The Herpes Zoster Patient Pathway and Gaps in Current Vaccination Guidelines in Southeast Asia: Summary of a Zoster Experts' Network Scientific Workshop.

The burden of herpes zoster (HZ) is recognized worldwide; however, there is seemingly limited information on incidence and vaccination practices in Southeast Asia (SEA). A scientific workshop was held by the Zoster Experts' Network to exchange and consolidate insights on the burden of HZ and the patient pathway in SEA. The workshop included practicing clinical experts and public health specialists/epidemiologists from Indonesia, Malaysia, the Philippines, Thailand, and Vietnam.

The Strategic Advisory Group of Experts (SAGE) on Immunization-Past, Present and Future.

Background/objectives: In November 1999, WHO established the Strategic Advisory Group of Experts (SAGE) on Immunization as a multidisciplinary group of experts to provide high-level recommendations on vaccines and immunization.

Methods: This review provides an overview of SAGE's work in the past 25 years. It further outlines the processes and methods currently used by SAGE and highlights some of its major achievements.

Development and Evaluation of a Candidate Inactivated Vaccine Against Bluetongue Virus Serotype 4 (BTV4).

Objectives: Although bluetongue is not a contagious disease, it is easily transmitted and spread by appropriate insect vectors, causing great economic damage. Climate change has led to the fact that vectors and diseases have spread to the top of Northern Europe, causing great economic losses in livestock production. An even greater problem is controlling the disease, because numerous species of domestic and wild ruminants are susceptible to bluetongue.

Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD).

: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. However, it has poor oral bioavailability. We investigated the effect of a novel lipid formulation on its absorption in humans and on its tissue distribution in mice.

Nitrogen-Fixing and : Two Novel Species from Plant Rhizospheres.

Two strains, M1 and H32 with nitrogen-fixing ability, were isolated from the rhizospheres of different plants. Genome sequence analysis showed that a (trogen ixation) gene cluster composed of nine genes () was conserved in the two strains. Phylogenetic analysis based on the 16S rRNA gene sequence showed that strains M1 and H32 are members of the genus .

Characterization of Unusual Serogroups of .

Most cases of invasive meningococcal disease (IMD) in Europe are caused by isolates of the serogroups B, C, W, and Y. We aimed to explore cases caused by other unusual serogroups. We retrospectively screened IMD cases in the databases of the National Reference Center for Meningococci and in France between 2014 and 2023.

Application of a Gyroid Structure for Thermal Insulation in Building Construction.

This paper concerns research into the use of 3D-printed gyroid structures as a modern thermal insulation material in construction. The study focuses on the analysis of open-cell gyroid structures and their effectiveness in insulating external building envelopes. Gyroid composite samples produced using DLP 3D-printing technology were tested to determine key parameters such as thermal conductivity (λ), thermal resistance (R) and heat transfer coefficient (U) according to ISO 9869-1:2014.

Influence of Structural Optimization on the Physical Properties of an Innovative FDM 3D Printed Thermal Barrier.

This article describes an innovative thermal insulation barrier in the form of a sandwich panel manufactured using 3D FDM printing technology. The internal structure (core structure) of the barrier is based on the Kelvin foam model. This paper presents the influence of the parameters (the height h and the porosity P of a single core cell) of the barrier on its properties (thermal conductivity, thermal resistance, compressive strength, and quasi-static indentation strength).

Application of a Generalized Utility Function to Determine the Optimal Composition of Geopolymer Mortar.

The aim of the presented research was to evaluate the impacts of modifications to the technical properties of fly ash-based geopolymer composites, particularly focusing on enhancing the thermal insulation. Through the utilization of a generalized utility function, optimal dosages of additives such as perlite sand, waste perlite powder, and cenospheres were determined. The study aimed to increase the thermal insulation of the composites while maintaining satisfactory compressive and flexural strength.

Effect of Chemical Structure and Apparent Density of Rigid Polyurethane Foams on the Properties of Their Chemical Recycling Products.

The aim of this work was to synthesize polyurethane foams based on petrochemical polyols and biopolyols with specific apparent densities (40, 60, 80, 100, and 120 kg/m), test their properties, glycolyze them, and finally analyze each glycolyzed product. The petroleum-based foams, used as reference foams, and the bio-based foams underwent a series of standard tests to define their properties (the content of closed cells 20-95%, compressive strength 73-1323 kPa, thermal conductivity 24-42 mW/m∙K, brittleness 4.6-82.

Fungal Strain Influences Thermal Conductivity, Hydrophobicity, Color Homogeneity, and Mold Contamination of Mycelial Composites.

Mycomaterials are biomaterials made by inoculating a lignocellulosic substrate with a fungus, where the mycelium acts as a binder and enhances material properties. These materials are well suited as sustainable alternatives to conventional insulation materials thanks to their good insulation properties, low density, degradability, and fire resistance. However, they suffer from mold contamination in moist environments and poor perception ("organic" appearance).

An Investigation on the Spark Plasma Sintering Diffusion Bonding of Diamond/Cu Composites with a Cr Interlayer.

Spark plasma sintering (SPS) is an effective technique for studying the diffusion bonding of diamond/Cu composites, and has the potential to advance the application of copper matrix composites. This study investigates the SPS diffusion bonding of diamond/Cu composites using a chromium (Cr) interlayer. The effects of process parameters on the microstructure and mechanical properties of the bonding interface were evaluated through shear strength testing and SEM analysis.

Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.

