorbic acid and lemon juice at different temperatures (70, 80, and 100 °C) and steeping times (3, 5, and 7 min), were determined. The content of heavy metals was determined by flame atomic absorption spectrometry (FAAS). Mean total concentrations of Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn were 0.

Source apportionment, ecological and health risks of potentially toxic elements in street dusts across different land uses in city of Kermanshah, Iran.

In this study, the contamination, ecological and human health risks as well as source apportionment of As, Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn, and V in street dusts of different land-uses in Kermanshah, Iran were investigated. A total of 192 dust samples were taken from 16 sites and were analyzed for their elemental contents using ICP-OES. The computed mean values for the geo-accumulation index (I-geo) and the pollution index (PI) ranged from - 6.

Development and validation of biopsy free nomograms for predicting clinically significant prostate cancer in men with PI-RADS 4 and 5 lesions.

To develop and validate biopsy-free nomograms to more accurately predict clinically significant prostate cancer (csPCa) in biopsy-naïve men with prostate imaging reporting and data system (PI-RADS) ≥ 4 lesions. A cohort of 931 patients with PI-RADS ≥ 4 lesions, undergoing prostate biopsies or radical prostatectomy from January 2020 to August 2023, was analyzed. Various clinical variables, including age, prostate-specific antigen (PSA) levels, prostate volume (PV), PSA density (PSAD), prostate health index (PHI), and maximum standardized uptake values (SUVmax) from PSMA PET-CT imaging, were assessed for predicting csPCa.

Trust in scientists and their role in society across 68 countries.

Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public trust in scientists.

Bose-Einstein condensation of a two-magnon bound state in a spin-1 triangular lattice.

In ordered magnets, the elementary excitations are spin waves (magnons), which obey Bose-Einstein statistics. Similarly to Cooper pairs in superconductors, magnons can be paired into bound states under attractive interactions. The Zeeman coupling to a magnetic field is able to tune the particle density through a quantum critical point, beyond which a 'hidden order' is predicted to exist.

An update on active and passive surveillance for African swine fever in the Dominican Republic.

African swine fever (ASF) is a viral, hemorrhagic disease of swine that is reportable to the World Organisation for Animal Health. Since 2007, ASF has been expanding globally and causing severe disruption to the global swine industry. In 2021, ASF was detected in the Dominican Republic, prompting an emergency response from local and international officials.

Hominin presence in Eurasia by at least 1.95 million years ago.

The timing of the initial dispersal of hominins into Eurasia is unclear. Current evidence indicates hominins were present at Dmanisi, Georgia by 1.8 million years ago (Ma), but other ephemeral traces of hominins across Eurasia predate Dmanisi.

CPT® Codes for MRI Safety - A User's Guide.

The magnetic fields of the MR environment present unique safety challenges. Medical implants and retained foreign bodies can prevent patients from undergoing MR imaging due to interactions between the magnetic fields of the MR environment and the implant or foreign body. These hazards can be addressed through careful MR safety screening and MR examination customization, often allowing these patients with implants to undergo management-altering MR imaging.

Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus.

Objective: To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus erythematosus (SLE).

Methods: Patients enrolled in the Asia Pacific Lupus Collaboration cohort with ≥3 years of prospectively captured data were studied. Flares were assessed at routine visits, while damage ((Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index) was assessed annually.

Enhancing the interactions of ion-tagged oligonucleotides and magnetic ionic liquid supports for the sequence-specific extraction of hepatitis B virus DNA.

Background: Infections from the hepatitis B virus (HBV) are a major risk factor for hepatocellular carcinoma, one of the most common types of liver cancer. Circulating cell-free DNA (ccfDNA) in human plasma can be used as a non-invasive biomarker for diagnosing HBV-related liver diseases. The isolation of target ccfDNA sequences is often challenging due to the co-extraction of highly abundant non-target DNA from samples.

Manganese Dioxide-based In Situ Vaccine Boosts Antitumor Immunity via Simultaneous Activation of Immunogenic Cell Death and the STING Pathway.

In situ vaccine (ISV) can activate the anti-tumor immune system by inducing immunogenic cell death (ICD) at the tumor site. However, the development of tumor ISV still faces challenges due to insufficient tumor antigens released by tumor cells and the existence of tumor immunosuppressive microenvironment (TIME). Targeting the STING pathway has been reported to enhance the adjuvant effects of in situ tumor vaccines by initiating innate immunity.

Total Knee Arthroplasty Automated Implant Detector: An Uncertainty-Aware Deep Learning Classifier to Identify Total Knee Arthroplasty Implants.

Background: A drastic increase in the volume of primary total knee arthroplasties (TKAs) performed nationwide will inevitably lead to higher volumes of revision TKAs in which the primary knee implant must be removed. An important step in preoperative planning for revision TKA is implant identification, which is time-consuming and difficult even for experienced surgeons. We sought to develop a deep learning algorithm to automatically identify the most common models of primary TKA implants.