Yakutia is one of the coldest permanently inhabited regions in the world, characterized by a subarctic climate with average January temperatures near -40 °C and the minimum below -60 °C. Recently, we demonstrated accelerated epigenetic aging of the Yakutian population in comparison to their Central Russian counterparts, residing in a considerably milder climate. In this paper, we analyzed these cohorts from the inflammaging perspective and addressed two hypotheses: a mismatch in the immunological profiles and accelerated inflammatory aging in Yakuts.

Darolutamide in Combination with Radium-223 Exhibits Synergistic Antitumor Efficacy in LNCaP Prostate Cancer Models.

Despite treatment, prostate cancer commonly progresses into castration-resistant prostate cancer (CRPC), which remains largely incurable, requiring the development of new interventions. Darolutamide is an orally administered second-generation androgen receptor inhibitor indicated for patients with non-metastatic CRPC or metastatic hormone-sensitive prostate cancer. Here, we evaluated the effect of androgen receptor (AR) inhibition by darolutamide in combination with DNA double-strand-break-inducing targeted radium-223 alpha therapy in vitro and in an intratibial LNCaP xenograft model mimicking prostate cancer metastasized to bone.

Thyroid Function and Morphology in Gaucher Disease: Exploring the Endocrine Implications.

Gaucher disease (GD), the most common ultra-rare metabolic disorder, results from lipid accumulation. Systemic inflammation, cellular stress, and metabolic dysfunction may influence endocrine function, including the thyroid. This study evaluated thyroid function and morphology in 60 GD patients, alongside carbohydrate and lipid metabolism.

One-Year Outcomes of Trabeculotomy with 120°, 180°, or 360° Schlemm's Canal Incision for Primary Open-Angle Glaucoma: A Retrospective Study.

Primary open-angle glaucoma (POAG), if caused by elevated intraocular pressure (IOP), may require a trabeculotomy (LOT), in which the trabecular meshwork (TM) and Schlemm's canal (ISC) are incised. However, the association between the incision angle and outcomes remains unclear. Therefore, in this study, we investigated the surgical outcomes of a trabeculotomy combined with cataract surgery in patients with POAG over a 12-month follow-up period.

Nutrition-Focused Quality Improvement Programs in Pediatric Care.

Nutrition is fundamental to a child's growth and development. However, nutritional health is often compromised by acute and chronic conditions and treatments that can commonly result in malnutrition. Malnutrition encompasses undernutrition and overnutrition and may be exacerbated by food insecurity.

A Rapid Systematic Review Assessing the Effectiveness of Interventions to Promote Self-Management in Workers with Long-Term Health Conditions and Disabilities.

The objective of this study was to synthesise evidence assessing the effectiveness of workplace-based interventions that promote self-management of multiple long-term conditions or disabilities, e.g., type I and II diabetes, asthma, musculoskeletal injury/disorder, cancer, and mental ill-health.

Identification and Bioactivity Analysis of a Novel Species, sp. nov. Bos-x6-28, Isolated from Feces of the Yak ().

The identification of novel bacterial species from the intestines of yaks residing on the Qinghai-Tibet Plateau is pivotal in advancing our understanding of host-microbiome interactions and represents a promising avenue for microbial drug discovery. In this study, we conducted a polyphasic taxonomic analysis and bioactive assays on a strain, designated Bos-x6-28, isolated from yak feces. The findings revealed that strain Bos-x6-28 shares a high 16S rRNA gene sequence similarity (98.

5-HT Receptors in the BNST Modulate Contextual Fear Conditioning Without Affecting Acute Early Life Stress-Enhanced Fear Learning in Adult Rats.

Background/objectives: Rodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological and behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with post-traumatic stress disorder (PTSD) present with a spectrum of debilitating anxiety symptoms that result from exposure to one or more traumatic events, with individuals exposed to early adverse experiences and women having increased vulnerability for diagnoses; however, the mechanisms of this increased vulnerability remain unknown.

A Randomized Controlled Trial to Test the Effects of Repetitive Peripheral Magnetic Stimulation Versus Neuromuscular Electrical Stimulation in Patients with Spastic Hemiparesis After Stroke (REPMAST): Study Protocol.

Background/objectives: Innovative therapies are needed to reduce disability, facilitate activities of daily living, and improve the quality of life in patients with stroke. Non-invasive methods of stimulating the peripheral and central nervous system are increasingly being used to enhance the effects of existing therapies in stroke rehabilitation. One potentially relevant method for achieving greater improvement is repetitive peripheral magnetic stimulation (rPMS).

Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice.

Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were previously clarified in model mice [Ednrb(+/-);RET-mice]. External treatment with luteolin, but not that with hesperetin or diosmetin, alleviated hair graying in Ednrb(+/-);RET-mice.

Differential effects of gestational Cannabis smoke and phytocannabinoid injections on male and female rat offspring behavior.

Our understanding of the implications of gestational Cannabis exposure (GCE) remains unclear as Cannabis use increases worldwide. Much of the existing knowledge of the effects of GCE has been gained from preclinical experiments using injections of isolated Δ-tetrahydrocannabinol (THC) at relatively high doses. Few investigations of the effects of GCE to smoke from the whole Cannabis flower have been conducted, despite this being the most common mode of human consumption.

Atractylenolide Ⅲ partially alleviates tunicamycin-induced damage in porcine oocytes during in vitro maturation by reducing oxidative stress.

Assisted reproductive technology (ART) is widely used to address infertility and enhance reproductive outcomes in livestock. Among various ART techniques, in vitro maturation (IVM) is commonly used to obtain high-quality oocytes but is susceptible to oxidative stress. In traditional Chinese medicine, Rhizoma Atractylodis Macrocephalae (Bai Zhu) is used to enhance maternal and fetal health.